Vaccinate already still die. vaccinate for what?
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[COVID-19 Virus] The Sinkies are fucked Thread.
- Thread starter zhihau
- Start date
Covid-19 antibody cocktail treatment to arrive in Singapore in October: NCID
September 30, 2021published at 12:39 PMByClara ChongThe Straits Times
The latest addition to this arsenal of treatment options is a Covid-19 antibody cocktail, which was developed by Regeneron and Roche. It is expected to arrive here next month, the National Centre for Infectious Diseases (NCID) said on Tuesday evening (Sept 28) in response to queries from The Straits Times.
This monoclonal antibody treatment can be used to treat patients who are mildly sick but at risk of severe illness, Dr Shawn Vasoo, clinical director of NCID, said.
It was granted interim authorisation to be used for the treatment of patients with mild to moderate Covid-19 under the Pandemic Special Access Route (PSAR) by Singapore's Health Sciences Authority (HSA) on Sept 21.
HSA said on its website that infectious diseases specialists will be able to use this therapy for those aged 18 and older, who do not require oxygen supplementation and are at risk for progression to severe Covid-19.
An ongoing phase three study that HSA reviewed has found that this antibody treatment cut the relative risk of Covid-19 disease progression to requiring acute treatment in hospital or death by 70 per cent, compared to the placebo group.
Symptoms also cleared up an average of four days earlier compared to the placebo group.
On Sept 24, a World Health Organisation panel also recommended the use of this antibody cocktail for patients at high risk of hospitalisation and those severely ill who had no natural antibodies.
The treatment was granted US emergency use authorisation in November last year, having gained attention when used to treat former President Donald Trump's Covid-19 illness last year. Europe is reviewing the therapy, while Britain approved it last month.
Apart from this antibody cocktail treatment, there are four other drugs in use to treat Covid-19 here.
Antibody drug sotrovimab
As at Sept 22, 64 NCID patients here have been on sotrovimab. The drug was made available to healthcare institutions from this month.Sotrovimab is a single-dose monoclonal antibody drug administered through intravenous infusion.
Monoclonal antibodies are laboratory-made proteins that act like antibodies in helping the body to fight off infection.
It can be used to treat patients who do not require oxygen supplementation and have mild to moderate Covid-19 disease but are at risk of progressing to more serious illness.
The drug, developed by GlaxoSmithKline Pte Ltd (GSK) and Vir Biotechnology, was granted interim authorisation under the PSAR route by HSA on June 30.
Arthritis drug tocilizumab and steroid dexamethasone
As at Sept 22, 60 NCID patients have been on tocilizumab and another 289 on dexamethasone.Manufactured by Swiss drugmaker Roche, tocilizumab is an intravenous anti-inflammatory monoclonal antibody used to treat rheumatoid arthritis.
It has been reported to reduce the risk of death in hospitalised patients with severe Covid-19, especially when combined with the steroid dexamethasone, a cheap and widely used steroid used to reduce inflammation in other diseases.
These drugs are given to patients in intensive care with hyper-inflammation and have been shown to decrease mortality, Dr Vasoo said.
Researchers in the United Kingdom have also found that the drug also shortened patients' length of stay at hospitals and reduced the need for a ventilator.
The study was part of the Recovery trial, an international clinical trial that has been testing a range of potential treatments for Covid-19 since March last year.
Antiviral drug remdesivir
As at Sept 22, 580 NCID patients have been treated with remdesivir.Administered in the early stage of Covid-19 illness, it hastens time to recovery.
Singapore researchers find drug cocktail effective against Covid-19 Delta variant
Remdesivir, developed by US drugmaker Gilead Sciences, received conditional approval by Singapore's Health Sciences Authority to be used outside of clinical trials in June last year.
There are also some repurposed drugs that have not proven useful for Covid-19 treatment.
While some of these drugs may have demonstrated activity against the virus in a lab setting, their results in real-life clinical studies still remain to be seen, Dr Vasoo said.
The definitive way to assess a drug's efficacy is via a double-blind randomised controlled trial in which at least two groups of patients get the drug or placebo or receive standard care, and neither the investigators nor the patients are aware of what treatment was given.
Some of these drugs include:
Ivermectin, a medication used to treat parasitic infections
While many have called for ivermectin to be used as part of an outpatient treatment plan for Covid-19, data regarding it has been fraught with inconsistencies, Dr Vasoo said.At least two double-blind randomised controlled trials purporting its use showed serious flaws, with one being retracted for possible plagiarism and data flaws and the other exhibiting problems in its methodology and results, Dr Vasoo explained.
ALSO READ: Stop horsing around: If you're planning on taking horse dewormer ivermectin or volcanic ash to treat Covid-19, don't do it
Other more robust randomised controlled trials have not shown ivermectin to have any effect in preventing hospitalisation or an earlier resolution of symptoms, he said.
"Ivermectin cannot be recommended at this point as part of the standard therapy of Covid-19, outside of well-designed clinical trials," Dr Vasoo said.
Anti-malaria drug hydroxychloroquine and antiretroviral drugs
Hydroxychloroquine and antiretroviral drugs commonly used to treat the human immunodeficiency virus (HIV) - such as lopinavir-ritonavir - have not shown efficacy in randomised controlled trials to date, Dr Vasoo said."The major definitive trials which have informed practice have been completed. It is unlikely that any further new, ground-breaking trials will be attempted," he said.
Gout medication probenecid
Probenecid, a medication that is primarily used to treat gout and has broad antiviral properties, was studied in the laboratory and showed activity in blocking Sars-CoV-2 replication.However, there is no current robust human trial data yet, Dr Vasoo said.
At present, Singapore is not looking into this drug in relation to Covid-19 treatment.
I heard our scholar politicians take clue from UK
UK has a population 10x of Singapore and they have opened up.
Everyday UK 30000+ cases (this is in line with Lawrence and OYK's guidance for 3000-5000 cases, proportionally for Singapore).
Then UK has 150 deaths daily, so proportionally 10-20 dead in Singapore daily is acceptable for our scholar policymakers.
Our additional risks:
1. Our seniors have higher risks because their grandkids and kids more likely see them daily, weekly, monthly than the British.
2. AZ offers better protection than Pfizer after 3 months, so in the long-run, our hospitals will cannot cope.
I think schools can close all the way till year end.
How to reopen in mid-Oct with 2000-5000 daily cases?
How to reopen in mid-Oct with 2000-5000 daily cases?
Oppies don't like it when I point out hard truths to them. The hard truth is that PAP will continue to rule Singapore with 100% control of the government for the next few GEs.
We've been making contingency plans since SARS. Our government has situation rooms for wargaming all sorts of possible scenarios ranging from war to pandemics. PAP has everything covered. 500 people requiring oxygen is a derisory number. We can easily supply oxygen to 2000 people in the ICUs if needed.
S'pore seniors aged 60 & above strongly urged to stay home next 4 weeks as Covid-19 cases surges - Mothership.SG
mothership.sg
Scroll to continue with content
This extends to those living with seniors above the age of 60, according to the Agency for Integrated Care (AIC).
More than a quarter of the local Covid-19 cases in the past two weeks were aged 60 and above, and from May 2021, there were 257 unvaccinated seniors who were severely affected by Covid-19, and were either in the intensive care unit (ICU), needed oxygen supplementation, or died.
In the next four weeks, seniors are encouraged to minimise group activities and social gatherings, and to minimise mask-off activities, such as eating at hawker centres, and opt for take-away food instead.
AIC also advised seniors to wear a surgical-grade mask properly at all times, and to maintain good hygiene practices, such as frequent hand washing.
Those who haven't been vaccinated should do so as soon as possible, said AIC, pointing out that the risk of an unvaccinated person getting severely ill is almost seven times higher, compared to a vaccinated person.
To minimise their exposure to other infections, seniors are also encouraged to visit hospitals only when necessary.
"If infected with Covid-19, with mild or no symptoms, they need not rush to hospital but can self-isolate at home for their own well-being," said AIC.
"This will position them well for transition to endemic Covid-19," said AIC.
The Covid-19 booster programme for seniors has begun since earlier this month.
AIC's outreach arm, the Silver Generation Office (SGO), has reached out to 670,000 seniors to share information about Covid-19 vaccination, and explain its benefits.
SSO will also make arrangements to escort seniors with mobility issues to vaccination centres.
For homebound seniors requesting for home vaccination, AIC works with the relevant agencies to arrange for eligible seniors to be vaccinated at home.
Seniors who need support in getting vaccinated can contact the AIC hotline at 1800-650-6060, or their nearest SGO office.
mothership.sg
All seniors aged 60 and above, especially if they are unvaccinated, are strongly urged to stay at home for the next four weeks, given the recent rise in Covid-19 cases in Singapore.
Scroll to continue with content
This extends to those living with seniors above the age of 60, according to the Agency for Integrated Care (AIC).
Minimise eating at hawker centres
In a statement issued by AIC, seniors were encouraged to take added precautions to protect themselves, as they are at a higher risk of developing serious health complications if they are infected with Covid-19.More than a quarter of the local Covid-19 cases in the past two weeks were aged 60 and above, and from May 2021, there were 257 unvaccinated seniors who were severely affected by Covid-19, and were either in the intensive care unit (ICU), needed oxygen supplementation, or died.
In the next four weeks, seniors are encouraged to minimise group activities and social gatherings, and to minimise mask-off activities, such as eating at hawker centres, and opt for take-away food instead.
AIC also advised seniors to wear a surgical-grade mask properly at all times, and to maintain good hygiene practices, such as frequent hand washing.
Those who haven't been vaccinated should do so as soon as possible, said AIC, pointing out that the risk of an unvaccinated person getting severely ill is almost seven times higher, compared to a vaccinated person.
To minimise their exposure to other infections, seniors are also encouraged to visit hospitals only when necessary.
"If infected with Covid-19, with mild or no symptoms, they need not rush to hospital but can self-isolate at home for their own well-being," said AIC.
Seniors encouraged to get booster shots
AIC also encouraged seniors to take their Covid-19 booster shots, as seniors will benefit from the added protection to mitigate against waning immunity and help reduce the likelihood of severe illness if infected."This will position them well for transition to endemic Covid-19," said AIC.
The Covid-19 booster programme for seniors has begun since earlier this month.
AIC's outreach arm, the Silver Generation Office (SGO), has reached out to 670,000 seniors to share information about Covid-19 vaccination, and explain its benefits.
SSO will also make arrangements to escort seniors with mobility issues to vaccination centres.
For homebound seniors requesting for home vaccination, AIC works with the relevant agencies to arrange for eligible seniors to be vaccinated at home.
Seniors who need support in getting vaccinated can contact the AIC hotline at 1800-650-6060, or their nearest SGO office.
I think now don't need to report if no symptoms.
So many coviders in our community.
So many coviders in our community.
S'pore seniors aged 60 & above strongly urged to stay home next 4 weeks as Covid-19 cases surges - Mothership.SG
mothership.sg
All seniors aged 60 and above, especially if they are unvaccinated, are strongly urged to stay at home for the next four weeks, given the recent rise in Covid-19 cases in Singapore.
Scroll to continue with content
This extends to those living with seniors above the age of 60, according to the Agency for Integrated Care (AIC).
Minimise eating at hawker centres
In a statement issued by AIC, seniors were encouraged to take added precautions to protect themselves, as they are at a higher risk of developing serious health complications if they are infected with Covid-19.
More than a quarter of the local Covid-19 cases in the past two weeks were aged 60 and above, and from May 2021, there were 257 unvaccinated seniors who were severely affected by Covid-19, and were either in the intensive care unit (ICU), needed oxygen supplementation, or died.
In the next four weeks, seniors are encouraged to minimise group activities and social gatherings, and to minimise mask-off activities, such as eating at hawker centres, and opt for take-away food instead.
AIC also advised seniors to wear a surgical-grade mask properly at all times, and to maintain good hygiene practices, such as frequent hand washing.
Those who haven't been vaccinated should do so as soon as possible, said AIC, pointing out that the risk of an unvaccinated person getting severely ill is almost seven times higher, compared to a vaccinated person.
To minimise their exposure to other infections, seniors are also encouraged to visit hospitals only when necessary.
"If infected with Covid-19, with mild or no symptoms, they need not rush to hospital but can self-isolate at home for their own well-being," said AIC.
Seniors encouraged to get booster shots
AIC also encouraged seniors to take their Covid-19 booster shots, as seniors will benefit from the added protection to mitigate against waning immunity and help reduce the likelihood of severe illness if infected.
"This will position them well for transition to endemic Covid-19," said AIC.
The Covid-19 booster programme for seniors has begun since earlier this month.
AIC's outreach arm, the Silver Generation Office (SGO), has reached out to 670,000 seniors to share information about Covid-19 vaccination, and explain its benefits.
SSO will also make arrangements to escort seniors with mobility issues to vaccination centres.
For homebound seniors requesting for home vaccination, AIC works with the relevant agencies to arrange for eligible seniors to be vaccinated at home.
Seniors who need support in getting vaccinated can contact the AIC hotline at 1800-650-6060, or their nearest SGO office.
All above 60 must WFH?
Singaporeans quite poor thing, most still working in their 60s.
It means there's many silent carriers around liao.....and my laupeh and brother are among them.
The rules keep changing everyday. Last week you have to take an exit PCR test to make sure you're negative before they remove the QO. Right now if you are tested positive, you self-quarantine for 10 days and ownself discharge ownself if you are feeling well, no need exit PCR test liao. You won't even get MOH sms to tell you that your QO is over. I bet it will be a different rule tomorrow.
It's the constant rule-changing that is making people anxious and confused because you never know if you are breaking the law under the Infectious Disease Act.
Many cleaners covided in Sept.
Now over 60 recommended to stay home, cleaning industry will be affected.
Now over 60 recommended to stay home, cleaning industry will be affected.
Bookmarked.
For any one young and healthy, covid is nothing more than losing taste and schmell for a few days. There is no need to inject freaky fluids in to your body, u silliterate fool.
Old people are willingly going to their deaths by vaxxing nation so ingrates can dine in fancy restaurants!
Today is the last day of the month.
By tonight, about half of Singapore's accumulated COVID death toll in the past 2 years are from September 2021.
By tonight, about half of Singapore's accumulated COVID death toll in the past 2 years are from September 2021.
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