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[COVID-19 Virus] The Sinkies are fucked Thread.
- Thread starter zhihau
- Start date
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The vaccinated ones don't know how lucky they are... they can dine-in now.
Better do it more often, because many of the restaurants, cafes and bars will be kaput in the near future. Food delivery services will not save them.
Take more photos, make more happy memories... although group size restrictions will diminish your enjoyment.
Better do it more often, because many of the restaurants, cafes and bars will be kaput in the near future. Food delivery services will not save them.
Take more photos, make more happy memories... although group size restrictions will diminish your enjoyment.
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I was looking at 5-digit daily increments at the end of October if the new restrictions hasn’t kick in on 27Sep.
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It's the oldest trick in the book for covering backside: pre-emptively releasing or leaking some exaggerated projection of bad news (in this case, up to 5k cases daily) to psychologically prime the daft Sinkies, so when there are 3k or 4k cases daily, it doesn't seem that bad i.e. 'give me credit for I am competent'.
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It’s similar with charging sky high prices for pigeon holes then give rebates, more shiok shiok.It's the oldest trick in the book for covering backside: pre-emptively releasing or leaking some exaggerated projection of bad news (in this case, up to 5k cases daily) to psychologically prime the daft Sinkies, so when there are 3k or 4k cases daily, it doesn't seem that bad i.e. 'give me credit for I am competent'.
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i dun see how lucky they are if i look at biology and science.
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We are blacklisted across the globe. Which foreigner will come and be stuck here? Stupid fahtasies
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Many of their shit lies article can just be under the headline i am useles, therefore...It's the oldest trick in the book for covering backside: pre-emptively releasing or leaking some exaggerated projection of bad news (in this case, up to 5k cases daily) to psychologically prime the daft Sinkies, so when there are 3k or 4k cases daily, it doesn't seem that bad i.e. 'give me credit for I am competent'.
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reverse psychologyIt's the oldest trick in the book for covering backside: pre-emptively releasing or leaking some exaggerated projection of bad news (in this case, up to 5k cases daily) to psychologically prime the daft Sinkies, so when there are 3k or 4k cases daily, it doesn't seem that bad i.e. 'give me credit for I am competent'.
- Joined
- Aug 7, 2008
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It's just a normal flu and we have achieved a high vaccination rate. They should just save themselves from embarrassment and stop all these daily counts and forecasts.
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- Dec 6, 2012
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Same like lao gin fasterest to say I'm normal looking auntie firstIt's the oldest trick in the book for covering backside: pre-emptively releasing or leaking some exaggerated projection of bad news (in this case, up to 5k cases daily) to psychologically prime the daft Sinkies, so when there are 3k or 4k cases daily, it doesn't seem that bad i.e. 'give me credit for I am competent'.
- Joined
- Mar 31, 2020
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A daily pill to treat Covid could be just months away, scientists say
Within a day of testing positive for Covid-19 in June, Miranda Kelly was sick enough to be scared. At 44, with diabetes and high blood pressure, Kelly, a certified nursing assistant, was having trouble breathing, symptoms serious enough to send her to the emergency room.
When her husband, Joe, 46, fell ill with the virus, too, she really got worried, especially about their five teenagers at home: “I thought: ‘I hope to God we don’t wind up on ventilators. We have children. Who’s going to raise these kids?’”
But the Kellys, who live in Seattle, had agreed just after their diagnoses to join a clinical trial at the nearby Fred Hutchinson Cancer Research Center that’s part of an international effort to test an antiviral treatment that could halt Covid early in its course.
By the next day, the couple were taking four pills, twice a day. Although they weren’t told whether they had received an active medication or a placebo, within a week, they said, their symptoms were better. Within two weeks, they had recovered.
“I don’t know if we got the treatment, but I kind of feel like we did,” Miranda Kelly said. “To have all these underlying conditions, I felt like the recovery was very quick.”
The Kellys have a role in developing what could be the world’s next chance to thwart Covid: a short-term regimen of daily pills that can fight the virus early after diagnosis and conceivably prevent symptoms from developing after exposure.
“Oral antivirals have the potential to not only curtail the duration of one’s Covid-19 syndrome, but also have the potential to limit transmission to people in your household if you are sick,” said Timothy Sheahan, a virologist at the University of North Carolina-Chapel Hill who has helped pioneer the therapies.
Antivirals are already essential treatments for other viral infections, including hepatitis C and HIV. One of the best known is Tamiflu, the widely prescribed pill that can shorten the duration of influenza and reduce the risk of hospitalization if it is given quickly.
The medications, developed to treat and prevent viral infections in people and animals, work differently depending on the type. But they can be engineered to boost the immune system to fight infection, block receptors so viruses can’t enter healthy cells or lower the amount of active virus in the body.
At least three promising antivirals for Covid are being tested in clinical trials, with results expected as soon as late fall or winter, said Carl Dieffenbach, director of the Division of AIDS at the National Institute of Allergy and Infectious Diseases, who is overseeing antiviral development.
“I think that we will have answers as to what these pills are capable of within the next several months,” Dieffenbach said.
The top contender is a medication from Merck & Co. and Ridgeback Biotherapeutics called molnupiravir, Dieffenbach said. That is the product being tested in the Kellys’ Seattle trial.
Two others are a candidate from Pfizer, known as PF-07321332, and AT-527, an antiviral produced by Roche and Atea Pharmaceuticals.
They work by interfering with the virus’s ability to replicate in human cells. In the case of molnupiravir, the enzyme that copies the viral genetic material is forced to make so many mistakes that the virus can’t reproduce. That, in turn, reduces a patient’s viral load, shortening infection time and preventing the kind of dangerous immune response that can cause serious illness or death.
So far, only one antiviral drug, remdesivir, has been approved to treat Covid. But it is given intravenously to patients ill enough to be hospitalized, and it isn’t intended for early, widespread use. By contrast, the top contenders under study can be packaged as pills.
Sheahan, who also performed preclinical work on remdesivir, led an early study in mice that showed that molnupiravir could prevent early disease caused by SARS-CoV-2, the virus that causes Covid. The formula was discovered at Emory University and later acquired by Ridgeback and Merck.
Clinical trials have followed, including an early trial of 202 participants last spring that showed that molnupiravir rapidly reduced the levels of infectious virus. Merck Chief Executive Robert Davis said this month that the company expects data from its larger phase 3 trials in the coming weeks, with the potential to seek emergency use authorization from the Food and Drug Administration “before year-end.”
Pfizer launched a combined phase 2 and 3 trial of its product Sept. 1, and Atea officials said they expect results from phase 2 and phase 3 trials later this year.
If the results are positive and emergency use is granted for any product, Dieffenbach said, “distribution could begin quickly.”
That would mean millions of people soon could have access to a daily orally administered medication, ideally a single pill, that could be taken for five to 10 days at the first confirmation of Covid infection.
“When we get there, that’s the idea,” said Dr. Daniel Griffin, an infectious diseases and immunology expert at Columbia University. “To have this all around the country, so that people get it the same day they get diagnosed.”
Once sidelined for lack of interest, oral antivirals to treat coronavirus infections are now a subject of fierce competition and funding. In June, the Biden administration announced that it had agreed to obtain about 1.7 million treatment courses of Merck’s molnupiravir, at a cost of $1.2 billion, if the product receives emergency authorization or full approval. The same month, the administration said it would invest $3.2 billion in the Antiviral Program for Pandemics, which aims to develop antivirals for the Covid crisis and beyond, Dieffenbach said.
The pandemic kick-started a long-neglected effort to develop potent antiviral treatments for coronaviruses, Sheahan said. Although the original SARS virus in 2003 gave scientists a scare — followed by Middle East respiratory syndrome, or MERS, in 2012 — research efforts slowed when the outbreaks didn’t persist.
“The commercial drive to develop any products just went down the tubes,” Sheahan said.
Widely available antiviral drugs would join the monoclonal antibody therapies already used to treat and prevent serious illness and hospitalizations caused by Covid. The lab-produced monoclonal antibodies, which mimic the body’s natural response to infection, were easier to develop but must be given primarily through intravenous infusions.
The federal government is covering the cost of most monoclonal products at $2,000 a dose. It’s still too early to know how the price of antivirals might compare.
Like the monoclonal antibodies, antiviral pills would be no substitute for vaccination, Griffin said. They would be another tool to fight Covid. “It’s nice to have another option,” he said.
A challenge in developing antiviral drugs quickly has been recruiting enough participants for the clinical trials, each of which needs to enroll many hundreds of people, said Dr. Elizabeth Duke, a Fred Hutch research associate overseeing its molnupiravir trial.
Participants must be unvaccinated and enrolled in the trial within five days of positive Covid tests. Any given day, interns make 100 calls to newly Covid-positive people in the Seattle area — and most say no.
“Just generally speaking, there’s a lot of mistrust about the scientific process,” Duke said. “And some of the people are saying kind of nasty things to the interns.”
If the antiviral pills prove effective, the next challenge will be to ramp up a distribution system that can rush them to people as soon as they test positive. Griffin said it will take something akin to the program set up last year by UnitedHealthcare, which sped Tamiflu kits to 200,000 at-risk patients enrolled in the insurer’s Medicare Advantage plans.
Merck officials predicted that the company could produce more than 10 million courses of therapy by the end of the year. Atea and Pfizer haven’t released similar estimates.
Even more promising? Studies evaluating whether antivirals can prevent infection after exposure.
“Think about that,” said Duke, who is also overseeing a prophylactic trial. “You could give it to everyone in a household or everyone in a school. Then we’re talking about a return to, maybe, normal life.”
Within a day of testing positive for Covid-19 in June, Miranda Kelly was sick enough to be scared. At 44, with diabetes and high blood pressure, Kelly, a certified nursing assistant, was having trouble breathing, symptoms serious enough to send her to the emergency room.
When her husband, Joe, 46, fell ill with the virus, too, she really got worried, especially about their five teenagers at home: “I thought: ‘I hope to God we don’t wind up on ventilators. We have children. Who’s going to raise these kids?’”
But the Kellys, who live in Seattle, had agreed just after their diagnoses to join a clinical trial at the nearby Fred Hutchinson Cancer Research Center that’s part of an international effort to test an antiviral treatment that could halt Covid early in its course.
By the next day, the couple were taking four pills, twice a day. Although they weren’t told whether they had received an active medication or a placebo, within a week, they said, their symptoms were better. Within two weeks, they had recovered.
“I don’t know if we got the treatment, but I kind of feel like we did,” Miranda Kelly said. “To have all these underlying conditions, I felt like the recovery was very quick.”
The Kellys have a role in developing what could be the world’s next chance to thwart Covid: a short-term regimen of daily pills that can fight the virus early after diagnosis and conceivably prevent symptoms from developing after exposure.
“Oral antivirals have the potential to not only curtail the duration of one’s Covid-19 syndrome, but also have the potential to limit transmission to people in your household if you are sick,” said Timothy Sheahan, a virologist at the University of North Carolina-Chapel Hill who has helped pioneer the therapies.
Antivirals are already essential treatments for other viral infections, including hepatitis C and HIV. One of the best known is Tamiflu, the widely prescribed pill that can shorten the duration of influenza and reduce the risk of hospitalization if it is given quickly.
The medications, developed to treat and prevent viral infections in people and animals, work differently depending on the type. But they can be engineered to boost the immune system to fight infection, block receptors so viruses can’t enter healthy cells or lower the amount of active virus in the body.
At least three promising antivirals for Covid are being tested in clinical trials, with results expected as soon as late fall or winter, said Carl Dieffenbach, director of the Division of AIDS at the National Institute of Allergy and Infectious Diseases, who is overseeing antiviral development.
“I think that we will have answers as to what these pills are capable of within the next several months,” Dieffenbach said.
The top contender is a medication from Merck & Co. and Ridgeback Biotherapeutics called molnupiravir, Dieffenbach said. That is the product being tested in the Kellys’ Seattle trial.
Two others are a candidate from Pfizer, known as PF-07321332, and AT-527, an antiviral produced by Roche and Atea Pharmaceuticals.
They work by interfering with the virus’s ability to replicate in human cells. In the case of molnupiravir, the enzyme that copies the viral genetic material is forced to make so many mistakes that the virus can’t reproduce. That, in turn, reduces a patient’s viral load, shortening infection time and preventing the kind of dangerous immune response that can cause serious illness or death.
So far, only one antiviral drug, remdesivir, has been approved to treat Covid. But it is given intravenously to patients ill enough to be hospitalized, and it isn’t intended for early, widespread use. By contrast, the top contenders under study can be packaged as pills.
Sheahan, who also performed preclinical work on remdesivir, led an early study in mice that showed that molnupiravir could prevent early disease caused by SARS-CoV-2, the virus that causes Covid. The formula was discovered at Emory University and later acquired by Ridgeback and Merck.
Clinical trials have followed, including an early trial of 202 participants last spring that showed that molnupiravir rapidly reduced the levels of infectious virus. Merck Chief Executive Robert Davis said this month that the company expects data from its larger phase 3 trials in the coming weeks, with the potential to seek emergency use authorization from the Food and Drug Administration “before year-end.”
Pfizer launched a combined phase 2 and 3 trial of its product Sept. 1, and Atea officials said they expect results from phase 2 and phase 3 trials later this year.
If the results are positive and emergency use is granted for any product, Dieffenbach said, “distribution could begin quickly.”
That would mean millions of people soon could have access to a daily orally administered medication, ideally a single pill, that could be taken for five to 10 days at the first confirmation of Covid infection.
“When we get there, that’s the idea,” said Dr. Daniel Griffin, an infectious diseases and immunology expert at Columbia University. “To have this all around the country, so that people get it the same day they get diagnosed.”
Once sidelined for lack of interest, oral antivirals to treat coronavirus infections are now a subject of fierce competition and funding. In June, the Biden administration announced that it had agreed to obtain about 1.7 million treatment courses of Merck’s molnupiravir, at a cost of $1.2 billion, if the product receives emergency authorization or full approval. The same month, the administration said it would invest $3.2 billion in the Antiviral Program for Pandemics, which aims to develop antivirals for the Covid crisis and beyond, Dieffenbach said.
The pandemic kick-started a long-neglected effort to develop potent antiviral treatments for coronaviruses, Sheahan said. Although the original SARS virus in 2003 gave scientists a scare — followed by Middle East respiratory syndrome, or MERS, in 2012 — research efforts slowed when the outbreaks didn’t persist.
“The commercial drive to develop any products just went down the tubes,” Sheahan said.
Widely available antiviral drugs would join the monoclonal antibody therapies already used to treat and prevent serious illness and hospitalizations caused by Covid. The lab-produced monoclonal antibodies, which mimic the body’s natural response to infection, were easier to develop but must be given primarily through intravenous infusions.
The federal government is covering the cost of most monoclonal products at $2,000 a dose. It’s still too early to know how the price of antivirals might compare.
Like the monoclonal antibodies, antiviral pills would be no substitute for vaccination, Griffin said. They would be another tool to fight Covid. “It’s nice to have another option,” he said.
A challenge in developing antiviral drugs quickly has been recruiting enough participants for the clinical trials, each of which needs to enroll many hundreds of people, said Dr. Elizabeth Duke, a Fred Hutch research associate overseeing its molnupiravir trial.
Participants must be unvaccinated and enrolled in the trial within five days of positive Covid tests. Any given day, interns make 100 calls to newly Covid-positive people in the Seattle area — and most say no.
“Just generally speaking, there’s a lot of mistrust about the scientific process,” Duke said. “And some of the people are saying kind of nasty things to the interns.”
If the antiviral pills prove effective, the next challenge will be to ramp up a distribution system that can rush them to people as soon as they test positive. Griffin said it will take something akin to the program set up last year by UnitedHealthcare, which sped Tamiflu kits to 200,000 at-risk patients enrolled in the insurer’s Medicare Advantage plans.
Merck officials predicted that the company could produce more than 10 million courses of therapy by the end of the year. Atea and Pfizer haven’t released similar estimates.
Even more promising? Studies evaluating whether antivirals can prevent infection after exposure.
“Think about that,” said Duke, who is also overseeing a prophylactic trial. “You could give it to everyone in a household or everyone in a school. Then we’re talking about a return to, maybe, normal life.”
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Go virus go. 加油。
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My uncle fasterer said he got karchng bin to hope for a upgrade to normal bin while lao gin fastetest said normal and hope for a upgrade to good looking KNN that's human nature KNNSame like lao gin fasterest to say I'm normal looking auntie first
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maybe sinkypura moh home recovery prog will result in this type of jiuhu case soon....
Father and son found dead at home, cops suspect Covid-19
By Aizat Sharif - September 26, 2021 @ 2:43pmKANGAR: Police suspect the deaths of two men whose bodies were found at their residence in Taman Dato Setia here today were due to Covid-19 infection.
Kangar District Police Chief Superintendent Wari Kiew said the police found the bodies of the two men, aged 53 and 79, after being informed by the victim's contact at around 4.33pm after failing to reach the victims for the past few days.
"Police officers who arrived at the single-storey bungalow house found that the door was closed but not locked.
"Further examination found the two bodies in the house believed to be father and son, where the son's body was bloated, suspected to have died a few days ago.
"The body of the elderly man, believed to be the father as found lying in the dining room of the house in normal condition," he said in a statement, today.
He said health workers from the Tuanku Fauziah Hospital (HTF), Kangar then arrived to examine the bodies.
"We did not find any criminal act against the victims. However, a thorough examination could not be performed because it was feared that the victims were infected with the Covid-19 virus.
"The victim's wife was also found unconscious in the house and was taken to HTF for further examination as she was suspected of suffering from depression," he said.
He said the victims' bodies were taken to the HTF Forensic Unit to be checked for Covid-19 infection and the case has been classified as sudden death.
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1536 community
398 dorm
5 imported
There were 1939 new confirmed cases of 2019-nCoV in the local area, and community cases accounted for 1,536, all reaching new highs.
According to an evening statement from the Ministry of Health, as of 12 noon today (26th), community cases have exceeded 1,000 for six consecutive days, with 1,536 reported, 398 guest worker dormitory cases, and five imported cases.
Among the community cases, 417 were seniors over 60 years old, and as many as 97 were children under 12 years old.
The cumulative number of local cases has now reached 87,892.
398 dorm
5 imported
There were 1939 new confirmed cases of 2019-nCoV in the local area, and community cases accounted for 1,536, all reaching new highs.
According to an evening statement from the Ministry of Health, as of 12 noon today (26th), community cases have exceeded 1,000 for six consecutive days, with 1,536 reported, 398 guest worker dormitory cases, and five imported cases.
Among the community cases, 417 were seniors over 60 years old, and as many as 97 were children under 12 years old.
The cumulative number of local cases has now reached 87,892.
- Joined
- Jul 10, 2008
- Messages
- 35,566
- Points
- 113
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