many eagerly await?
Well, I also eagerly await many bastards around me to take the jabs as often as possible.
Well, I also eagerly await many bastards around me to take the jabs as often as possible.
-
IP addresses are NOT logged in this forum so there's no point asking. Please note that this forum is full of homophobes, racists, lunatics, schizophrenics & absolute nut jobs with a smattering of geniuses, Chinese chauvinists, Moderate Muslims and last but not least a couple of "know-it-alls" constantly sprouting their dubious wisdom. If you believe that content generated by unsavory characters might cause you offense PLEASE LEAVE NOW! Sammyboy Admin and Staff are not responsible for your hurt feelings should you choose to read any of the content here. The OTHER forum is HERE so please stop asking.
[Sg] - Singaporeans eagerly await the arrival of Moderna's 2-in-1 combo vaccine for Covid & Influenza to get vaccinated asap
- Thread starter UltimaOnline
- Start date
Actually I'm looking forward to seeing people dropping dead like flies around me.
My camera is always ready to capture these idiot's last breaths.
My camera is always ready to capture these idiot's last breaths.
Same here. And never got tested. Many vaxxed gongkias and gong CBs still do regular testing even when they feel fine.
The number of male youths under 18 getting heart issues (as revealed in echocardio, ECG, threadmill stress tests), increased in 2023 and 2024. Frontline medical professionals do not treat such observations lightly, but the increment is like a norm now and some cardios classify many them as "benign" to avoid downgrading their PES.
Children & Youth don't really have heart issues, but we are now lowering the bar when abnormalities are identified.
Children & Youth don't really have heart issues, but we are now lowering the bar when abnormalities are identified.
Me also two years never wear masks, my colleagues who wear masks in office dunno sick how many times already.Same here. And never got tested. Many vaxxed gongkias and gong CBs still do regular testing even when they feel fine.
Oh Well we haven't heard of any aggressors or victims in the Israel or Russia war asking for Covid 19 vaccine no?
I only wore a mask during the height of the scamdemic, because the cost of not doing so would be a fine.
When will we get mrna Viagra?
Our wanabe hollywood actors/actress will be mobilised, to spread the vaccination news. Which one is your favourite celebrities?
Deaths are low in "drugs" like Ivermectin because of low consumption. Thankfully, very few people are dumb enough to take Ivermectin. This is what I mean when you take stats to suit your argument and spread misinformation.
Boss Sam, you never take maths in school and don't understand basic percentage? If 100 people take Ivermectin and 50 die, mortality is 50%. If 4 billion people take the vaccine and 36K die. what is the percentage?
Not something to improve sex lives but used for something more important.
While the morons here are bitching day in day out about something their small brains cannot understand, the world of science has moved on with mRNA to bigger things than just a successful vaccine for COVID.
New mRNA cancer vaccine triggers fierce immune response to fight malignant brain tumor
May 1, 2024•
By Michelle Jaffee
•
Media Contact
•
Share
Dr. Elias Sayour, Chong Zhao and Arnav Barpujari discuss the mRNA cancer vaccine developed at the University of Florida.
Play Video
In a first-ever human clinical trial of four adult patients, an mRNA cancer vaccine developed at the University of Florida quickly reprogrammed the immune system to attack glioblastoma, the most aggressive and lethal brain tumor.
The results mirror those in 10 pet dog patients suffering from naturally occurring brain tumors whose owners approved of their participation, as they had no other treatment options, as well as results from preclinical mouse models. The breakthrough now will be tested in a Phase 1 pediatric clinical trial for brain cancer.
Reported May 1 in the journal Cell, the discovery represents a potential new way to recruit the immune system to fight notoriously treatment-resistant cancers using an iteration of mRNA technology and lipid nanoparticles, similar to COVID-19 vaccines, but with two key differences: use of a patient’s own tumor cells to create a personalized vaccine, and a newly engineered complex delivery mechanism within the vaccine.
“Instead of us injecting single particles, we’re injecting clusters of particles that are wrapping around each other like onions, like a bag full of onions,” said senior author Elias Sayour, M.D., Ph.D., a UF Health pediatric oncologist who pioneered the new vaccine, which like other immunotherapies attempts to “educate” the immune system that a tumor is foreign. “And the reason we’ve done that in the context of cancer is these clusters alert the immune system in a much more profound way than single particles would.”
Sadeem Qdaisat, Dr. Hector Mendez-Gomez and Dr. Elias Sayour discuss their new study. (Photo by Nate Guidry)Among the most impressive findings was how quickly the new method, delivered intravenously, spurred a vigorous immune-system response to reject the tumor, said Sayour, principal investigator of the RNA Engineering Laboratory within UF’s Preston A. Wells Jr. Center for Brain Tumor Therapy and a UF Health Cancer Center and McKnight Brain Institute investigator who led the multi-institution research team.
“In less than 48 hours, we could see these tumors shifting from what we refer to as ‘cold’ — immune cold, very few immune cells, very silenced immune response — to ‘hot,’ very active immune response,” he said. “That was very surprising given how quick this happened, and what that told us is we were able to activate the early part of the immune system very rapidly against these cancers, and that’s critical to unlock the later effects of the immune response.”
Glioblastoma is among the most devastating diagnoses, with median survival around 15 months. Current standard of care involves surgery, radiation and some combination of chemotherapy.
The new publication is the culmination of promising translational results over seven years of studies, starting in preclinical mouse models and then in a clinical trial of 10 pet dogs that had spontaneously developed terminal brain cancer and had no other treatment options. That trial was conducted with owners’ consent in collaboration with the UF College of Veterinary Medicine. Dogs offer a naturally occurring model for malignant glioma because they are the only other species that develops spontaneous brain tumors with some frequency, said Sheila Carrera-Justiz, D.V.M., a veterinary neurologist at the UF College of Veterinary Medicine who is partnering with Sayour on the clinical trials. Gliomas in dogs are universally terminal, she said.
After treating pet dogs that had spontaneously developed brain cancer with personalized mRNA vaccines, Sayour’s team advanced the research to a small Food and Drug Administration-approved clinical trial designed to ensure safety and test feasibility before expanding to a larger trial.
In a cohort of four patients, genetic material called RNA was extracted from each patient’s own surgically removed tumor, and then messenger RNA, or mRNA — the blueprint of what is inside every cell, including tumor cells — was amplified and wrapped in the newly designed high-tech packaging of biocompatible lipid nanoparticles, to make tumor cells “look” like a dangerous virus when reinjected into the bloodstream and prompt an immune-system response. The vaccine was personalized to each patient with a goal of getting the most out of their unique immune system.
“The demonstration that making an mRNA cancer vaccine in this fashion generates similar and strong responses across mice, pet dogs that have developed cancer spontaneously and human patients with brain cancer is a really important finding, because oftentimes we don’t know how well the preclinical studies in animals are going to translate into similar responses in patients,” said Duane Mitchell, M.D., Ph.D., director of the UF Clinical and Translational Science Institute and the UF Brain Tumor Immunotherapy Program and a co-author of the paper. “And while mRNA vaccines and therapeutics are certainly a hot topic since the COVID pandemic, this is a novel and unique way of delivering the mRNA to generate these really significant and rapid immune responses that we’re seeing across animals and humans.”
Dr. Duane Mitchell, Jeet Patel and Dr. Christina von Roemeling in the Adam Michael Rosen Neuro-oncology Laboratories. (Photo by Nate Guidry)While too early in the trial to assess the clinical effects of the vaccine, the patients either lived disease-free longer than expected or survived longer than expected.
The 10 pet dogs lived a median of 139 days, compared with a median survival of 30 to 60 days typical for dogs with the condition.
The next step, through support from the Food and Drug Administration and the CureSearch for Children’s Cancer foundation, will be an expanded Phase I clinical trial to include up to 24 adult and pediatric patients to validate the findings. Once an optimal and safe dose is confirmed, an estimated 25 children would participate in Phase 2, said Sayour, an associate professor in the Lillian S. Wells Department of Neurosurgery and the department of pediatrics in the UF College of Medicine, part of UF Health.
For the new clinical trial, Sayour’s lab will partner with a multi-institution consortium, the Pediatric Neuro-Oncology Consortium, to send the immunotherapy treatment to children’s hospitals across the country. They will do this by receiving an individual patient’s tumor, manufacturing the personalized vaccine at UF and sending it back to the patient’s medical team, said Sayour, co-leader of the Immuno-Oncology and Microbiome research program at the UF Health Cancer Center.
Despite the promising results, the authors said one limitation is continued uncertainty about how best to harness the immune system while minimizing the potential for adverse side effects.
“I am hopeful that this could be a new paradigm for how we treat patients, a new platform technology for how we can modulate the immune system,” said Sayour, the Stop Children's Cancer/Bonnie R. Freeman Professor for Pediatric Oncology Research. “I am hopeful for how this could now synergize with other immunotherapies and perhaps unlock those immunotherapies. We showed in this paper that you actually can have synergy with other types of immunotherapies, so maybe now we can have a combination approach of immunotherapy.”
Sayour and Mitchell hold patents related to the vaccine which are under option to license by iOncologi Inc., a biotech company born as a “spin out” from UF in which Mitchell holds interest.
This is cringe. I guess propaganda pays good shekels to these washed up Mediacock showbiz floozies.
Similar threads
