When the bridge was completed, it became the world's longest arch bridge, surpassing the earlier title holder, the New River Gorge Bridge.
An inauguration ceremony was held on June 27, 2003, featuring a group of runners, including Yao Ming, who were the first to cross the bridge. The bridge opened to vehicular traffic the next day.
In 2009, Lupu Bridge lost its title of the world's longest arch bridge to the Chaotianmen Bridge in Chongqing. The longest span of the Chaotianmen Bridge was only 2 metres (7 ft) longer, at 552 metres (1,811 ft).
The Lupu Bridge was one of the architectural centerpieces of Expo 2010 in Shanghai, as it formed part of the western boundary of the Expo site.