Wow finally found something helpful for stomach cancer prevention and treatment: BERBERINE!

[ginfreely]

 

[ginfreely]

Gastric carcinoma (GC) is a complex multifactorial disease occurring as sequential events commonly referred to as the Correa’s cascade, a stepwise progression from non-active or chronic active gastritis, to gastric precancerous lesions, and finally, adenocarcinoma. Therefore, the identification of novel agents with multi-step actions on the Correa’s cascade and those functioning as multiple phenotypic regulators are the future direction for drug discovery. Recently, berberine (BBR) has gained traction owing to its pharmacological properties, including anti-inflammatory, anti-cancer, anti-ulcer, antibacterial, and immunopotentiation activities. In this article, we investigated and summarized the multi-step actions of BBR on Correa’s cascade and its underlying regulatory mechanism in gastric carcinogenesis for the first time, along with a discussion on the strength of BBR to prevent and treat GC. BBR was found to suppress H. pylori infection, control mucosal inflammation, and promote ulcer healing. In the gastric precancerous lesion phase, BBR could reverse mucosal atrophy and prevent lesions in intestinal metaplasia and dysplasiaby regulating inflammatory cytokines, promoting cell apoptosis, regulating macrophage polarization, and regulating autophagy. Additionally, the therapeutic action of BBR on GC was partly realized through the inhibition of cell proliferation, migration, and angiogenesis; induction of apoptosis and autophagy, and enhancement of chemotherapeutic drug sensitivity. BBR exerted multi-step actions on the Correa’s cascade, thereby halting and even reversing gastric carcinogenesis in some cases. Thus, BBR could be used to prevent and treat GC. In conclusion, the therapeutic strategy underlying BBR’s multi-step action in the trilogy of Correa’s cascade may include “prevention of gastric mucosal inflammation (Phase 1); reversal of gastric precancerous lesions (Phase 2), and rescue of GC (Phase 3)”. The NF-κB, PI3K/Akt, and MAPK signaling pathways may be the key signaling transduction pathways underlying the treatment of gastric carcinogenesis using BBR. The advantage of BBR over conventional drugs is its multifaceted and long-term effects. This review is expected to provide preclinical evidence for using BBR to prevent gastric carcinogenesis and treat gastric cancer.

 

[ginfreely]

Gastric carcinoma (GC) is a complex multifactorial disease occurring as sequential events commonly referred to as the Correa’s cascade, a stepwise progression from non-active or chronic active gastritis, to gastric precancerous lesions, and finally, adenocarcinoma.

What has this got to do with metabolism? Obviously genetics isn’t it?

 

[ginfreely]

What has this got to do with metabolism? Obviously genetics isn’t it?

Correa’s cascade..what a nice name.

 

[Balls2U]

Don't worry. You won't get stomach cancer. The amount of Bangla's cum you have consumed over the years will form a protective layer in your stomach killing all cancerous cells.

 

[ginfreely]

Don't worry. You won't get stomach cancer. The amount of Bangla's cum you have consumed over the years will form a protective layer in your stomach killing all cancerous cells.

Your shameless Cantonese whore mother and you then have consumed cum. Do evil to your BENEFACTOR with your Cantonese dog prostitute descendant pride. Pui!

 

[Cottonmouth]

Your cheebye is the area with cancer, the whole piece inside out. I suggest you cut it out and seal up the big hole.

 

[ginfreely]

Your shameless Cantonese whore mother and you then have consumed cum. Do evil to your BENEFACTOR with your Cantonese dog prostitute descendant pride. Pui!

Btw shameless evil ingrate Cantonese dog prostitute descendants like @Balls2U @musclepower @iamnobody @Cottonmouth etc etc don’t be so shameless to keep reading my good posts on cancer and benefiting from me your BENEFACTOR while doing evil defaming Gansiokbin hokkien virgin as slut whore mistress non stop. 低级中的低级贱中之贱 无耻之徒 indeed Pui!

 

[Cottonmouth]

Did you change your prostitution schedule? Why you wash your cheebye so early last night?

 

[ginfreely]

Did you change your prostitution schedule? Why you wash your cheebye so early last night?

You Loser Whore @empathizerofeatshitndie aka @Sinkie aka @glockman aka @Valium aka @CottonmouthAKA @ginmother Jeremy Quek of failure biz SUPERFUTUREKIDS, TINITECH CO and SKINNYFATKIDS WORLDWIDE hide in rat hole fabricate lies and photos of Gansiokbin to smear Gansiokbin a virgin as slut whore mistress to win Pui!​

JEREMY QUEK
- 50 years old Catholic
- Queenstown Secondary School 1986 to 1989. Dropout from Singapore Polytechnic and also dropout from Institute of Management UK, both pursued and dropout after one year. Jealous loser attacked Gansiokbin a scholar degree holder as he is jealous of degree holder.
- Said in his Tinitech co want to “build human dignity” but did degrading and inhumane treatment of Gansiokbin for years, almost a decade.
- Said in his Superfuturekids co “leveraging on data… .to serve human needs” while he hide in his rat hole stealing Gansiokbin data from name, address, NRIC number, short hair and face features to everything to smear and abuse Gansiokbin, everyday spewing evil filthy lies to insult Gansiokbin and use a short hair porn woman photo to label name and address to pass off as Gansiokbin and smear Gansiokbin as slut whore mistress.
- Do prayer psalm 130 5 6 “more than just a watchman for daybreak” to seek assurance of forgiveness from God to let him go heaven despite doing daily smearing and abuse of Gansiokbin.
- Condemned “thieving muddled as creativity” in LinkedIn AND condemned people that think thieving is brilliant and cool yet ownself everyday and for years so proud of thieving Gansiokbin data and fabricated evil filthy lies and photos of Gansiokbin to smear Gansiokbin a virgin as slut whore mistress as if that’s creativity, cool and brilliant.
- Self claimed in LinkedIn that he is “not an asshole and one of the nicest people you will ever meet” while he everyday hide in rat hole to abuse, smear, trample and insult Gansiokbin a virgin as slut whore mistress.
- Despicable dog asshole criminal son of Cantonese whore that started threads - and use his clone @ginmother etc - to start threads smearing Gansiokbin a virgin as slut whore mistress to dirty Gansiokbin google search result and then after that turned around to accuse Gansiokbin is dirty prostitute and that’s why google search is dirty

 

[Cottonmouth]

Did you forget to wash your cheebye on 7 Feb 2024??

 

[Cottonmouth]

@ginfreely i suggest you use the toilet brush and bleach for your hole.

 

[Cottonmouth]

 

[ginfreely]

What a fucking disgrace you Asian dog Jeremy Quek son of Cantonese prostitute smearing and harassing hokkien virgin as slut whore mistress non stop Pui!

 

[ginfreely]

View attachment 195154

Okay natural product ordered!