Pfizer's COVID-19 protection against infection may wane in months, but it still prevents hospitalization and death for at least 6, new studies suggest

[LittleP]

https://news.yahoo.com/pfizers-covid-19-immunity-protection-032404881.html

• A study from Qatar found protection against asymptomatic infection with Pfizer's vaccine declines a few months after the second dose.
• Another Pfizer study from Israel showed neutralizing antibodies waning dramatically after 6 months.
• But Pfizer's protection against severe disease and death is still well over 90% for at least 6 months.

People who get Pfizer's two-shot vaccine may still catch COVID-19 in the months after they are fully vaccinated - though those infections may be so mild they fly entirely under the radar.

Two new studies, published in the New England Journal of Medicine on Wednesday, show that Pfizer's mRNA shots still remain effective in guarding against hospitalization and death for at least six months, though protection against milder disease as well as antibody levels can fall - or at least they did in the face of the Beta and Delta variants.

The new findings affirm what Pfizer, Moderna, and the Centers for Disease Control and Prevention have indicated in recent weeks - that the mRNA vaccines' ability to protect the body from coronavirus infection may wane over time, meriting a third shot.

Strong protection against the worst things COVID-19 can do persisted for at least half a year​

A man receives a COVID-19 vaccine at a mass vaccination site in Doha on February 18, 2021. Karim Jaafar/AFP via Getty Images
In the first study, researchers in Qatar (a highly inoculated country with more than 82% of people fully vaccinated) investigated more than 900,000 PCR tests of people vaccinated with Pfizer (the most popular shot there), and found that their protection against any infection started to decrease markedly about four months after their second jab.

The researchers found that Pfizer's protection against infection was "negligible" just after a first dose, rising to 36.8% three weeks later. When people then received their second shot, their vaccine protection jumped to 77.5% within about four weeks, and protection against "any severe, critical, or fatal case of COVID-19 increased rapidly," the researchers said, reaching 96% or higher in the first two months that people were fully vaccinated.

That strong protection against the worst things COVID-19 can do to a person persisted for at least half a year.
"No evidence was found for an appreciable waning of protection against hospitalization and death, which remained robust - generally at 90% or higher - for 6 months after the second dose," the researchers said.

'Protection against asymptomatic infection diminished more quickly'​

Meanwhile, Pfizer's protection against milder and more negligible COVID-19 infections declined.
After people had been fully vaccinated for about five to seven months, the researchers observed Pfizer's vaccine effectiveness hovering around 20%, though only about a third of those infections were diagnosed "on the basis of symptoms," suggesting that many of them were silent, asymptomatic infections.
"Protection against asymptomatic infection diminished more quickly than that against symptomatic infection, as would be expected in a vaccine that prevents symptoms," the researchers said. "These findings suggest that a large proportion of the vaccinated population could lose its protection against infection in the coming months."
Other research from Qatar suggests that breakthough infections are less infectious than those in unvaccinated individuals, making them less likely to spread.
The second NEJM study, conducted in Israel, looked at 4,868 healthcare workers who'd been fully vaccinated with Pfizer's vaccine. It reported that their neutralizing antibodies to COVID-19 are "substantially" lowered by six months after receiving their second dose of Pfizer's vaccine - a trend that's especially true for men, people over age 65, and people with weakened immune systems.
Even so, only 20 of those healthcare workers had breakthrough infections during the study period, suggesting, again, that vaccine protection remains robust for many months after people get jabbed.
It's normal for neutralizing antibodies to decline after vaccination, and neutralizing antibodies are not the only element of immune response that protects us from reinfection, but vaccines for other conditions such as mumps, measles, and rubella only show small decreases of about 5% to 10% each year in neutralizing antibody levels, the researchers said.
Read the original article on Insider

https://news.yahoo.com/u-administers-more-400-million-202051985.html​

 

[mojito]

I hear regular exercise is even better.

 

[Peace Maker]

Do what is best for ourselves. Get vaccinated, stay healthy, reduce our stress & follow all covid 19 prevention measures. Stop blaming the government or anyone about mishandling the covid 19 situation, every country is also doing their best to get covid 19 under control. Of course, some countries manage it better than the rest. In any race or competition or handling of a disaster, there will always be winners & losers. The government can only do that much, a lot depends on the citizen's good cooperation. First world countries like Japan & USA reacted differently during national disasters. During tsunami in Japan 2011, Japanese help one another, even a safe found was returned intact to the rightful owner. During Hurricane Katrina, Americans were busy looting all the stores instead of helping one another. What makes a country depends on the people, stay united & we will overcome covid 19 some day.

 

[zhihau]

I hear regular exercise is even better.

Tantric sex is the BEST!

 

[porcaputtana]

Do what is best for ourselves. Get vaccinated, stay healthy, reduce our stress & follow all covid 19 prevention measures. Stop blaming the government or anyone about mishandling the covid 19 situation, every country is also doing their best to get covid 19 under control. Of course, some countries manage it better than the rest. In any race or competition or handling of a disaster, there will always be winners & losers. The government can only do that much, a lot depends on the citizen's good cooperation. First world countries like Japan & USA reacted differently during national disasters. During tsunami in Japan 2011, Japanese help one another, even a safe found was returned intact to the rightful owner. During Hurricane Katrina, Americans were busy looting all the stores instead of helping one another. What makes a country depends on the people, stay united & we will overcome covid 19 some day.

shit man

someone is gonna say you are my clone

 

[Peace Maker]

shit man

someone is gonna say you are my clone

Common, simple man think alike

 

[porcaputtana]

https://news.yahoo.com/pfizers-covid-19-immunity-protection-032404881.html

• A study from Qatar found protection against asymptomatic infection with Pfizer's vaccine declines a few months after the second dose.
• Another Pfizer study from Israel showed neutralizing antibodies waning dramatically after 6 months.
• But Pfizer's protection against severe disease and death is still well over 90% for at least 6 months.

People who get Pfizer's two-shot vaccine may still catch COVID-19 in the months after they are fully vaccinated - though those infections may be so mild they fly entirely under the radar.

Two new studies, published in the New England Journal of Medicine on Wednesday, show that Pfizer's mRNA shots still remain effective in guarding against hospitalization and death for at least six months, though protection against milder disease as well as antibody levels can fall - or at least they did in the face of the Beta and Delta variants.

The new findings affirm what Pfizer, Moderna, and the Centers for Disease Control and Prevention have indicated in recent weeks - that the mRNA vaccines' ability to protect the body from coronavirus infection may wane over time, meriting a third shot.

Strong protection against the worst things COVID-19 can do persisted for at least half a year​

A man receives a COVID-19 vaccine at a mass vaccination site in Doha on February 18, 2021. Karim Jaafar/AFP via Getty Images
In the first study, researchers in Qatar (a highly inoculated country with more than 82% of people fully vaccinated) investigated more than 900,000 PCR tests of people vaccinated with Pfizer (the most popular shot there), and found that their protection against any infection started to decrease markedly about four months after their second jab.

The researchers found that Pfizer's protection against infection was "negligible" just after a first dose, rising to 36.8% three weeks later. When people then received their second shot, their vaccine protection jumped to 77.5% within about four weeks, and protection against "any severe, critical, or fatal case of COVID-19 increased rapidly," the researchers said, reaching 96% or higher in the first two months that people were fully vaccinated.

That strong protection against the worst things COVID-19 can do to a person persisted for at least half a year.
"No evidence was found for an appreciable waning of protection against hospitalization and death, which remained robust - generally at 90% or higher - for 6 months after the second dose," the researchers said.

'Protection against asymptomatic infection diminished more quickly'​

Meanwhile, Pfizer's protection against milder and more negligible COVID-19 infections declined.
After people had been fully vaccinated for about five to seven months, the researchers observed Pfizer's vaccine effectiveness hovering around 20%, though only about a third of those infections were diagnosed "on the basis of symptoms," suggesting that many of them were silent, asymptomatic infections.
"Protection against asymptomatic infection diminished more quickly than that against symptomatic infection, as would be expected in a vaccine that prevents symptoms," the researchers said. "These findings suggest that a large proportion of the vaccinated population could lose its protection against infection in the coming months."
Other research from Qatar suggests that breakthough infections are less infectious than those in unvaccinated individuals, making them less likely to spread.
The second NEJM study, conducted in Israel, looked at 4,868 healthcare workers who'd been fully vaccinated with Pfizer's vaccine. It reported that their neutralizing antibodies to COVID-19 are "substantially" lowered by six months after receiving their second dose of Pfizer's vaccine - a trend that's especially true for men, people over age 65, and people with weakened immune systems.
Even so, only 20 of those healthcare workers had breakthrough infections during the study period, suggesting, again, that vaccine protection remains robust for many months after people get jabbed.
It's normal for neutralizing antibodies to decline after vaccination, and neutralizing antibodies are not the only element of immune response that protects us from reinfection, but vaccines for other conditions such as mumps, measles, and rubella only show small decreases of about 5% to 10% each year in neutralizing antibody levels, the researchers said.
Read the original article on Insider

https://news.yahoo.com/u-administers-more-400-million-202051985.html​

already well demonstrated in the Singapore model . mortality rate for the vaccinated is nearly negligible if no serious co existing morbidities

more peer review papers will emerge in the coming months to validate this fact

 

[porcaputtana]

Common, simple man think alike

unfortunately common sense is uncommon .

you can see the rabid anti vaxxers here tooting their fake science horn flying in the face of logic and common sense

but their days are numbered . government is going to make their lives really really unbearable .

 

[tobelightlight]

Two new studies, published in the New England Journal of Medicine on Wednesday, show that Pfizer's mRNA shots still remain effective in guarding against hospitalization and death for at least six months, though protection against milder disease as well as antibody levels can fall - or at least they did in the face of the Beta and Delta variants.

Did the study point out graphene oxide as its main ingredient in these vaccine? check my signature.

 

[JHolmesJr]

Someone should let them know that once you get caught lying, people have a hard time believing anything you say.
No matter who you are....

 

[porcaputtana]

Did the study point out graphene oxide as its main ingredient in these vaccine? check my signature.

https://www.reuters.com/article/factcheck-grapheneoxide-vaccine-idUSL1N2OZ14F

check real verified news you dumb piece of cow turd

 

[JHolmesJr]

Two new studies, published in the New England Journal of Medicine on Wednesday, show that Pfizer's mRNA shots still remain effective in guarding against hospitalization and death for at least six months....

"Guarding against" ..... LMAO! Da fuq is that?

This is the sort of claim designed specially for vaxxed people who are now wondering they went thru all those
risks and side effects for nothing. They're scared and confused because they were sold a lie.

Protects against infection
Prevents serious symptoms
Prevents hospitalisation and ICU
Prevents against the worst outcomes (death)

All turned out false....so now here's some more bullshit to feed the gullible.

There are double vaxxed people infected at all levels: asymptomatic, hospitalised, on O2, in ICU and dead.

So who is gonna buy this new snake oil? Obviously, the vaxxed up fucktards who desperately need
validation to smother the reality of a vaccine whose benefits are disappearing fast..

 

[porcaputtana]

Here we go … another one

but late to the game. You only have 10% of the population left to feed your deranged fake science

save your ammo for the next pandemic

 

[porcaputtana]

"Guarding against" ..... LMAO! Da fuq is that?

This is the sort of claim designed specially for vaxxed people who are now wondering they went thru all those
risks and side effects for nothing. They're scared and confused because they were sold a lie.

Protects against infection
Prevents serious symptoms
Prevents hospitalisation and ICU
Prevents against the worst outcomes (death)

All turned out false....so now here's some more bullshit to feed the gullible.

There are double vaxxed people infected at all levels: asymptomatic, hospitalised, on O2, in ICU and dead.

So who is gonna buy this new snake oil? Obviously, the vaxxed up fucktards who desperately need
validation to smother the reality of a vaccine whose benefits are disappearing fast..

https://www.channelnewsasia.com/asi...umes-covid-19-monday-vaccination-rate-2233701

oh look … even the mats won’t listen to you .

 

[rushifa666]

60% only. Fuck you. You want your body to fight both the vaccine and the virus at the saem timez.

 

[LittleP]

Health

How are COVID-19 vaccines faring over time? Here's what we know about waning immunity​

ABC Health & Wellbeing
/
By health reporter Olivia Willis
Posted 11h ago11 hours ago, updated 4h ago4 hours ago

Globally, almost 6.5 billion COVID-19 vaccines have now been administered.(Getty Images: Lisa Maree Williams)
Help keep family & friends informed by sharing this article



Around the world, COVID-19 vaccines are working remarkably well to reduce rates of severe disease and death.
But a growing number of studies suggest their ability to protect people from milder illness and asymptomatic infections is waning with time. But by how much?
It's difficult to "put a hard number on it", says vaccine researcher Kylie Quinn.
"We've moved from these nice, tidy randomised control trials … [to] having to measure it on the run," said Dr Quinn of RMIT University.
For researchers, it's been tricky to tease out how much of what they're seeing is the result of waning immunity, and how much comes down to the Delta variant, the relaxing of restrictions, and the vulnerability of people vaccinated early on.
"I think it's clear that Delta is more of a challenge for these vaccines," Dr Quinn said.
"But now we're starting to get cleaner data sets that show there is an additional challenge of waning immunity."
How much does this matter? And what does it mean as Australia starts to open up?
Let's take a look.
LIVE UPDATES: Read our blog for the latest news on the COVID-19 pandemic

Evidence shows protection against getting COVID wanes with time​

To investigate how well COVID-19 vaccines are working to protect against infection, UK researchers recently assessed more than 350,000 COVID-19 test results taken as part of a large household survey between May and August this year, when the Delta strain was dominating.
Samples were taken at random, regardless of symptoms, to ensure mild and asymptomatic infections were picked up.
The study — which is yet to be peer reviewed — found that two weeks after the second dose, the AstraZeneca vaccine was, on average, 67 per cent effective at preventing COVID-19 infection, and the Pfizer jab was, on average, 80 per cent effective.
The effectiveness of both vaccines reduced over time, though Pfizer's appeared to drop faster. After about 4.5 months, researchers estimated that the effectiveness levels converged.
Similar declines in effectiveness against infection have been reported in Qatar, Israel and the United States, which were among the first countries to roll out COVID-19 vaccines at scale.

Vaccine effectiveness is generally slightly higher in younger compared to older age groups.(Shutterstock: Marc Bruxelle)
Another study, published last week in The Lancet, followed 3.4 million Americans vaccinated with Pfizer.
It found the vaccine's ability to protect against infection fell from 88 per cent to 47 per cent over five months, and that the passage of time — not the Delta variant — was the driving factor behind waning effectiveness.

Read more about the spread of COVID-19 in Australia:​

• Queensland home quarantine trial begins
• No end to lockdown for thousands with compromised immune systems
• Melbourne's south-east is struggling to curb COVID

While immunity declined across all age groups at a similar rate, other research suggests age is an important factor when it comes to protection, and how fast it wanes.
In the UK household study, for example, the effectiveness of the AstraZeneca vaccine two weeks after the second dose was 73 per cent for those under 34, compared to 54 per cent for those 35 and over.

But there's still good news​

The good news is that despite some waning immunity against infection, COVID-19 vaccines remain highly effective at preventing severe disease and death in most people over time.
A preliminary study recently published by the UK's national health agency looked at the duration of protection provided by the COVID-19 vaccines against mild and severe disease.

Coronavirus questions answered​

Breaking down the latest news and research to understand how the world is living through an epidemic, this is the ABC's Coronacast podcast.
Read more
It found that although the effectiveness against symptomatic disease started to wane from about 10 weeks, the vaccines continued to provide high levels of protection against hospital admission and death.

"What it tells us is that beyond 20 weeks, you're still getting 95 per cent protection against severe disease and death with Pfizer … and with AZ, it's about 80 per cent," said Tony Cunningham, an infectious diseases physician and clinical virologist at Sydney's Westmead Institute for Medical Research.

Professor Cunningham is an internationally renowned infectious diseases physician, clinical virologist and scientist.(ABC News: Chris Taylor)
The researchers found the decrease in effectiveness appeared to be more common in adults over 65, and people who are immunocompromised.

"In fact, if you take the vulnerable people out of [the AstraZeneca data], you don't see a drop-off in protection against severe disease," Professor Cunningham said.

The NSW postcodes still at risk at 70pc vaccination rate​

See how vaccination rates and case numbers compare in your area.
Read more

Another study recently published in the New England Journal of Medicine found protection against hospitalisation remained above 90 per cent for six months among fully vaccinated people in Qatar.

Similarly, the US study that followed 3.4 million Pfizer recipients found protection against hospitalisation held strong at 90 per cent for six months, including among older people.

When it comes to the Moderna vaccine, research suggests the jab is even more effective than Pfizer.

"If you look at the thing we most care about — am I going to get very sick and end up in hospital? — all of the studies indicate the COVID-19 vaccines are lasting really well," said David Tscharke, a professor of immunology and infectious diseases at the Australian National University.

"Protection against hospitalisation is fantastic."

Understanding changes in antibody levels​

Another way researchers assess the effectiveness of vaccines is to look for changes in antibody levels in the blood.

Antibodies are essential to helping us fight off infection, and typically surge following vaccination before naturally tapering off.

"We know [antibodies] are somewhat a proxy for effectiveness, but what we don't know [with COVID-19 vaccines] is exactly how that relationship works," Professor Tscharke said.

Generally, the more neutralising antibodies there are circulating in the blood, the less opportunity the virus has to gain a foothold.

But it's not clear what level of antibodies are required to protect against infection or severe disease.

"The amount to keep you out of hospital is probably much less than the amount needed to stop you getting infected," Professor Tscharke said.

"But how far does that level have to fall before you start losing protection? We don't quite know that point yet."

Australia's vaccination rollout​

63.4% fully vaccinated
82.8% at least one dose
70%
80%
20.6mPopulation aged 16+





At our current pace of 1,237,628 second doses a week, we can expect 70 per cent of Australia’s adult population to be fully vaccinated by late October 2021.
Daily vaccinations
First DosesSecond DosesBreakdown unknown

7-day moving average

Feb 23Oct 12200k295.07k
3 MayTotal Doses: 6.54k
Moving average: 46.19k

Total doses include doses given to people aged 12-15 and people who already had two shots of vaccine.
Dates refer to the reporting date (usually the day following vaccination), not the vaccination date.
View the data for your state or territory
While several studies have shown that antibody levels decline in the months following COVID-19 vaccination, Professor Tscharke says that's to be expected, and doesn't necessarily mean they'll keep falling.

"With other vaccines, what tends to happen is that decline then starts slowing down … and then levels off," he said.

It may also be that protection against severe disease has little to do with antibodies, and is instead mediated by the body's memory B cells and T cells, Dr Quinn said.

"We may have these other immune mechanisms at play in our body that are well maintained, that might not be waning as much as antibodies over time," she said.

Cell-mediated immunity tends to be long-lasting and more powerful, but is harder to measure.

"We have some good data that suggests memory B cells are being well maintained … but we don't have that information on a really large scale yet," Dr Quinn said.

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What are the health risks associated with lifting lockdowns? Dr Norman Swan responds

What about breakthrough infections?​

Given that the vaccines aren't 100 per cent effective, we should expect to see some "breakthrough infections" as COVID-19 restrictions begin to lift.

Fortunately, vaccinated people are much less likely to get sick if infected, and very few will require hospitalisation.

That's because if the virus does manage to sneak past the body's first line of defence, it's not long before the immune system — trained by the vaccine — sends in reinforcements to stop it doing serious damage, says Professor Cunningham.

"The virus might get a toehold … but then the immune system comes in and prevents it from spreading further," he said.

A small number of fully vaccinated people with COVID-19 in NSW have died — here's why​

About 11 per cent of the people who have died of COVID-19 during NSW's Delta outbreak have been fully vaccinated — the number doesn't tell the full story.
Read more

Vaccines, however, don't protect everyone equally. The people most at risk of serious illness from a breakthrough infection are the immunocompromised and the elderly.

"In Australia, almost all the [fully vaccinated] people who have died have been over 70, and almost all of them have had comorbidities," Professor Cunningham said.

"You have to bet quite a number of those people are quite severely immunocompromised, as well as aged."

Last week, the Australian Technical Advisory Group on Immunisation recommended a third dose of a COVID-19 vaccine for people who are "severely" immunocompromised.

Professor Tscharke says it's better to think of these shots as third doses in the initial vaccine schedule, rather than as booster vaccines.

Scaling up vaccine coverage​

Australia's vaccination program has picked up pace since local outbreaks in multiple states plunged millions into lockdown.(Getty Images: Jenny Evans)
As for whether the rest of the population will need booster vaccines, most experts agree the more pressing issue is getting as many people inoculated with their first doses as possible.

"[Waning immunity] is a conversation that countries like Israel need to be having, who were early movers and who vaccinated a lot of their population almost a year ago," Professor Tscharke said.

"In Australia, there is only one thing we need to do to protect everyone, and that is get everyone vaccinated."

According to the US Centres for Disease Control, unvaccinated people are still the major drivers of transmission.

Research suggests even if fully vaccinated people do get infected, they are less likely to pass the virus on to others.

"Everyone is focusing on the loss of effectiveness of the vaccine," Professor Tscharke said.

"Really, what we should be talking about is just how effective these vaccines are.

"The only protection [from overwhelming the health system] is getting most people vaccinated, so relatively few people end up in hospital.

"By protecting yourself from severe infection, you're actually protecting the health system as well."

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Casey Briggs looks at national vaccination rates

https://www.abc.net.au/news/health/...EQH4YpKXYRoCMvLdFMQqrCOWh2Bjkkwgelw6w2TTB7X7I