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How to turn your house into a lab ;)
- Thread starter drifter
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Making Methamphetamine at home:
List of chemicals and materials:
Diluted HCl - also called Muriatic acid - can be obtained from hardware stores, in the pool section
NaOH - also called lye
Ethyl Ether - aka Diethyl Ether - Et-0-Et - can be obtained from engine starting fluid, usually from a large supermarket. Look for one that says "high ethyl ether content", such as Prestone
Ephedrine The cottons in todays vicks nasle inhalers dont contain efed or pfed (ephedrin or psuedoephedrin) but there are still lots of easy ways to get good ephed or pfed, pure ephedrin can be extracted out of it's plant matter, from a plant that can be bought at most garden stores. Or you can get pfed from decongestive pills like sudafed. Most people perfer to work with pfed from pills rather then ephed from the plant. The important thing is that you must have pure pfed/ephed as any contaminants will fuck up the molar ratio leaving you with over-reduced shit or under-reduced shit. Or contaminats will jell durring baseifying and gak up your product which will then be very hard to clean. So you want to find a pill that is nearly pure pfed hcl, or as close to pure as you can get. Also check the lable on your pills and see what inactive ingredients they contain. Inactive ingredients are things like binders and flavors. These you dont want and will remove when cleaning your pills. but certain inactive ingredients are harder to remove then others. You dont want pills with a red coating, you dont want pills with alot of cellose in them and you dont want pills with much wax. you also dont want pills that contain povidone. As a rule, if you have a two pills that contain the same amount of pfed hcl then take the smaller sized pill because it obviously has less binders and inactive ingredients, time released pills are usualy harder to work with because they have more binders and tend to gel up durring the a/b stage. Also only buy pills that have pfed hcl as the only active ingredient. You first have to make ephedrine (which is sometimes sold as meth by itself):If you are selling it...I would just make ephedrine and say it's meth.
Distilled water - it's really cheap, so you have no reason to use the nasty stuff from the tap. Do things right.
List of equipment :
A glass eyedropper
Three small glass bottles with lids (approx. 3 oz., but not important)one should be marked at 1.5oz, use tape on the outside to mark it (you might want to label it as ether). One should be clear (and it can't be the marked one).
A Pyrex dish (the meatloaf one is suggested)
A glass quart jar
Sharp scissors
Clean rubber gloves
Coffee filters
A measuring cup
Measuring spoons
Preparing your Lab:
Preparing Ethyl Ether:
WARNING: Ethyl Ether is very flammable and is heavier than air. Do not use ethyl ether near flame or non-sparkless motors. It is also an anaesthetic and can cause respiratory collapse if you inhale too much.
Take the unmarked small bottle and spray starter fluid in it until it looks half-full. Then fill the rest of the way with water, cap the bottle and shake for 5 minutes. Let it sit for a minute or two, and tap the side to try and separate the clear upper layer. Then, draw off the top (ether) layer with the eyedropper, and throw away the lower (water) and cloudy layer. Place the ether in the marked container. Repeat this until you have about 1.5 oz. of ether. Put the cap on it, and put it in the freezer if you can. Rinse the other bottle and let it stand.
Ethyl ether is very pungent. Even a small evaporated amount is quite noticeable.
Ephedrine & or P-Ephedrine: Please discuss this on the neonjoint forum
5. Pour 1/8 teaspoon of the lye crystals into the bottle of ephedrine and agitate. Do this carefully, as the mixture will become hot, and give off hydrogen gas and/or steam. H2 gas is explosive and lighter than air, avoid any flames as usual. Repeat this step until the mixture remains cloudy. This step neutralizes the HCl in the salt, leaving the insoluble free base (l-desoxyephedrine) again. Why do we do this? So that we can get rid of any water-soluble impurities. For 3 oz. bottles, this should take only 3 repetitions or so.
6. Fill the bottle from step 5 up the rest of the way with ethyl ether. Cap the bottle, and agitate for about 8 minutes. It is very important to expose every molecule of the free-base to the ether for as long as possible. This will cause the free base to dissolve into the ether (it -is- soluble in ether).
7. Let the mixture settle. There will be a middle layer that is very thick. Tap the side of the bottle to get this layer as thin as possible. This is why this bottle should be clear.
8. Remove the top (ether) layer with the eyedropper, being careful not to get any of the middle layer in it. Place the removed ether layer into a third bottle.
9. Add to the third bottle enough water to fill it half-way and about 5 drops of muriatic acid. Cap it. Shake the bottle for 2 minutes. When it settles, remove the top layer and throw it away. The free base has now been bonded to the HCl again, forming a water soluble salt. This time, we're getting rid of ether-soluble impurities. Make sure to get rid of all the ether before going to step 11!
10. If there is anything left from step 3, repeat the procedure with it.
11. Evaporate the solution in the Pyrex dish on low heat. You can do this on the stove or nuke it in the microwave (be careful of splashing), but I have found that if you leave it on top of a hot-water heater (like the one that supplies hot water to your house) for about 2-3 days, the remaining crystals will be ephedrine HCl.
If you microwave it, I suggest no more than 5-10s at one time. If it starts "popping", that means you have too little liquid left to microwave. You can put it under a bright (100W) lamp instead. Microwaving can result in uneven heating, anyway.
First Batch: 120mg ephedrine HClEstimated: 300mg (100% of theoretical, disregarding HCl)
Now, Making Methamphetamine out of ephedrine by reducing it with Hydroiodic Acid and Red Phosphorus.
Items needed:
Alot of matchbooks (the kind with the striking pad)
Coffee filters (or filter paper)
Something that measures ml and grams
A flask (a small pot with a lid can be used)
iodine
Hydroiodic Acid (I will tell you how to make this)
Red Phosphorus (I will tell you how to make this)
Lye
*Optional (toluene and HCI gas)
Making Red Phosphorus:
The striking pad on books of matches is about 50% red phosphorus. The determined experimenter could obtain a pile of red phosphorus by scraping off the striking pads of matchbooks with a sharp knife. A typical composition of the striking pad is about 50% red phosphorus, along with about 30% antimony sulfide, and lesser amounts of glue, iron oxide, MnO2, and glass powder. I don't think these contaminants will seriously interfere with the reaction. Naturally, it is a tedious process to get large amounts of red phosphorus by scraping the striking pads off matchbooks, but who cares?
Making Hydroiodic Acid:
This is made by mixing iodine and red phosphorus. When making hydroiodic acid from iodine and red phosphorus, the acid is prepared first, and allowed to come to complete reaction for 20 minutes before adding the ephedrine to it. The way around the roadblock here is to just boil off some more of the water from the ephedrine extract, and make the acid mixture in fresh pure water. Since the production of HI from iodine and red phosphorus gives off a good deal of heat, it is wise to chill the mixture in ice, and slowly add the iodine crystals to the red phosphorus-water mixture.
Now, Making Methamphetamine:
To do the reaction, a 1000 ml round bottom flask is filled with 150 grams of ephedrine. Also added to the flask are 40 grams of red phosphorus and 340 ml of 47% hydroiodic acid. This same acid and red phosphorus mixture can be prepared from adding 150 grams of iodine crystals to 150 grams of red phosphorus in 300 ml of water. This should produce the strong hydroiodic acid solution needed. Exactly how strong the acid needs to be, I can't say . With the ingredients mixed together in the flask, a condenser is attached to the flask, and the mixture is boiled for one day. This length of time is needed for best yields and highest octane numbers on the product. While it is cooking, the mixture is quite red and messy looking from the red phosphorus floating around in it.When one day of boiling under reflux is up, the flask is allowed to cool, then it is diluted with an equal volume of water. Next, the red phosphorus is filtered out. A series of doubled up coffee filters will work to get out all the red phosphorus, but real filter paper is better. The filtered solution should look a golden color. A red color may indicate that all the red phosphorus is not yet out. If so, it is filtered again. The filtered-out phosphorus can be saved for use in the next batch. If filtering does not remove the red color, there may be iodine floating around the solution. It can be removed by adding a few dashes of sodium bisulfate or sodium thiosulfate.The next step in processing the batch is to neutralize the acid. A strong lye solution is mixed up and added to the batch while shaking until the batch is strongly basic. This brings the meth out as liquid free base floating on top of the water. The strongly basic solution is shaken vigorously to ensure that all the meth has been converted to the free base. You now can sell or use the free base for injection use or with free base meth now obtained, the next step you can do is to form the crystalline hydrochloride salt of meth. To do this, a few hundred mls of toluene is added to the batch, and the meth free base extracted out as usual. If the chemist's cooking has been careful, the color of the toluene extract will be clear to pale yellow. If this is the case, the product is sufficiently pure to make nice white crystals just by bubbling dry HCl gas through the toluene extract. If the toluene extract is darker colored, a distillation is called for to get pure meth free base. The yield of pure methamphetamine hydrochloride should be from 100 to 110 grams.
List of chemicals and materials:
Diluted HCl - also called Muriatic acid - can be obtained from hardware stores, in the pool section
NaOH - also called lye
Ethyl Ether - aka Diethyl Ether - Et-0-Et - can be obtained from engine starting fluid, usually from a large supermarket. Look for one that says "high ethyl ether content", such as Prestone
Ephedrine The cottons in todays vicks nasle inhalers dont contain efed or pfed (ephedrin or psuedoephedrin) but there are still lots of easy ways to get good ephed or pfed, pure ephedrin can be extracted out of it's plant matter, from a plant that can be bought at most garden stores. Or you can get pfed from decongestive pills like sudafed. Most people perfer to work with pfed from pills rather then ephed from the plant. The important thing is that you must have pure pfed/ephed as any contaminants will fuck up the molar ratio leaving you with over-reduced shit or under-reduced shit. Or contaminats will jell durring baseifying and gak up your product which will then be very hard to clean. So you want to find a pill that is nearly pure pfed hcl, or as close to pure as you can get. Also check the lable on your pills and see what inactive ingredients they contain. Inactive ingredients are things like binders and flavors. These you dont want and will remove when cleaning your pills. but certain inactive ingredients are harder to remove then others. You dont want pills with a red coating, you dont want pills with alot of cellose in them and you dont want pills with much wax. you also dont want pills that contain povidone. As a rule, if you have a two pills that contain the same amount of pfed hcl then take the smaller sized pill because it obviously has less binders and inactive ingredients, time released pills are usualy harder to work with because they have more binders and tend to gel up durring the a/b stage. Also only buy pills that have pfed hcl as the only active ingredient. You first have to make ephedrine (which is sometimes sold as meth by itself):If you are selling it...I would just make ephedrine and say it's meth.
Distilled water - it's really cheap, so you have no reason to use the nasty stuff from the tap. Do things right.
List of equipment :
A glass eyedropper
Three small glass bottles with lids (approx. 3 oz., but not important)one should be marked at 1.5oz, use tape on the outside to mark it (you might want to label it as ether). One should be clear (and it can't be the marked one).
A Pyrex dish (the meatloaf one is suggested)
A glass quart jar
Sharp scissors
Clean rubber gloves
Coffee filters
A measuring cup
Measuring spoons
Preparing your Lab:
Preparing Ethyl Ether:
WARNING: Ethyl Ether is very flammable and is heavier than air. Do not use ethyl ether near flame or non-sparkless motors. It is also an anaesthetic and can cause respiratory collapse if you inhale too much.
Take the unmarked small bottle and spray starter fluid in it until it looks half-full. Then fill the rest of the way with water, cap the bottle and shake for 5 minutes. Let it sit for a minute or two, and tap the side to try and separate the clear upper layer. Then, draw off the top (ether) layer with the eyedropper, and throw away the lower (water) and cloudy layer. Place the ether in the marked container. Repeat this until you have about 1.5 oz. of ether. Put the cap on it, and put it in the freezer if you can. Rinse the other bottle and let it stand.
Ethyl ether is very pungent. Even a small evaporated amount is quite noticeable.
Ephedrine & or P-Ephedrine: Please discuss this on the neonjoint forum
5. Pour 1/8 teaspoon of the lye crystals into the bottle of ephedrine and agitate. Do this carefully, as the mixture will become hot, and give off hydrogen gas and/or steam. H2 gas is explosive and lighter than air, avoid any flames as usual. Repeat this step until the mixture remains cloudy. This step neutralizes the HCl in the salt, leaving the insoluble free base (l-desoxyephedrine) again. Why do we do this? So that we can get rid of any water-soluble impurities. For 3 oz. bottles, this should take only 3 repetitions or so.
6. Fill the bottle from step 5 up the rest of the way with ethyl ether. Cap the bottle, and agitate for about 8 minutes. It is very important to expose every molecule of the free-base to the ether for as long as possible. This will cause the free base to dissolve into the ether (it -is- soluble in ether).
7. Let the mixture settle. There will be a middle layer that is very thick. Tap the side of the bottle to get this layer as thin as possible. This is why this bottle should be clear.
8. Remove the top (ether) layer with the eyedropper, being careful not to get any of the middle layer in it. Place the removed ether layer into a third bottle.
9. Add to the third bottle enough water to fill it half-way and about 5 drops of muriatic acid. Cap it. Shake the bottle for 2 minutes. When it settles, remove the top layer and throw it away. The free base has now been bonded to the HCl again, forming a water soluble salt. This time, we're getting rid of ether-soluble impurities. Make sure to get rid of all the ether before going to step 11!
10. If there is anything left from step 3, repeat the procedure with it.
11. Evaporate the solution in the Pyrex dish on low heat. You can do this on the stove or nuke it in the microwave (be careful of splashing), but I have found that if you leave it on top of a hot-water heater (like the one that supplies hot water to your house) for about 2-3 days, the remaining crystals will be ephedrine HCl.
If you microwave it, I suggest no more than 5-10s at one time. If it starts "popping", that means you have too little liquid left to microwave. You can put it under a bright (100W) lamp instead. Microwaving can result in uneven heating, anyway.
First Batch: 120mg ephedrine HClEstimated: 300mg (100% of theoretical, disregarding HCl)
Now, Making Methamphetamine out of ephedrine by reducing it with Hydroiodic Acid and Red Phosphorus.
Items needed:
Alot of matchbooks (the kind with the striking pad)
Coffee filters (or filter paper)
Something that measures ml and grams
A flask (a small pot with a lid can be used)
iodine
Hydroiodic Acid (I will tell you how to make this)
Red Phosphorus (I will tell you how to make this)
Lye
*Optional (toluene and HCI gas)
Making Red Phosphorus:
The striking pad on books of matches is about 50% red phosphorus. The determined experimenter could obtain a pile of red phosphorus by scraping off the striking pads of matchbooks with a sharp knife. A typical composition of the striking pad is about 50% red phosphorus, along with about 30% antimony sulfide, and lesser amounts of glue, iron oxide, MnO2, and glass powder. I don't think these contaminants will seriously interfere with the reaction. Naturally, it is a tedious process to get large amounts of red phosphorus by scraping the striking pads off matchbooks, but who cares?
Making Hydroiodic Acid:
This is made by mixing iodine and red phosphorus. When making hydroiodic acid from iodine and red phosphorus, the acid is prepared first, and allowed to come to complete reaction for 20 minutes before adding the ephedrine to it. The way around the roadblock here is to just boil off some more of the water from the ephedrine extract, and make the acid mixture in fresh pure water. Since the production of HI from iodine and red phosphorus gives off a good deal of heat, it is wise to chill the mixture in ice, and slowly add the iodine crystals to the red phosphorus-water mixture.
Now, Making Methamphetamine:
To do the reaction, a 1000 ml round bottom flask is filled with 150 grams of ephedrine. Also added to the flask are 40 grams of red phosphorus and 340 ml of 47% hydroiodic acid. This same acid and red phosphorus mixture can be prepared from adding 150 grams of iodine crystals to 150 grams of red phosphorus in 300 ml of water. This should produce the strong hydroiodic acid solution needed. Exactly how strong the acid needs to be, I can't say . With the ingredients mixed together in the flask, a condenser is attached to the flask, and the mixture is boiled for one day. This length of time is needed for best yields and highest octane numbers on the product. While it is cooking, the mixture is quite red and messy looking from the red phosphorus floating around in it.When one day of boiling under reflux is up, the flask is allowed to cool, then it is diluted with an equal volume of water. Next, the red phosphorus is filtered out. A series of doubled up coffee filters will work to get out all the red phosphorus, but real filter paper is better. The filtered solution should look a golden color. A red color may indicate that all the red phosphorus is not yet out. If so, it is filtered again. The filtered-out phosphorus can be saved for use in the next batch. If filtering does not remove the red color, there may be iodine floating around the solution. It can be removed by adding a few dashes of sodium bisulfate or sodium thiosulfate.The next step in processing the batch is to neutralize the acid. A strong lye solution is mixed up and added to the batch while shaking until the batch is strongly basic. This brings the meth out as liquid free base floating on top of the water. The strongly basic solution is shaken vigorously to ensure that all the meth has been converted to the free base. You now can sell or use the free base for injection use or with free base meth now obtained, the next step you can do is to form the crystalline hydrochloride salt of meth. To do this, a few hundred mls of toluene is added to the batch, and the meth free base extracted out as usual. If the chemist's cooking has been careful, the color of the toluene extract will be clear to pale yellow. If this is the case, the product is sufficiently pure to make nice white crystals just by bubbling dry HCl gas through the toluene extract. If the toluene extract is darker colored, a distillation is called for to get pure meth free base. The yield of pure methamphetamine hydrochloride should be from 100 to 110 grams.
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actually for the fun of it i read through post 6.
step 5 can dissolve the base in water first b4 adding. this way u can reduce the heat prevent unwanted side reaction
side 9 to 11 do not think will works very well. as u are using the same dilute acid to force secondary amine to be protonated to be soluble. personally i think wun work unless u have a way to concentrate the acid. i suspect the person who post this is talking cock never do this himself personally.
preparation of HI is insane .... cooking red phosphurs!??!!?? starting to understand why those ang mo blow themselves up
let me go find out how the acadamic lab do it. i personally even though trained will try to avoid that kind of dangerous step if possible in daily life
step 5 can dissolve the base in water first b4 adding. this way u can reduce the heat prevent unwanted side reaction
side 9 to 11 do not think will works very well. as u are using the same dilute acid to force secondary amine to be protonated to be soluble. personally i think wun work unless u have a way to concentrate the acid. i suspect the person who post this is talking cock never do this himself personally.
preparation of HI is insane .... cooking red phosphurs!??!!?? starting to understand why those ang mo blow themselves up
let me go find out how the acadamic lab do it. i personally even though trained will try to avoid that kind of dangerous step if possible in daily life
Last edited:
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this is the safer route to me using the same starting material with way less risk involved. Assume u have ephedrine in hand. hydrogen gas mention can be replaced with hydrazine, i personally dun like to work with gas as well. the only challenge here is getting socl2 (very hard to get this on hand) and palladium (actually not too hard). rest of it ... somehow u can find a way LOL
J Forensic Sci, May 2010, Vol. 55, No. 3, 605-615 <---this actually provide a very good review and analysis of the street method and its byproducts and what is the best way to make this.
Synthesis of Chloroephedrine ⁄ Chloropseudoephedrine—A
solution of chloroform and thionyl chloride was chilled in an icebath.
To this was slowly added pseudoephedrine (or ephedrine)
hydrochloride, and the mixture was stirred for several hours.
Diethyl ether was then added resulting in precipitation of chloroephedrine
(or chlorospeudoephedrine) hydrochloride. The product
was washed with ether ⁄ chloroform and dried yielding chloroephedrine
hydrochloride (13) (Fig. 1).
Synthesis of Methylamphetamine via ‘‘Emde’’ Route
Sodium acetate anhydrous and water were added to a flask and the mixture
was made neutral with acetic acid. Palladium on barium sulfate
and chloroephedrine hydrochloride were then added. The flask was
attached to a Parr 3911 hydrogenation apparatus (Moline, Illinois).
The air was removed from the flask by vacuum pump and flushed
with hydrogen several times and then charged with hydrogen to
30 psi. The flask was mechanically shaken until uptake of hydrogen
ceased. The catalyst was filtered off and washed with water.
The combined reaction mixture and aqueous washings were
basified with dilute sodium hydroxide solution and the methylamphetamine
base was extracted with dichloromethane. The dichloromethane
was removed using a rotary evaporator leaving
methylamphetamine base as an oil. The oil was converted to the
hydrochloride salt by dissolving it in cooled isopropanol and acidifying
with concentrated hydrochloric acid. Diethyl ether was added
resulting in precipitation of a crystalline material. The crystals were
filtered, washed with a mixture of isopropanol and diethyl ether,
and dried yielding methylamphetamine hydrochloride (13) (Fig. 1).
A total of nineteen ‘Emde’ preparations of (2S)-methylamphetamine
were carried out. Fourteen were based on (1S,2S)-(+)-
pseudoephedrine, three were based on (1R,2S)-())-ephedrine, and
two were based on a mixture of (1R,2S)-())-ephedrine and (1S,2S)-
(+)-pseudoephedrine.
J Forensic Sci, May 2010, Vol. 55, No. 3, 605-615 <---this actually provide a very good review and analysis of the street method and its byproducts and what is the best way to make this.
Synthesis of Chloroephedrine ⁄ Chloropseudoephedrine—A
solution of chloroform and thionyl chloride was chilled in an icebath.
To this was slowly added pseudoephedrine (or ephedrine)
hydrochloride, and the mixture was stirred for several hours.
Diethyl ether was then added resulting in precipitation of chloroephedrine
(or chlorospeudoephedrine) hydrochloride. The product
was washed with ether ⁄ chloroform and dried yielding chloroephedrine
hydrochloride (13) (Fig. 1).
Synthesis of Methylamphetamine via ‘‘Emde’’ Route
Sodium acetate anhydrous and water were added to a flask and the mixture
was made neutral with acetic acid. Palladium on barium sulfate
and chloroephedrine hydrochloride were then added. The flask was
attached to a Parr 3911 hydrogenation apparatus (Moline, Illinois).
The air was removed from the flask by vacuum pump and flushed
with hydrogen several times and then charged with hydrogen to
30 psi. The flask was mechanically shaken until uptake of hydrogen
ceased. The catalyst was filtered off and washed with water.
The combined reaction mixture and aqueous washings were
basified with dilute sodium hydroxide solution and the methylamphetamine
base was extracted with dichloromethane. The dichloromethane
was removed using a rotary evaporator leaving
methylamphetamine base as an oil. The oil was converted to the
hydrochloride salt by dissolving it in cooled isopropanol and acidifying
with concentrated hydrochloric acid. Diethyl ether was added
resulting in precipitation of a crystalline material. The crystals were
filtered, washed with a mixture of isopropanol and diethyl ether,
and dried yielding methylamphetamine hydrochloride (13) (Fig. 1).
A total of nineteen ‘Emde’ preparations of (2S)-methylamphetamine
were carried out. Fourteen were based on (1S,2S)-(+)-
pseudoephedrine, three were based on (1R,2S)-())-ephedrine, and
two were based on a mixture of (1R,2S)-())-ephedrine and (1S,2S)-
(+)-pseudoephedrine.
Last edited:
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SamLeong,
Drugs are evil so kindly deposit this filthy thread into the rubbish heap.
Drugs are evil so kindly deposit this filthy thread into the rubbish heap.
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- Joined
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- Messages
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How to make cocaine at home
Just because I was curious as to what chemicals are involved in the synthesis I decided to find a complete synthesis online so here's one for you. Theoretically all of these chemicals are easily attainable, it's just getting a few kilos of coca leaves to make it worthwhile that's the problem. If you could do that you could easily make cocaine in your house. Here's the complete synthesis from coca leaves to coca paste to cocaine sulfate to cocaine HCL...
--Step 1
The coca leaves are put in an above-ground container or in a plastic lined
pit. An alkaline material (sodium carbonate) and water are added to the
leaves. Here the alkaline material enables the cocaine alkaloid present in
the leaf to be extracted into kerosene.
--Step 2
A water immiscible solvent (kerosene) is added to water, solution, and
leaves. The mixture is then agitated. Usually this is accomplished by having
several people stomp on the leaves. The solvent acts to extract water
insoluble cocaine alkaloids from the alkaline solution.
--Step 3
Cocaine alkaloids and kerosene separate from water and leaves. The water and
leaves are then drained off.
--Step 4
Cocaine alkaloids are extracted from the kerosene into a dilute acid
solution. Alkaline material (sodium carbonate) is added to the remaining
solution which causes a precipitate to form . The acid and the water are
drained off and the precipitate is filtered and dried to produce coca paste,
a chunky, off-white to light brown, putty-like
substance.
Coca Paste to Cocaine Base
The processing of coca paste into cocaine base is more complicated than paste
production, requiring more sophisticated equipment and added skills. Cocaine
base can be processed at the paste facility, but base laboratories may be
located away from the cultivation zones. Usually the base laboratories are
located near rivers or have a clandestine airstrip located in the vicinity to
facilitate both the movement of coca paste into the base laboratory, but also
the movement of cocaine base to cocaine HCl laboratories.
As with the paste recipes, the base recipes have many versions. This one is
one of the more common and a continuation of the paste recipe.
--Step 1
The coca paste is added to sulfuric acid or hydrochloric acid and water. The
paste is dissolved into the acid solution.
--Step 2
Potassium permanganate is combined with water. This mixture is added to the
coca paste and acid solution. Potassium permanganate is used in this step to
extract other alkaloids and material that is undesired in the final product.
In particular, potassium permanganate is used to break down the alkaloid
ciscinnamoylcocaine found in large concentrations in E. novogranatense
varieties. If the coca paste has a high concentration of this alkaloid and
potassium permanganate is not used, then crystallization of cocaine HCl will
be very difficult.
--Step 3
This mixture is allowed to stand for about six hours.
--Step 4
The solution is filtered and the precipitate is discarded. Ammonia water is
added to the filtered solution and another precipitate is formed.
--Step 5
The liquid is drained from the solution and the remaining precipitate is
usually dried with heating lamps. The resulting powder is cocaine base.
It is common in Colombia to skip the base stage of cocaine processing and go
right from coca paste to cocaine HCl. This can be accomplished by eliminating
the last part of step number four in coca paste processing and skipping to
step number two of the cocaine base phase where the coca paste is added to
the potassium permanganate solution.
Cocaine Base to Cocaine Hydrochloride (HCl)
The final stage of cocaine processing requires even more skill and equipment,
and is much more dangerous than the previously mentioned steps. Unlike paste
and base processing, cocaine HCl processing calls for expensive chemicals
that are harder to find and often not manufactured in the processing country.
The HCl laboratory usually consists of several buildings including
dormitories, eating facilities, an office, storage facilities, and the
laboratory itself. Also usually found at HCl laboratories are communications
operations, generators, filtering and drying equipment, and, more recently,
chemical recycling facilities. The HCl laboratory will sometimes have direct
access to an airstrip.
The following recipe is a continuation of the above two. At this point the
methods of processing vary only slightly.
--Step 1
Acetone or ether is added to dissolve the cocaine base and the solution is
filtered to remove undesired material.
--Step 2
Hydrochloric acid diluted in acetone or ether is added to the cocaine
solution. The addition of the hydrochloric acid causes the cocaine to
precipitate (crystallize) out of the solution as cocaine hydrochloride.
--Step 3
The remaining acetone/ether solvent can be discarded or reused.
--Step 4
Cocaine HCl is dried under heat lamps, laid out to dry with the aid of fans,
or dried in microwave ovens.
http://www.druglibrary.org/schaffer/govpubs/cocccp.htm
Here's a quick list from that of what's needed chemically...
- Sodium Carbonate (known as Soda Ash and used as an everyday water softener, easily attainable)
- Water (obviously attainable)
- Kerosene (same as water)
- Sulfuric or Hydrochloric Acid (a little harder to get but you can get it online if you look around)
- Potassium Permanganate (only needed if making cocaine base, which can be skipped but to attain it you can use it for a ton of stuff... http://en.wikipedia.org/wiki/Potassium_permanganate)
- Ammonia (only needed if making cocaine base, easily attainable)
- Acetone or Ether (Ether is just car starting fluid and acetone is easy to get online)
Based off of the ingredients list if you could get the leaves you could easily make your own cocaine, granted you had the chemistry knowledge and could figure out how much of each chemical to use.
Just because I was curious as to what chemicals are involved in the synthesis I decided to find a complete synthesis online so here's one for you. Theoretically all of these chemicals are easily attainable, it's just getting a few kilos of coca leaves to make it worthwhile that's the problem. If you could do that you could easily make cocaine in your house. Here's the complete synthesis from coca leaves to coca paste to cocaine sulfate to cocaine HCL...
--Step 1
The coca leaves are put in an above-ground container or in a plastic lined
pit. An alkaline material (sodium carbonate) and water are added to the
leaves. Here the alkaline material enables the cocaine alkaloid present in
the leaf to be extracted into kerosene.
--Step 2
A water immiscible solvent (kerosene) is added to water, solution, and
leaves. The mixture is then agitated. Usually this is accomplished by having
several people stomp on the leaves. The solvent acts to extract water
insoluble cocaine alkaloids from the alkaline solution.
--Step 3
Cocaine alkaloids and kerosene separate from water and leaves. The water and
leaves are then drained off.
--Step 4
Cocaine alkaloids are extracted from the kerosene into a dilute acid
solution. Alkaline material (sodium carbonate) is added to the remaining
solution which causes a precipitate to form . The acid and the water are
drained off and the precipitate is filtered and dried to produce coca paste,
a chunky, off-white to light brown, putty-like
substance.
Coca Paste to Cocaine Base
The processing of coca paste into cocaine base is more complicated than paste
production, requiring more sophisticated equipment and added skills. Cocaine
base can be processed at the paste facility, but base laboratories may be
located away from the cultivation zones. Usually the base laboratories are
located near rivers or have a clandestine airstrip located in the vicinity to
facilitate both the movement of coca paste into the base laboratory, but also
the movement of cocaine base to cocaine HCl laboratories.
As with the paste recipes, the base recipes have many versions. This one is
one of the more common and a continuation of the paste recipe.
--Step 1
The coca paste is added to sulfuric acid or hydrochloric acid and water. The
paste is dissolved into the acid solution.
--Step 2
Potassium permanganate is combined with water. This mixture is added to the
coca paste and acid solution. Potassium permanganate is used in this step to
extract other alkaloids and material that is undesired in the final product.
In particular, potassium permanganate is used to break down the alkaloid
ciscinnamoylcocaine found in large concentrations in E. novogranatense
varieties. If the coca paste has a high concentration of this alkaloid and
potassium permanganate is not used, then crystallization of cocaine HCl will
be very difficult.
--Step 3
This mixture is allowed to stand for about six hours.
--Step 4
The solution is filtered and the precipitate is discarded. Ammonia water is
added to the filtered solution and another precipitate is formed.
--Step 5
The liquid is drained from the solution and the remaining precipitate is
usually dried with heating lamps. The resulting powder is cocaine base.
It is common in Colombia to skip the base stage of cocaine processing and go
right from coca paste to cocaine HCl. This can be accomplished by eliminating
the last part of step number four in coca paste processing and skipping to
step number two of the cocaine base phase where the coca paste is added to
the potassium permanganate solution.
Cocaine Base to Cocaine Hydrochloride (HCl)
The final stage of cocaine processing requires even more skill and equipment,
and is much more dangerous than the previously mentioned steps. Unlike paste
and base processing, cocaine HCl processing calls for expensive chemicals
that are harder to find and often not manufactured in the processing country.
The HCl laboratory usually consists of several buildings including
dormitories, eating facilities, an office, storage facilities, and the
laboratory itself. Also usually found at HCl laboratories are communications
operations, generators, filtering and drying equipment, and, more recently,
chemical recycling facilities. The HCl laboratory will sometimes have direct
access to an airstrip.
The following recipe is a continuation of the above two. At this point the
methods of processing vary only slightly.
--Step 1
Acetone or ether is added to dissolve the cocaine base and the solution is
filtered to remove undesired material.
--Step 2
Hydrochloric acid diluted in acetone or ether is added to the cocaine
solution. The addition of the hydrochloric acid causes the cocaine to
precipitate (crystallize) out of the solution as cocaine hydrochloride.
--Step 3
The remaining acetone/ether solvent can be discarded or reused.
--Step 4
Cocaine HCl is dried under heat lamps, laid out to dry with the aid of fans,
or dried in microwave ovens.
http://www.druglibrary.org/schaffer/govpubs/cocccp.htm
Here's a quick list from that of what's needed chemically...
- Sodium Carbonate (known as Soda Ash and used as an everyday water softener, easily attainable)
- Water (obviously attainable)
- Kerosene (same as water)
- Sulfuric or Hydrochloric Acid (a little harder to get but you can get it online if you look around)
- Potassium Permanganate (only needed if making cocaine base, which can be skipped but to attain it you can use it for a ton of stuff... http://en.wikipedia.org/wiki/Potassium_permanganate)
- Ammonia (only needed if making cocaine base, easily attainable)
- Acetone or Ether (Ether is just car starting fluid and acetone is easy to get online)
Based off of the ingredients list if you could get the leaves you could easily make your own cocaine, granted you had the chemistry knowledge and could figure out how much of each chemical to use.
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How bout breaking up a bunch of panadols and telling your mates you got cocaine?
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How bout breaking up a bunch of panadols and telling your mates you got cocaine?
im no science genius but ive been researching this today and infact you CAN make cocaine at home. i found the whole synthesis online. the awesome part about this is you need no coca leaves for it. the chemical found in coca leaves is ecgonine or methylecgonine i do believe (it says in the synthesis) and you then mess around with than a bit and eventually end up with an end product of pretty much pure cocaine.. im on the fence right now about wether i should try this. it doesnt seem too complicated but i have done many extractions and conversions of druugs and this one seems pretty procise and detailed. wouldnt recommend it to anyone with an IQ under 100..
.anyways heres the whole synthesis. Welcome to the complete guide of how to make cocaine. If you do
everything right you are going to be king of the world, either in your
own world or in the real world. Please read the disclaimer at the end of
this text.
Now, let's get to action!
The basic formula for cocaine starts by purchasing or making tropinine,
converting the tropinone into 2-carbomethoxytropinone (also known as
methyl-tropan-3-one-2-carboxylate), reducing this to ecgonine,
and changing that to cocaine.
Succindialdehyde. This can be purchased, too. 23.2 g of succinaldoxime
powder in 410 ml of 1 N sulfuric acid and add dropwise with stirring at
0* a solution of 27.6 g of sodium nitrite in 250 ml of water over
3 hours. After the addition, stir and let the mixture rise to room temp
for about 2 hours, taking care not to let outside air into the reaction.
Stir in 5 g of Ba carbonate and filter. Extract the filtrate with ether
and dry, evaporate in vacuo to get the succindialdehyde. This was t
aken from JOC, 22, 1390 (1957). To make succinaldoxime, see JOC, 21,
644 (1956).
Complete Synthesis of Succindialdehyde. JACS, 68, 1608 (1946). In a 2 liter
3 necked flask equipped with a stirrer, reflux condenser, and an addition
funnel, is mixed 1 liter of ethanol, 67 g of freshly distilled pyrrole, and
141 g of hydroxylamine hydrochloride. Heat to reflux until dissolved, add
106 g of anhydrous sodium carbonate in small portions as fast as reaction
will allow. Reflux for 24 hours and filter the mixture. Evaporate the
filtrate to dryness under vacuo. Take up the residue in the minimum amount
of boiling water, decolorize with carbon, filter and allow to recrystallize
in refrigerator. Filter to get product and concentrate to get additional
crop. Yield of succinaldoxime powder is a little over 40 g, mp is 171-172*.
5.8 g of the above powder is placed in a beaker of 250 ml capacity and
54 ml of 10% sulfuric acid is added. Cool to 0* and add in small portions
of 7 g of sodium nitrite (if you add the nitrite too fast, nitrogen dioxide
fumes will evolve). After the dioxime is completely dissolved, allow the
solution to warm to 20* and effervescence to go to completion. Neutralize
the yellow solution to litmus by adding small portions of barium carbonate.
Filter off the barium sulfate that precipitates. The filtrate is 90% pure
succindialdehyde and is not purified further for the reaction to create
tropinone. Do this procedure 3 more times to get the proper amount for the
next step, or multiply the amounts given by four and proceed as described
above.
Take the total amount of succinaldehyde (obtained from 4 of the above
syntheses combined) and without further treatment or purification (this had
better be 15.5 g of succindialdehyde) put into an Erlenmeyer flask of
4-5 liters capacity. Add 21.6 g of methylamine hydrochloride, 46.7 g of
acetonedicarboxylic acid, and enough water to make a total volume of 2
liters. Adjust the pH to 8-10 by slowly adding a saturated solution of
disodium phosphate. The condensate of this reaction (allow to set for
about 6 days) is extracted with ether, the ethereal solution is dried
over sodium sulphate and distilled, the product coming over at 113* at
25 mm of pressure is collected. Upon cooling, 14 g of tropinone
crystallizes in the pure state.
2-Carbomethoxytropinone. A mixture of 1.35 g of sodium methoxide
(this is sodium in a minimum amount of methanol), 3.5 g of tropinone,
4 ml of dimethylcarbonate and 10 ml of toluene is refluxed for 30 min.
Cool to 0* and add 15 ml of water that contains 2.5 g of ammonium chloride.
Extract the solution after shaking with with four 50 ml portions of
chloroform, dry, evaporate the chloroform in vacuo. Dissolve the oil
residue in 100 ml of ether, wash twice with a mixture of 6 ml of
saturated potassium carbonate and three ml of 3 N KOH. Dry and evaporate
in vacuo to recover the unreacted tropinone. Take up the oil in a solution
of aqueous ammonium chloride and extract with chloroform, dry, and evaporate
in vacuo to get an oil. The oil is dissolved in hot acetone, cool, and
scratch inside of flask with glass rod to precipitate
2-carbomethoxytropinone. Recrystallize 16 g of this product in 30 ml of hot
methyl acetate and add 4 ml of cold water and 4 ml of acetone. Put in
freezer for 2 1/2 to 3 hours. Filter and wash the precipitate with cold
methyl acetate to get pure product.
Methylecgonine. 0.4 mole of tropinone is suspended in 80 ml of ethanol
in a Parr hydrogenation flask (or something that can take 100 psi and not
react with the reaction, like stainless steel or glass). 10 g of Raney
Nickle is added with good agitation (stirring or shaking) followed by
2-3 ml of 20% NaOH solution. Seal vessel, introduce 50 psi of hydrogen
atmosphere (after flushing vessel with hydrogen) and heat to 40-50*.
After no more uptake of hydrogen (pressure gauge will hold steady after
dropping to its lowest point) bleed off pressure and filter the nickle off,
rinse out bottle with chloroform and use this rinse to rinse off the nickle
while still on the filter paper. Make the filtrate basic with KOH after
cooling to 10*. Extract with chloroform dry, and evaporate the chloroform
in vacuo to get an oil. Mix the oil plus any precipitate with an equal
volume of dry ether and filter. Add more dry ether to the filtrate until
no more precipitate forms, filter and add to the rest of the precipetate.
Recrystallize from isopropanol to get pure methylecgonine. Test for activity.
If active, skip down to the step for cocaine. If not active, proceed as
follows. Stir with activated carbon for 30 min, filter, evaporate in vacuo,
dissolve the brown liquid in methanol, and neutralize with 10% HCl acid in
dry ether. Evaporate the ether until the two layers disappear, and allow to
stand for 2 hours at 0* to precipitate the title product. There are many
ways to reduce 2-carbomethoxytropinone to methylecgonine. I chose to design
a Raney Nickle reduction because it is cheap and not as suspicious as LAH
and it is much easier than zinc or sodium amalgams.
Cocaine. 4.15 g of methylecgonine and 5.7 g of benzoic anhydride in 150 ml
of dry benzene are gently refluxed for 4 hours taking precaution against
H20 (the 2 should be on a lower level) in the air (drying tube). Cool in an
ice bath, acidify carefully with hydrochloric acid, dry, and evaporate in a
vacuum to get a red oil which is treated with a little portion of isopropanol
to precipitate cocaine.
As you can see, this is quite a chore. The coca leaves give ecgonine, which
as you can see, is only a jump away from cocaine. If you can get egconine,
then dissolve 8 1/2 g of it in 100 ml of ethanol and pass (bubble) dry HC1
gas through this solution for 30 min. Let cool to room temp and let stand
for another 1 1/2 hours. Gently reflux for 30 min and evaporate in vacuo.
Basify the residue oil with NaOH and filter to get 8.4 g of methylecgonine,
which is converted to cocaine as in the cocain step above.
Below is given a somewhat easier method of producing tropinone by the
general methods of Willstatter, who was instrumental in the first synthetic
production of cocaine and several other alkaloids. After reviewing this
method, I found it to be simpler than the above in many respects.
Tropinone. 10 g of pyrrolidinediethyl diacetate are heated with 10 g of
cymene and 2 g of sodium powder, the reaction taking place at about 160*.
During the reaction (which is complete in about 10 min) the temp should not
exceed 172*. The resulting reaction product in dissolved in water, then
saturated with potassium carbonate, and the oil, which separates, is boiled
with dilute sulfuric acid. 2.9 g of tropinone picrate forms and is filtered.
Here are two more formulas devised by Willstatter that produce tropinone
from tropine. Take note of the yield differences.
Tropinone. To a solution of 25 g tropine, dissolved in 10 times its weight
of 20% sulfuric acid are added 25 g of a 4% solution of potassiumpermanganate
in 2 or 3 g portions over 45 min while keeping the temp at 10-12*. The
addition of permanganate will cause heat (keep the temp 10-12*) and
precipitation of manganese dioxide. The reaction mixture is complete in
1 hour. A large excess of NaOH is added and the reaction is steam distilled
until 1 liter of distillate has been collected. The tropinone is
isolated as the dibenzal compound by mixing the distillate with 40 g of
benzaldehyde in 500 cc of alcohol and 40 of 10% sodium hydroxide solution.
Let stand several days to get dibenzaltropinone as yellow needles.
Yield: 15.5 g, 28%. Recrystallize from ethanol to purify.
Tropinone. A solution of 12 g of chromic acid in the same amount of
water (12 g) and 60 g of glacial acetic acid is added dropwise with stirring
over a period of 4 hours to a solution of 25 g of tropine in 500 cc of
glacial acetic acid that has been warmed to 60-70* and is maintained at this
temp during the addition. Heat the mixture for a short time on a steam bath
until all the chromic acid has disappeared, cool and make strongly alkaline
with NaOH. Extract with six 500 cc portions of ether and evaporate the ether
in vacuo to get an oil that crystallizes readily. Purify by convering to the
picrate or fractionally distill, collecting the fraction at 224-225* at
714 mm vacuo.
The tropinones can be used in the above formula (or in a formula that you
have found elsewhere) to be converted to cocaine. Remember to recrystallize
the 2-carbomethoxytropinone before converting to methylecgonine.
PS : This thread is spread for informational purpose only. I am not responsible
if someone is injured while using this information. After all, information
wants to be free.
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your last thread is made by a trained professional i suspect from pharma company. his style of recrystallisation is commonly used in such company and the scale of the reaction is ridiculously large. it very elegant, not possible to be made by any tom dick wanna be chemist. but i would not recommend the 2nd route that you have posted. personally i have used kmno4 and chromic acid for such reaction as describe, its very messy and the chormic waste is highly carcinogenic and the yield is shit. filteration is slow to get rid of it especially so if you are doing it at home lab without proper equipment it will be worse. it will be really a messy sticky junk.
actually its not really that hard to figure out how to do it if you have friends currently studying in university. any course will do, any university will have a scifinder account. its a "science" google, play around with it any synthetic route can be easily found and details steps on how to go about doing it is there as well.
there used to be a very good site with very details descriptions on such thing, i think its call Radium or something. in fact i would recommend any organic new graduate students to go in have a look. cos it contain many important basic skill that is very useful for educational purpose. although the content there is more about how to make illegal drugs LOL
actually its not really that hard to figure out how to do it if you have friends currently studying in university. any course will do, any university will have a scifinder account. its a "science" google, play around with it any synthetic route can be easily found and details steps on how to go about doing it is there as well.
there used to be a very good site with very details descriptions on such thing, i think its call Radium or something. in fact i would recommend any organic new graduate students to go in have a look. cos it contain many important basic skill that is very useful for educational purpose. although the content there is more about how to make illegal drugs LOL
Last edited:
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Yes the infor I found is from a trained chemist who turn haywired
if I can get hold of those chemicals .. I will try . But for now I will just stick to meth . Going to find a guinea pig When done 
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Over in Japan its also not easy to get those chemicals .. But if u knew "ppl " it's not that difficult to obtain those chemicals
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