How Effective Are Antidepressants?

[Leongsam]

https://www.antidepressantrisks.org/​

​

How Effective Are Antidepressants?​

Opinion is divided as to how well antidepressants work.

There is little data on long term outcomes as the drugs are only tested for 6-8 weeks by the pharmaceutical companies that make them.

Data on short term effectiveness is also limited because drug companies are not obliged to publish all of their trials.

In their guide to taking antidepressants The Royal College of Psychiatrists state: 'Overall research shows antidepressants help to reduce the symptoms of moderate and severe depression in adults. But different people have very different experiences with these medications.' Link

Some clinicians believe they are no more effective than a placebo.

In 2008 Dr Irving Kirsch from Harvard Medical School and a group of researchers acquired the unpublished trials for six antidepressants using the Freedom of Information Act (U.S.). They discovered that the drugs produced a small but clinically meaningless improvement in mood compared to a placebo for mild to moderate depression. Antidepressants and the Placebo Effect.

Other studies have reached a range of differing conclusions.


More than half of patients will experience negative side effects from taking antidepressants.

The NHS, Mayo Clinic and others list these as:

• agitation
• sickness
• indigestion and stomach aches
• diarrhoea, constipation
• insomnia
• headaches
• blurring of vision
• drowsiness
• problems passing urine
• dry mouth
• weight gain
• excessive sweating
• low sex drive
• heart rhythm problems

According to published data, more than 50% of users experience sexual dysfunction. In men this can mean delayed ejaculation and erectile dysfunction and in women difficulties achieving orgasm. In both there can be a loss of libido.

Because withdrawal from antidepressants can be so hard, millions will have to put up with these side effects for life. For some who manage to stop the sexual problems can get worse and become permanent.
Serotonin syndrome is a potentially life threatening condition that can be triggered by a single dose of an antidepressant. Symptoms can include confusion, agitation, muscle twitching, sweating, shivering, diarrhoea, fits, unconsciousness and psychosis.

The NHS and similar websites around the world advise that if you experience any of the above symptoms of serotonin syndrome you should stop taking the medicine and seek immediate advice from your GP, specialist or emergency services.
A very common sign that someone is having a dangerous reaction to medication is that they develop a condition called akathisia. This may sometimes show as an inability to keep still so the person paces frenetically and is unable to sleep.

The feeling of being compelled to keep moving has been described as torturous.

One sufferer said of akathisia, "Death can be a welcome result".

Even more common is an intense inner restlessness and an emotional turmoil without any motor movements.

Akathisia can lead sufferers to harm and kill themselves or others.




The most dangerous time for those who react adversely to antidepressants is the first few weeks after going on them, around any change of dose (up or down), during and after withdrawal.

Hooked on Antidepressants - The Evidence​

There is now evidence that millions are trapped into taking antidepressants indefinitely because withdrawal symptoms are so severe.

According to a review of studies led by the University of Roehampton more than half (56%) of people who stopped or reduced their intake of antidepressants experienced withdrawal symptoms, with almost half of these people (46% ) reporting symptoms as severe.

These include insomnia, stomach problems, headaches, panic attacks, anxiety, suicidal thoughts, mania, depersonalisation and depression.

In some cases reactions are so severe that patients report 'brain zaps' - these are electrical shock sensations in the brain which may extend down the body.

Withdrawal effects can be so debilitating that many people are unable to function and some people simply cannot stop.

Common Side Effects​

Extreme Reactions​

Serotonin Syndrome​

Extreme Outcomes​

Akathisia​

Suicide​

JON​

Jon took his own life days after taking citalopram.
Click here to read about Jon.

Homicide and Violence​

Kurt served 24 years for killing his father after a violent reaction to Prozac.
Click here to read Kurt's story.

Kurt's story

KURT​

It can take many months or years to come off antidepressants safely.



In
recognition of this problem, Public Health England has recommended a
national helpline to help people withdraw from antidepressants.



The Royal College of Psychiatrists have published a guide - Stopping Antidepressants.
With thanks to MISSD

Dr. Ed White's story
Dr. Ed White was a co-founder of this website. He suffered debilitating withdrawal effects and took his life in October 2021
Click here to read Ed's story.

ED​

Mission​

• People can suffer debilitating side effects that may continue after they stop the drug.
• Millions of people have no choice but to take antidepressants for life simply because the withdrawal effects are so severe.
• Around 1 in 100 people on antidepressants can become violent or suicidal.

"While these drugs help some people in the short term, there is growing evidence that long term use leads to worse outcomes and many patients report devastating persistent withdrawal and other negative effects"

2019 British Parliamentary Inquiry

Warning​

The most extreme reactions to antidepressants, including suicide and violence, are more common when the dosage of an antidepressant changes or when starting or discontinuing the medication. Sometimes these reactions are caused by switching from one type of antidepressant to another. Anyone considering altering the dosage of their medication or withdrawing from it should take medical advice first from a doctor or suitably qualified practitioner. Some doctors are unaware of these issues so you may need to find one who recognises the problems and can support you.

Although some of our contributors and team members may work as practitioners, all of the final editorial decisions related to the content of this website have been made by non-medical people and are provided for general educational purposes only. None of the information and resources on the Antidepressant Risks website or provided in any communication constitutes or should be seen as medical, mental health, counselling, clinical or professional advice of any kind. For a full copy of our disclaimer please click here.
[email protected]

 

[Leongsam]

 

[Leongsam]

Ryan Michael Ballow
Ryan Michael Ballow
6 months ago (edited)
So let's break this down a little bit.

1. Still, as has been the case for years, Healy et al do a great job of talking about the condition. Which is where it ends. Healy and ilk are not running active trials on real people, executing combinations of safe chemicals, to target theoretically downed neurotransmission. This is a problem. Which is a great segue to..

2. If we leave this up to the establishment (IE: pharmacologists, mere writers and speakers, and others that play largely an observatory role), the condition will remain as it is, all consuming, and painfully elusive solution wise.

3. Some of what was said here is wrong, and bad advice. As an example: downed auto-receptor function, and thus, a ghost train of serotonin. This cannot be true. Berberine, a chemical plenty in the community has experimented with, should be close to resolving the issue, IF the auto-receptor theory is correct. Berberine would activate the 1A autoreceptor at the first stop (somatodendritic), and inhibit post synaptic 1A and 2A receptors. It does, actually, but yet, the problem remains.

In the many PSSD forums, scores of men have experimented with both Berberine, and a modified BCAA regimen to inhibit serotonin synthesis, and alas, still get next to no results, and some, get worse. Neither of these are remotely close to a solution or treatment for PSSD.

Mirtazapin (Mirtazapine) is touted as a treatment in this video. Or a way to positively augment the condition. When in reality, Mirtazapine itself has caused non-SSRI PSSD in many people. I have proof of this and would go on the record any day about it.

4. And again, what we have here are people in the scientific community doing much of what they know how to do, (talk in circles about PSSD, with no real routes to solutions) obviously lacking what we know they can't do: put boots on the ground to achieve persistent, significant symptom relief.

5. Many of us that are actively working with real people to solve the issue (because this condition will only be solved outside of the establishment, not IN the circle that created it), have reached out to the establishment behind this video, only to be scoffed at as if we don't have the expertise to tackle such a task. In no uncertain terms, that is harmful to the community of sufferers. I cannot make that any more clear.

6. The sensory organs spoke of, as if the issue lies or ROOTS within them, get their signaling from the spinal chord and brain. This is neurotransmitter signaling gone awry. Not some nebulous deficiency in sensory organ function. The pure registration of these signals takes place in the brain.

7. There is usually next to NO discussion about acetylcholine, one of the most important neurotransmitters in this dynamic.

8. Serotonin itself is observed as the enemy, when in reality it is not. No regular man, with normal sexual function, has some deficiency in serotonin signaling. This is just untrue, prevents the community from moving forward, and is harmful, at best.

And plenty more I could go on about for hours.

The condition is solvable, if people are looking in the right place. Which is OUT of the pharmaceutical medicine dynamic, and deep in the depths of self/guided experimentation, with compounds that are addressing the more LIKELY chemistry behind PSSD.

When the establishment catches up to the work that some of the pioneers of PSSD resolution have done, then we'll be making large scale progress. Until then, we'll continue being reduced (at least from these inputs here) to mere discussion.

What this video tells us is, that the groups behind the discussion here, have made precisely zero advancements in solving the condition.

 

[Dr Christopher Cheok C S]

 

[mahjongking]

dont anyhow take medicine or drugs unless you are in great physical pain.......

 

[LordElrond]

When I’m depressed I come here to read anti-vax posts and immediately I’m cured.

 

[mahjongking]

me? i just come to fuck cheebye loong and i am good again

 

[glnit]

depression?
just listen to g'old joe rogan and trip up on DMT
the spirit molecule will re-wire our synapses and cure any depressive loops
we'll meet not only the elfs, jokers but our personal maker as well
buddhist monks who took it compared the experience to temporary samsara
hindus would remark that we've managed to ply open our 3rd-eye
depression?
antidepressants are the last shit you wanna take

 

[SBFNews]

If a person hears knocking sound everyday, do you think she needs to take antidepressants?

 

[Datingafter35]

I

https://www.antidepressantrisks.org/​

​

How Effective Are Antidepressants?​

Opinion is divided as to how well antidepressants work.

There is little data on long term outcomes as the drugs are only tested for 6-8 weeks by the pharmaceutical companies that make them.

Data on short term effectiveness is also limited because drug companies are not obliged to publish all of their trials.

In their guide to taking antidepressants The Royal College of Psychiatrists state: 'Overall research shows antidepressants help to reduce the symptoms of moderate and severe depression in adults. But different people have very different experiences with these medications.' Link

Some clinicians believe they are no more effective than a placebo.

In 2008 Dr Irving Kirsch from Harvard Medical School and a group of researchers acquired the unpublished trials for six antidepressants using the Freedom of Information Act (U.S.). They discovered that the drugs produced a small but clinically meaningless improvement in mood compared to a placebo for mild to moderate depression. Antidepressants and the Placebo Effect.

Other studies have reached a range of differing conclusions.


More than half of patients will experience negative side effects from taking antidepressants.

The NHS, Mayo Clinic and others list these as:

• agitation
• sickness
• indigestion and stomach aches
• diarrhoea, constipation
• insomnia
• headaches
• blurring of vision
• drowsiness
• problems passing urine
• dry mouth
• weight gain
• excessive sweating
• low sex drive
• heart rhythm problems

According to published data, more than 50% of users experience sexual dysfunction. In men this can mean delayed ejaculation and erectile dysfunction and in women difficulties achieving orgasm. In both there can be a loss of libido.

Because withdrawal from antidepressants can be so hard, millions will have to put up with these side effects for life. For some who manage to stop the sexual problems can get worse and become permanent.
Serotonin syndrome is a potentially life threatening condition that can be triggered by a single dose of an antidepressant. Symptoms can include confusion, agitation, muscle twitching, sweating, shivering, diarrhoea, fits, unconsciousness and psychosis.

The NHS and similar websites around the world advise that if you experience any of the above symptoms of serotonin syndrome you should stop taking the medicine and seek immediate advice from your GP, specialist or emergency services.
A very common sign that someone is having a dangerous reaction to medication is that they develop a condition called akathisia. This may sometimes show as an inability to keep still so the person paces frenetically and is unable to sleep.

The feeling of being compelled to keep moving has been described as torturous.

One sufferer said of akathisia, "Death can be a welcome result".

Even more common is an intense inner restlessness and an emotional turmoil without any motor movements.

Akathisia can lead sufferers to harm and kill themselves or others.




The most dangerous time for those who react adversely to antidepressants is the first few weeks after going on them, around any change of dose (up or down), during and after withdrawal.

Hooked on Antidepressants - The Evidence​

There is now evidence that millions are trapped into taking antidepressants indefinitely because withdrawal symptoms are so severe.

According to a review of studies led by the University of Roehampton more than half (56%) of people who stopped or reduced their intake of antidepressants experienced withdrawal symptoms, with almost half of these people (46% ) reporting symptoms as severe.

These include insomnia, stomach problems, headaches, panic attacks, anxiety, suicidal thoughts, mania, depersonalisation and depression.

In some cases reactions are so severe that patients report 'brain zaps' - these are electrical shock sensations in the brain which may extend down the body.

Withdrawal effects can be so debilitating that many people are unable to function and some people simply cannot stop.

Common Side Effects​

Extreme Reactions​

Serotonin Syndrome​

Extreme Outcomes​

Akathisia​

Suicide​

JON​

Jon took his own life days after taking citalopram.
Click here to read about Jon.

Homicide and Violence​

Kurt served 24 years for killing his father after a violent reaction to Prozac.
Click here to read Kurt's story.

Kurt's story

KURT​

It can take many months or years to come off antidepressants safely.



In
recognition of this problem, Public Health England has recommended a
national helpline to help people withdraw from antidepressants.



The Royal College of Psychiatrists have published a guide - Stopping Antidepressants.
With thanks to MISSD

Dr. Ed White's story
Dr. Ed White was a co-founder of this website. He suffered debilitating withdrawal effects and took his life in October 2021
Click here to read Ed's story.

ED​

Mission​

• People can suffer debilitating side effects that may continue after they stop the drug.
• Millions of people have no choice but to take antidepressants for life simply because the withdrawal effects are so severe.
• Around 1 in 100 people on antidepressants can become violent or suicidal.

"While these drugs help some people in the short term, there is growing evidence that long term use leads to worse outcomes and many patients report devastating persistent withdrawal and other negative effects"

2019 British Parliamentary Inquiry

Warning​

The most extreme reactions to antidepressants, including suicide and violence, are more common when the dosage of an antidepressant changes or when starting or discontinuing the medication. Sometimes these reactions are caused by switching from one type of antidepressant to another. Anyone considering altering the dosage of their medication or withdrawing from it should take medical advice first from a doctor or suitably qualified practitioner. Some doctors are unaware of these issues so you may need to find one who recognises the problems and can support you.

Although some of our contributors and team members may work as practitioners, all of the final editorial decisions related to the content of this website have been made by non-medical people and are provided for general educational purposes only. None of the information and resources on the Antidepressant Risks website or provided in any communication constitutes or should be seen as medical, mental health, counselling, clinical or professional advice of any kind. For a full copy of our disclaimer please click here.
[email protected]

I'm also experience the same thing. MOM force employers to kick non vaccinated individuals to quit and now I am going to be out of work for a job I like because of the women colleagues but more importantly because I can hack obstacles. I loathe the workload though.

I have Gerd. I can't raise my heart rate without feeling breathless.

I feel extremely satisfied when I watch porn and do pushup or workout then I empty my nuts.

Workouts should be the best anti depressant but now all I do is sleep.

I want to go back to something I sucked at like trading forex and following Russell Brunson disillusioned of selling what you know not why you cannot do.

 

[jw5]

I

I'm also experience the same thing. MOM force employers to kick non vaccinated individuals to quit and now I am going to be out of work for a job I like because of the women colleagues but more importantly because I can hack obstacles. I loathe the workload though.

I have Gerd. I can't raise my heart rate without feeling breathless.

I feel extremely satisfied when I watch porn and do pushup or workout then I empty my nuts.

Workouts should be the best anti depressant but now all I do is sleep.

I want to go back to something I sucked at like trading forex and following Russell Brunson disillusioned of selling what you know not why you cannot do.

It would be great if you have pictures of the women colleagues.

 

[liamricci]

Not at all!

 

[syed putra]

When I’m depressed I come here to read anti-vax posts and immediately I’m cured.

Well done. I hope i am part of your " cure".

 

[syed putra]

I

I'm also experience the same thing. MOM force employers to kick non vaccinated individuals to quit and now I am going to be out of work for a job I like because of the women colleagues but more importantly because I can hack obstacles. I loathe the workload though.

I have Gerd. I can't raise my heart rate without feeling breathless.

I feel extremely satisfied when I watch porn and do pushup or workout then I empty my nuts.

Workouts should be the best anti depressant but now all I do is sleep.

I want to go back to something I sucked at like trading forex and following Russell Brunson disillusioned of selling what you know not why you cannot do.

Nothing like a vigorous workout plus if possible, a woman to pump. When down, a hefty dose of exercise normally will put things right. And then start thinking about crazy ideas to market. Brains need to excercise too.

 

[Norty]

Well, maybe antidepressants are effective, but I think it is better to try natural ways of treatment first. My sister had to take antidepressants and I saw what those meds made with her. I checked the info about them on the canada drugs site and was frightened by the possible side effects. Fortunately, she went through the therapy, changed her lifestyle and is doing much better now.

 

[nightsafari]

but please let's not call it that otherwise it gets lumped together with the garbage drugs. How about natural mood enhancer?

 

[nightsafari]

If a person hears knocking sound everyday, do you think she needs to take antidepressants?

depends. the knocking coming from your headboard while banging your chiobu or the knocking when bill collector comes.

 

[Loofydralb]

Muslims have an antidote for depression.

In Quran 13:28
"those who believe and whose hearts find comfort in the remembrance of Allah. Surely in the remembrance of Allah do hearts find comfort."

And it works!