Eczema significantly increased the risk of hematological cancer Hodgkin's lymphoma, myeloma & significantly decrease the risk of lymphocytic leukemia

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Front Med (Lausanne)
. 2022 Jun 29;9:912136. doi: 10.3389/fmed.2022.912136

Potential Correlation Between Eczema and Hematological Malignancies Risk: A Systematic Review and Meta-Analysis​

Zuohui Liang 1,†, Jie Liu 2,†, Hongxia Jin 3,†, Yirong Teng 4, Shuangyan Xu 1, Weimin Yan 1, Yun Zhu 1,5,*

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PMCID: PMC9277696 PMID: 35847819

Abstract​

Background​

Eczema characterized by itch, sleeplessness, and adverse effects on quality of life is associated with a risk of hematological malignancies. However, there is a controversy pertaining to whether this association implies a greater or lesser risk of hematological cancers. We aimed to explore the link between eczema and hematological malignancies risk.

 

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Methods​

We systematically searched PubMed and Embase databases from their inception to February 17, 2022. Two reviewers independently screened articles, extracted data and assessed study quality, respectively. The odds ratios and 95% confidence intervals (CIs) were pooled by using fixed or random-effects models.

Results​

29 studies involving 2,521,574 participants examined the contribution of eczema to hematological malignancies. We found that eczema significantly increased the risk of Hodgkin's lymphoma (1.44; 95% CI, 1.07–1.95), myeloma (1.15; 95% CI, 1.04–1.28), and significantly decreased the risk of lymphocytic leukemia (0.91; 95% CI, 0.84–0.99); however, it is not significantly associated with Non-Hodgkin's lymphoma, and myelocytic leukemia.

Conclusion​

Eczema has been shown to be associated with the risk of hematological cancer, this association still needs to be verified in large randomized controlled trials.

 

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Results​

29 studies involving 2,521,574 participants examined the contribution of eczema to hematological malignancies. We found that eczema significantly increased the risk of Hodgkin's lymphoma (1.44; 95% CI, 1.07–1.95), myeloma (1.15; 95% CI, 1.04–1.28), and significantly decreased the risk of lymphocytic leukemia (0.91; 95% CI, 0.84–0.99); however, it is not significantly associated with Non-Hodgkin's lymphoma, and myelocytic leukemia

Hodgkin lymphoma is marked by the presence of Reed-Sternberg lymphocytes, which a physician can identify using a microscope. In non-Hodgkin lymphoma, these cells are not present.

https://www.moffitt.org › faqs › h...

Hodgkin Lymphoma vs. Non-Hodgkin Lymphoma | Moffitt​

 

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Hodgkin lymphoma is marked by the presence of Reed-Sternberg lymphocytes, which a physician can identify using a microscope. In non-Hodgkin lymphoma, these cells are not present.

https://www.moffitt.org › faqs › h...

Hodgkin Lymphoma vs. Non-Hodgkin Lymphoma | Moffitt​

Lymphocytes​

Lymphocytes are a type of white blood cell. They help your body’s immune system fight cancer and foreign viruses and bacteria. Your lymphocyte count can be taken during a normal blood test at your healthcare provider’s office. Lymphocyte levels vary depending on your age, race, sex, altitude and lifestyle.

 

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A number of studies show that people with RA have roughly double the average risk for developing lymphoma, a group of cancers that arise in the blood. This is likely caused by chronic inflammatory stimulation of the immune system.

https://www.arthritis.org › arthritis-a...

Rheumatoid Arthritis and Cancer Risk​