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A famous example was Luther Vandross, who struggled with his weight his entire life, yo-yoing between 340 and 190 lbs. When he finally found the secret to losing weight and keeping it off (at about 220 lbs), it was basically high proteins, lots of veggie and zero carbs – on 900 Cals a day!
Even a 40 kg woman can't survive on 900 Cals a day, but Luther could, and needed to, to maintain his weight at 220 lbs. If that's not genetics I don't know what is.
He was fat because he didn't burn enough calories. When I was in school the only fatties were the sons of rich pricks. The rest of us weren't chauferred around we had to move our own asses and were decidedly skinny by today's standards.