Yoon, S.-J., Yu, M.-A., Pyun, Y.-R., Hwang, J.-K., Chu, D.-C., Juneja, L. R., & Mourão, P. A. S. (2003). The nontoxic mushroom Auricularia auricula contains a polysaccharide with anticoagulant activity mediated by antithrombin. Thrombosis research, 112(3), 151–158. doi:10.1016/j.thromres.2003.10.022
An acidic polysaccharide with anticoagulant activity was isolated from the edible mushroom Auricularia auricula using water, alkali or acid extracts. The alkali extract showed the highest anticoagulant activity and was thereby further purified using gel filtration chromatography. Specific anticoagulant activity of the purified polysaccharide was 2 IU/mg and its average mass was approximately 160 kDa. The polysaccharide from this species of mushroom contains mainly mannose, glucose, glucuronic acid and xylose but no sulfate esters. Its anticoagulant activity was due to catalysis of thrombin inhibition by antithrombin but not by heparin cofactor II. Inhibition of Factor Xa by antithrombin was not catalyzed by the polysaccharide. The glucuronic acid residues were essential for the anticoagulant action of the mushroom polysaccharide since the activity disappeared after reduction of its carboxyl groups. In ex vivo tests using rats orally fed with the polysaccharide, we observed an inhibitory effect on platelet aggregation as observed with aspirin, a well-known antiplatelet agent. The polysaccharides from these mushrooms may constitute a new source of compounds with action on coagulation, platelet aggregation and, perhaps, on thrombosis.
http://www.ncbi.nlm.nih.gov/pubmed/14967412
Fan, Y. M., Xu, M. Y., Wang, L. Y., Zhang, Y., Zhang, L., Yang, H., … Cui, P. (1989). The effect of edible black tree fungus (Auricuaria auricula) on experimental atherosclerosis in rabbits. Chinese medical journal, 102(2), 100–105.
The effects of edible black tree fungus (BFF) compared with aspirin on serum lipid level and experimental atherosclerosis and thrombosis in rabbits were studied. The results showed that total serum cholesterol and B-lipoprotein of the BTF group were significantly decreased (P less than 0.01) than the aspirin group and the group with neither BTF nor aspirin. There were less aortic atherosclerotic plaque and intramyocardial arterial lumen stenosis in the BTF group. The development of thrombus and platelet aggregation and thromboxane TXB2 level were inhibited both in the BTF and aspirin group (P less than 0.01). These findings indicate BTF may be used as a healthy food in preventing atherosclerosis and coronary heart disease, but its mechanism requires further investigation.
http://www.ncbi.nlm.nih.gov/pubmed/2505974
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Others:
An acidic polysaccharide with anticoagulant activity was isolated from the edible mushroom Auricularia auricula using water, alkali or acid extracts. The alkali extract showed the highest anticoagulant activity and was thereby further purified using gel filtration chromatography. Specific anticoagulant activity of the purified polysaccharide was 2 IU/mg and its average mass was approximately 160 kDa. The polysaccharide from this species of mushroom contains mainly mannose, glucose, glucuronic acid and xylose but no sulfate esters. Its anticoagulant activity was due to catalysis of thrombin inhibition by antithrombin but not by heparin cofactor II. Inhibition of Factor Xa by antithrombin was not catalyzed by the polysaccharide. The glucuronic acid residues were essential for the anticoagulant action of the mushroom polysaccharide since the activity disappeared after reduction of its carboxyl groups. In ex vivo tests using rats orally fed with the polysaccharide, we observed an inhibitory effect on platelet aggregation as observed with aspirin, a well-known antiplatelet agent. The polysaccharides from these mushrooms may constitute a new source of compounds with action on coagulation, platelet aggregation and, perhaps, on thrombosis.
http://www.ncbi.nlm.nih.gov/pubmed/14967412
Fan, Y. M., Xu, M. Y., Wang, L. Y., Zhang, Y., Zhang, L., Yang, H., … Cui, P. (1989). The effect of edible black tree fungus (Auricuaria auricula) on experimental atherosclerosis in rabbits. Chinese medical journal, 102(2), 100–105.
The effects of edible black tree fungus (BFF) compared with aspirin on serum lipid level and experimental atherosclerosis and thrombosis in rabbits were studied. The results showed that total serum cholesterol and B-lipoprotein of the BTF group were significantly decreased (P less than 0.01) than the aspirin group and the group with neither BTF nor aspirin. There were less aortic atherosclerotic plaque and intramyocardial arterial lumen stenosis in the BTF group. The development of thrombus and platelet aggregation and thromboxane TXB2 level were inhibited both in the BTF and aspirin group (P less than 0.01). These findings indicate BTF may be used as a healthy food in preventing atherosclerosis and coronary heart disease, but its mechanism requires further investigation.
http://www.ncbi.nlm.nih.gov/pubmed/2505974
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Others:
- http://www.globalgourmet.com/food/special/1999/asian/fungus.html
- http://www.livestrong.com/article/329389-benefits-of-black-fungus/
- http://www.shanghaiexpat.com/phpbbforum/black-fungus-mok-yee-t108912.html
can it be eaten raw?
