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Big pharma halts distribution of anti-smoking drug after finding carcinogen

Putting NNTs into perspective

As a general rule of thumb, an NNT of 5 or under for treating a symptomatic condition is usually considered to be acceptable and in some cases even NNTs below 10.

Number Needed to Treat (NNT)​

 
https://www.aafp.org/afp/2017/0901/od1.htm

VARENICLINE (CHANTIX) FOR SMOKING CESSATION​

BENEFITS​
HARMS​
1 in 11 stopped smoking​
1 in 5 had nausea​
1 in 15 had abnormal dreams​
1 in 23 had insomnia​
1 in 50 had headache​
1 in 143 had serious adverse events (infections, cancers, injuries)​
 
Number needed to treat - Wikipedia

Why is NNT important?

Relevance. The NNT is an important measure in pharmacoeconomics. If a clinical endpoint is devastating enough (e.g. death, heart attack), drugs with a high NNTmay still be indicated in particular situations. If the endpoint is minor, health insurers may decline to reimburse drugs with a high NNT.
 
What is the NNT for statins?

Statins, which have become synonymous with “heart-attack-and-stroke-preventing,” have an NNT of 60 for heart attack and 268 for stroke: That's how many healthy people have to take statins for five years for those respective outcomes to be prevented.15 Jun 2016
 
What is NNT and ADR?

Come to think of it our drugs help one and harm 45! The same for statins, NNT is 300 and side effects (ADR) 10%. Taking statins might help one in three hundred but will make 30 of them diabetics in one year and has many other dangerous side effects!
 
NNT and NNH

Number needed to harm is similar to number Number needed to treat (NNT); While NNH is a measure of harm or adverse effects, NNT is a measure of how many patients needed to be treated in order for one to benefit. Together, these statistics help physicians decide on courses of treatment.6 Mar 2017

Number Needed to Harm NNH: Definition - Statistics How To​

 
NNT and NNH

Number needed to harm is similar to number Number needed to treat (NNT); While NNH is a measure of harm or adverse effects, NNT is a measure of how many patients needed to be treated in order for one to benefit. Together, these statistics help physicians decide on courses of treatment.6 Mar 2017

Number Needed to Harm NNH: Definition - Statistics How To

NEH NEH TUA AND NEH NEH HIONG aka smelly NEH NEH
 
What is NNT and ADR?

Come to think of it our drugs help one and harm 45! The same for statins, NNT is 300 and side effects (ADR) 10%. Taking statins might help one in three hundred but will make 30 of them diabetics in one year and has many other dangerous side effects!
ADR = adverse drug reaction
 
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