An Unsinkable Ex-Naval Occifer Thread

[Kee Chew]

457 comments

 

[millim6868]

Poodles are sleeping ,they see person cannot makan they sure acz blur,maybe she related to PAPigs or maybecsome business partner so no arrest, PAPigs only arrest pooer sinkies peasants like the locsl indian thaz scokd ceca for not putting on mask

 

[millim6868]

Realky ugly fat CB ,trying to act atas, damn CB

 

[LITTLEREDDOT]

 

[Pinkieslut]

Not bad quite chio

 

[LITTLEREDDOT]

She is a courageous lady with principles.

If all Sinkies are fed up with the PAP government's double standard in blaming Sinkies for the rise in covid-19 cases while continuing to allow incoming travellers from India, and if all Sinkies have lockdown fatigue, all Sinkies should revolt and stop wearing masks.

 

[Scrooball (clone)]

She is a courageous lady with principles.

If all Sinkies are fed up with the PAP government's double standard in blaming Sinkies for the rise in covid-19 cases while continuing to allow incoming travellers from India, and if all Sinkies have lockdown fatigue, all Sinkies should revolt and stop wearing masks.

Courageous? She go and lead a hunger strike outside Istana la. haha....

People these days don't know the difference between 'courage' and 'asshole'.

 

[aerobwala]

 

[aerobwala]

 

[aerobwala]

 

[syed putra]

My badge

 

[aerobwala]

 

[CSY888]

WHAT A UGLY FACE , AT HOME NO MIRROR? THIS PERSON DOESN'T KNOW WHERE AND WHAT LEVEL SHE IS.

 

[syed putra]

She must be some kind of a corporate lawyer.

 

[Splendicker]

What next.... Did the authority follow up her case?

 

[Scrooball (clone)]

View attachment 110841

My badge

Huh i don't understand this posting. Are u saying the woman in this photo is the same as the old cunt?

 

[sweetiepie]

https://www.sammyboy.com/threads/usa-angmoh-government-the-best-again.304361/unread
@ginfreely lu puki babi perlacur

 

[Splendicker]

Poodles are sleeping ,they see person cannot makan they sure acz blur,maybe she related to PAPigs or maybecsome business partner so no arrest, PAPigs only arrest pooer sinkies peasants like the locsl indian thaz scokd ceca for not putting on mask

 

[syed putra]

That’s why I advocate for older people above 60 to be euthanized. That will lessen the burden of the youths and create less strain on infrastructure and resources.

60 is the new 40. Many are still strong and willing at 60.

 

[capamerica]

She obviously knows that masks don't work and can make things worse.

Wrong. Again. Call it 0 for 226 tries.

https://www.pnas.org/content/118/4/e2014564118

An evidence review of face masks against COVID-19​

View ORCID ProfileJeremy Howard, Austin Huang, View ORCID ProfileZhiyuan Li, View ORCID ProfileZeynep Tufekci, Vladimir Zdimal, View ORCID ProfileHelene-Mari van der Westhuizen, View ORCID ProfileArne von Delft, View ORCID ProfileAmy Price, Lex Fridman, View ORCID ProfileLei-Han Tang, View ORCID ProfileViola Tang, View ORCID ProfileGregory L. Watson, View ORCID ProfileChristina E. Bax, View ORCID ProfileReshama Shaikh, View ORCID ProfileFrederik Questier, Danny Hernandez, View ORCID ProfileLarry F. Chu, View ORCID ProfileChristina M. Ramirez, and View ORCID ProfileAnne W. Rimoin

See all authors and affiliations
PNAS January 26, 2021 118 (4) e2014564118; https://doi.org/10.1073/pnas.2014564118

1. Edited by Lauren Ancel Meyers, The University of Texas at Austin, Austin, TX, and accepted by Editorial Board Member Nils C. Stenseth December 5, 2020 (received for review July 13, 2020)

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Abstract​

The science around the use of masks by the public to impede COVID-19 transmission is advancing rapidly. In this narrative review, we develop an analytical framework to examine mask usage, synthesizing the relevant literature to inform multiple areas: population impact, transmission characteristics, source control, wearer protection, sociological considerations, and implementation considerations. A primary route of transmission of COVID-19 is via respiratory particles, and it is known to be transmissible from presymptomatic, paucisymptomatic, and asymptomatic individuals. Reducing disease spread requires two things: limiting contacts of infected individuals via physical distancing and other measures and reducing the transmission probability per contact. The preponderance of evidence indicates that mask wearing reduces transmissibility per contact by reducing transmission of infected respiratory particles in both laboratory and clinical contexts. Public mask wearing is most effective at reducing spread of the virus when compliance is high. Given the current shortages of medical masks, we recommend the adoption of public cloth mask wearing, as an effective form of source control, in conjunction with existing hygiene, distancing, and contact tracing strategies. Because many respiratory particles become smaller due to evaporation, we recommend increasing focus on a previously overlooked aspect of mask usage: mask wearing by infectious people (“source control”) with benefits at the population level, rather than only mask wearing by susceptible people, such as health care workers, with focus on individual outcomes. We recommend that public officials and governments strongly encourage the use of widespread face masks in public, including the use of appropriate regulation.

• COVID-19
• SARS-CoV-2
• masks
• pandemic

Policy makers need urgent guidance on the use of masks by the general population as a tool in combating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the respiratory virus that causes COVID-19. Masks have been recommended as a potential tool to tackle the COVID-19 pandemic since the initial outbreak in China (1), although usage during the outbreak varied by time and location (2). Globally, countries are grappling with translating the evidence of public mask wearing to their contexts. These policies are being developed in a complex decision-making environment, with a novel pandemic, rapid generation of new research, and exponential growth in cases and deaths in many regions. There is currently a global shortage of N95/FFP2 respirators and surgical masks for use in hospitals. Simple cloth masks present a pragmatic solution for use by the public. This has been supported by most health bodies. We present an interdisciplinary narrative review of the literature on the role of face masks in reducing COVID-19 transmission in the community.

Background​

Wu Lien Teh’s work to control the 1910 Manchurian Plague has been acclaimed as “a milestone in the systematic practice of epidemiological principles in disease control” (3), in which Wu identified the cloth mask as “the principal means of personal protection.” Although Wu designed the cloth mask that was used through most of the world in the early 20th century, he pointed out that the airborne transmission of plague was known since the 13th century, and face coverings were recommended for protection from respiratory pandemics since the 14th century (4). Wu reported on experiments that showed a cotton mask was effective at stopping airborne transmission, as well as on observational evidence of efficacy for health care workers. Masks have continued to be widely used to control transmission of respiratory infections in East Asia through to the present day, including for the COVID-19 pandemic (5).
In other parts of the world, however, mask usage in the community had fallen out of favor, until the impact of COVID-19 was felt throughout the world, when the discarded practice was rapidly readopted. By the end of June 2020, nearly 90% of the global population lived in regions that had nearly universal mask use, or had laws requiring mask use in some public locations (6), and community mask use was recommended by nearly all major public health bodies. This is a radical change from the early days of the pandemic, when masks were infrequently recommended or used.

Direct Evidence of the Efficacy of Public Mask Wearing​

If there is strong direct evidence, either a suitably powered randomized controlled trial (RCT), or a suitably powered metaanalysis of RCTs, or a systematic review of unbiased observational studies that finds compelling evidence, then that would be sufficient for evaluating the efficacy of public mask wearing, at least in the contexts studied. Therefore, we start this review looking at these types of evidence.

Direct Epidemiological Evidence.​

Cochrane (7) and the World Health Organization (8) both point out that, for population health measures, we should not generally expect to be able to find controlled trials, due to logistical and ethical reasons, and should therefore instead seek a wider evidence base. This issue has been identified for studying community use of masks for COVID-19 in particular (9). Therefore, we should not be surprised to find that there is no RCT for the impact of masks on community transmission of any respiratory infection in a pandemic.
Only one observational study has directly analyzed the impact of mask use in the community on COVID-19 transmission. The study looked at the reduction of secondary transmission of SARS-CoV-2 in Beijing households by face mask use (10). It found that face masks were 79% effective in preventing transmission, if they were used by all household members prior to symptoms occurring. The study did not look at the relative risk of different types of mask.
In a systematic review sponsored by the World Health Organization, Chu et al. (11) looked at physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2. They found that “face mask use could result in a large reduction in risk of infection.” However, the review included only three studies of mask use outside health care settings, all of which were of SARS, not of SARS-CoV-2, one of which was incorrectly categorized (it occurred in a hospital, but during family and friend visits), and one of which found that none of the households wearing masks had any infections, but was too underpowered to draw any conclusions (12). The remaining study found the use of masks was strongly protective, with a risk reduction of 70% for those that always wore a mask when going out (13), but it did not look at the impact of masks on transmission from the wearer. It is not known to what degree analysis of other coronaviruses can be applied to SARS-CoV-2. None of the studies looked at the relative risks of different types of mask.
There has been one controlled trial of mask use for influenza control in the general community (14). The study looked at Australian households, was not done during a pandemic, and was done without any enforcement of compliance. It found that “in an adjusted analysis of compliant subjects, masks as a group had protective efficacy in excess of 80% against clinical influenza-like illness.” However, the authors noted that they “found compliance to be low, but compliance is affected by perception of risk. In a pandemic, we would expect compliance to improve.” In compliant users, masks were highly effective at reducing transmission.
Overall, evidence from RCTs and observational studies is informative, but not compelling on its own. Both the Australian influenza RCT and the Beijing households observational trial found around 80% efficacy among compliant subjects, and the one SARS household study of sufficient power found 70% efficacy for protecting the wearer. However, we do not know whether the results from influenza or SARS will correspond to results for SARS-CoV-2, and the single observational study of SARS-CoV-2 might not be replicated in other communities. None of the studies looked specifically at cloth masks.

Reviews and RCTs of Mask Use for Other Respiratory Illnesses.​

A number of reviews have investigated masks during nonpandemic outbreaks of influenza and other respiratory diseases. It is not known to what degree these findings apply to pandemic SARS-CoV-2. When evaluating the available evidence for the impact of masks on community transmission, it is critical to clarify the setting of the research study (health care facility or community), whether masks are evaluated as source control or protection for the wearer, the respiratory illness being evaluated, and (for controlled trials) what control group was used.
A Cochrane review (15) on physical interventions to interrupt or reduce the spread of respiratory viruses included 67 RCTs and observational studies. It found that “overall masks were the best performing intervention across populations, settings and threats.” There is a similar preprint review by the same lead author (16), in which only studies where mask wearing was tested as a stand-alone intervention were included, without combining it with hand hygiene and physical distancing, and excluding observational studies. That review concluded that “there was insufficient evidence to provide a recommendation on the use of facial barriers without other measures.” MacIntyre and Chughtai (17) published a review evaluating masks as protective intervention for the community, protection for health workers, and as source control. The authors conclude that “community mask use by well people could be beneficial, particularly for COVID-19, where transmission may be pre-symptomatic. The studies of masks as source control also suggest a benefit, and may be important during the COVID-19 pandemic in universal community face mask use as well as in health care settings.”
The Usher Institute incorporated laboratory as well as epidemiological evidence in their review (18), finding that “homemade masks worn by sick people can reduce virus transmission by mitigating aerosol dispersal. Homemade masks worn by sick people can also reduce transmission through droplets.” One preprint systematic review (19) including epidemiological, theoretical, experimental, and clinical evidence found that “face masks in a general population offered significant benefit in preventing the spread of respiratory viruses especially in the pandemic situation, but its utility is limited by inconsistent adherence to mask usage.” On the other hand, a preprint systematic review that only included RCTs and observational studies (20) concluded, based on the RCTs, that there was only weak evidence for a small effect from mask use in the community, but that the RCTs often suffered from poor compliance and controls. It found that, in observational studies, the evidence in favor of wearing face masks was stronger.
Randomized control trial evidence that investigated the impact of masks on household transmission during influenza epidemics indicates potential benefit. Suess et al. (21) conducted an RCT that suggests household transmission of influenza can be reduced by the use of nonpharmaceutical interventions, namely the use of face masks and intensified hand hygiene, when implemented early and used diligently. Concerns about acceptability and tolerability of the interventions should not be a reason against their recommendation (21). In an RCT, Cowling et al. (22) investigated hand hygiene and face masks that seemed to prevent household transmission of influenza virus when implemented within 36 h of index patient symptom onset. These findings suggest that nonpharmaceutical interventions are important for mitigation of pandemic and interpandemic influenza. RCT findings by Aiello et al. (23) “suggest that face masks and hand hygiene may reduce respiratory illnesses in shared living settings and mitigate the impact of the influenza A (H1N1) pandemic.” A randomized intervention trial (24) found that “face masks and hand hygiene combined may reduce the rate of ILI [influenza-like illness] and confirmed influenza in community settings. These nonpharmaceutical measures should be recommended in crowded settings at the start of an influenza pandemic.” The authors noted that their study “demonstrated a significant association between the combined use of face masks and hand hygiene and a substantially reduced incidence of ILI during a seasonal influenza outbreak. If masks and hand hygiene have similar impacts on primary incidence of infection with other seasonal and pandemic strains, particularly in crowded, community settings, then transmission of viruses between persons may be significantly decreased by these interventions.”
Overall, direct evidence of the efficacy of mask use is supportive, but inconclusive. Since there are no RCTs, only one observational trial, and unclear evidence from other respiratory illnesses, we will need to look at a wider body of evidence.

A Framework for Considering the Evidence​

The standard RCT paradigm is well suited to medical interventions in which a treatment has a measurable effect at the individual level and, furthermore, interventions and their outcomes are independent across persons comprising a target population.
By contrast, the effect of masks on a pandemic is a population-level outcome where individual-level interventions have an aggregate effect on their community as a system. Consider, for instance, the impact of source control: Its effect occurs to other individuals in the population, not the individual who implements the intervention by wearing a mask. This also underlies a common source of confusion: Most RCT studies in the field examine masks as personal protective equipment (PPE) because efficacy can be measured in individuals to whom treatment is applied, that is, “did the mask protect the person who wore it?” Even then, ethical issues prevent the availability of an unmasked control arm (25).
The lack of direct causal identifiability requires a more integrative systems view of efficacy. We need to consider first principles—transmission properties of the disease, controlled biophysical characterizations—alongside observational data, partially informative RCTs (primarily with respect to PPE), natural experiments (26), and policy implementation considerations—a discursive synthesis of interdisciplinary lines of evidence which are disparate by necessity (9, 27).
The goal of such an analysis is to assess the potential benefits and risks, in order to inform policy and behavior. United Nations Educational, Scientific and Cultural Organization states that “when human activities may lead to morally unacceptable harm that is scientifically plausible but uncertain, actions shall be taken to avoid or diminish that harm” (28). This is known as the “precautionary principle.” It was implemented in an international treaty in the 1987 Montreal Protocol. The loss of life and economic destruction that has been seen already from COVID-19 are “morally unacceptable harms.”
In order to identify whether public mask wearing is an appropriate policy, we need to consider the following questions, and assess, based on their answers, whether mask wearing is likely to diminish harm based on the precautionary principle: 1) What could the overall population-level impact of public mask wearing be (population impact)? 2) Based on our understanding of virus transmission, what would be required for a mask to be effective (transmission characteristics)? 3) Do face masks decrease the number of people infected by an infectious mask wearer (source control)? 4) Do face masks impact the probability of the wearer becoming infected themselves (PPE)? 5) Can masks lead to unintended benefits or harm, for example, risk compensation behavior (sociological considerations)? 6) How can medical supply chains be maintained (implementation consideration)? We will evaluate each consideration in turn.

Population Impact​

There are now over 100 countries that have implemented mask requirements (29), and many regions such as US states that have their own mask mandates. Most of these requirements were instituted after there was a shortage of medical masks, so results in these countries are likely to reflect the reality of what masks the public is able to access in practice during a pandemic. By analyzing the timing of pandemic spread and mask use, along with confounders such as population and geographic statistics, and timings of other policy interventions, it is possible to estimate the impact of mask use at a policy level. Here we look at studies based on this approach, as well as looking at estimated outcomes based on models, as part of a broad population impact analysis.

Ecological Studies.​

Leffler et al. (29) used a multiple regression approach, including a range of policy interventions and country and population characteristics, to infer the relationship between mask use and SARS-CoV-2 transmission. They found that transmission was 7.5 times higher in countries that did not have a mask mandate or universal mask use, a result similar to that found in an analogous study of fewer countries (30). Another study looked at the difference between US states with mask mandates and those without, and found that the daily growth rate was 2.0 percentage points lower in states with mask mandates, estimating that the mandates had prevented 230,000 to 450,000 COVID-19 cases by May 22, 2020 (31).
The approach of Leffler et al. (29) was replicated by Goldman Sachs for both US and international regions, finding that face masks have a large reduction effect on infections and fatalities, and estimating a potential impact on US GDP of 1 trillion dollars if a nationwide mask mandate were implemented (32). Although between-region comparisons do not allow for direct causal attribution, they suggest mask wearing to be a low-risk measure with a potentially large positive impact.
A paper in the American Journal of Respiratory and Critical Care Medicine (33) which analyzed Google Trends, E-commerce, and case data found that early public interest in face masks may be an independently important factor in controlling the COVID-19 epidemic on a population scale. Abaluck et al. (34) extend the between-country analyses from a cost perspective, estimating the marginal benefit per cloth mask worn to be in the range from US$3,000 to US$6,000.
A study of COVID-19 incidence in Hong Kong noted that face mask compliance was very high, at 95.7 to 97.2% across regions studied, and that COVID-19 clusters in recreational ‘mask-off’ settings were significantly more common than in workplace “mask-on” settings (35).

Modeling.​

At the national and global scale, effective local interventions are aggregated into epidemiological parameters of disease spread. The standard epidemiological measure of spread is known as the basic reproduction number R0R0 which provides parameters for the average number of people infected by one person, in a susceptible population with no interventions. The goal of any related health care policy is to have an aggregate effect of reducing the effective reproduction number ReRe to below 1. ReRe is the average number of people infected by one person in a population in practice, including the impact of policies, behavior change, and already infected people.
Efficacy of face masks within local interventions would have an aggregate effect on the reproduction number of the epidemic. In this section, we look at models that have attempted to estimate the possible magnitude of such an effect. The basic reproduction number R0R0 is estimated to be in the range 2.4 to 3.9 (36).
Stutt et al. (37) explain that it is impossible to get accurate experimental evidence for potential control interventions, but that this problem can be approached by using mathematical modeling tools to provide a framework to aid rational decision-making. They used two complementary modeling approaches to test the effectiveness of mask wearing. Their models show that mask use by the public could significantly reduce the rate of COVID-19 spread, prevent further disease waves, and allow less stringent lockdown measures. The effect is greatest when 100% of the public wear face masks. They found that, with a policy that all individuals must wear a mask all of the time, a median effective COVID-19 ReRe of below 1 could be reached, even with mask effectiveness of 50% (for R0R0 = 2.2) or of 75% (for R0R0 = 4).
Kai et al. (38) presented two models for predicting the impact of universal mask wearing. Both models showed a significant impact under (near) universal masking when at least 80% of a population is wearing masks, versus minimal impact when only 50% or less of the population is wearing masks. Their models estimated that 80 to 90% masking would eventually eliminate the disease. They also looked at an empirical dataset, finding a very strong correlation between early universal masking and successful suppression of daily case growth rates and/or reduction from peak daily case growth rates, as predicted by their theoretical simulations.
Tian et al. (39) developed a simple transmission model that incorporated mask wearing and mask efficacy as a factor in the model. For wearing masks, they found that wearing masks reduces ReRe by a factor (1−mp)2(1−mp)2, where m is the efficacy of trapping viral particles inside the mask, and p is the percentage of the population that wears masks. When combined with contact tracing, the two effects multiply. The paper notes that an important issue not treated explicitly is the role played by asymptomatic carriers of the virus. In addition, if adherence is socioeconomically, demographically, or geographically clustered, the mass action model may overestimate the impact. This is a limitation that could apply to all of the models discussed in this review.
Under the Tian et al. (39) model, the largest effects are seen when R0R0 is high, since the factor discussed above is a multiplier of R0R0. Therefore, we will consider a conservative assessment applied to an assumed R0R0 of 2.4, which is at the low end of the range presented above, and also supported by other studies (40). With 50% mask usage and 50% mask efficacy level, (1−mp)2=0.56(1−mp)2=0.56. Thus an R0R0 of 2.4 is reduced to an ReRe of 2.4×0.56=1.342.4×0.56=1.34, a huge impact rendering spread comparable to the reproduction number of seasonal influenza. To put this in perspective, 100 cases at the start of a month become 584 cases by the month’s end (Re=1.34Re=1.34) under these assumptions, versus 31,280 cases (Re=2.4Re=2.4) if masks are not used. Such a slowdown in caseload protects health care capacity and renders a local epidemic amenable to contact tracing interventions that could eliminate the spread entirely.
A full range of efficacy m and adherence p based on an R0R0 of 2.4 is shown with the resulting ReRe in Fig. 1, illustrating regimes in which growth is dramatically reduced (Re<1Re<1) as well as pessimistic regimes (e.g., due to poor implementation or population compliance) that nonetheless result in a beneficial effect in suppressing the exponential growth of the pandemic. For different values of R0R0, the image would be identical, with just the color bar scale varying linearly with the change in R0R0.
Impact of public mask wearing under the full range of mask adherence and efficacy scenarios. The color indicates the resulting reproduction number Re from an initial R0 of 2.4 (40). Blue area is what is needed to slow the spread of COVID-19. Each black line represents a specific disease transmission level with the effective reproduction number Re indicated.
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Fig. 1.
Impact of public mask wearing under the full range of mask adherence and efficacy scenarios. The color indicates the resulting reproduction number ReRe from an initial R0R0 of 2.4 (40). Blue area is what is needed to slow the spread of COVID-19. Each black line represents a specific disease transmission level with the effective reproduction number ReRe indicated.

Ngonghala et al. (41) use a similar approach, covering a wider variety of interventions, and completing numerous numerical simulations. They find that “high use of face-masks in public could lead to COVID-19 elimination,” and that “combining face-masks and social-distancing is more effective in COVID-19 control.” Yan et al. (42) provide an additional example of an incremental impact assessment of respiratory protective devices using an augmented variant of a traditional SIR (susceptible, infectious, or recovered) model in the context of influenza with N95 respirators. They showed that a sufficiently high adherence rate (∼80% of the population) resulted in the elimination of the outbreak with most respiratory protective devices. Fisman et al. (43) used a next-generation matrix approach to estimate the conditions under which masks would reduce the reproduction number of COVID-19 under a threshold of 1. Their results find that masks, even with suboptimal efficacy in both prevention of acquisition and transmission of infection, could substantially decrease the reproduction number ReRe if widely used.
The models presented in this section are only as accurate as their assumptions and parameters. Kai et al. (38) did compare their model’s predictions with empirical results, and, overall, the models presented here are consistent with each other, and consistent with the empirical findings in the previous section. However, simulations and similar models are simplifications of the real world, and cannot fully model all of the interactions and drivers of results in practice.
Overall, population-level studies of the impact of wearing masks suggest that mask use may have been an important driver of differences in SARS-CoV-2 outcomes in different regions. These outcomes are in line with models that predict substantial population level impacts of widespread mask use.

Transmission Characteristics​

We have seen that the efficacy of public mask wearing is largely supported by epidemiological and ecological data, as well as models. This could be due to masks filtering virus from an infected wearer, or protecting the wearer from infectious people around them, or both. In order to understand who should wear what kind of mask, and in what situations, we need an understanding of virus transmission.
Some COVID-19 patients are asymptomatic, and nearly all have a presymptomatic incubation period ranging from 2 d to 15 d, with a median length of 5.1 d (44). Patients may be most infectious when symptoms are mildest or not present (45, 46). This characteristic differentiates SARS-CoV-2 (COVID-19) from SARS-CoV, as replication is activated early in the upper respiratory tract (URT) (47). A study of temporal dynamics inferred that infectiousness started from 2.3 d before symptom onset and peaked at 0.7 d before symptom onset (36).
High viral titers of SARS-CoV-2 are reported in the saliva of COVID-19 patients. These titers have been highest at time of patient presentation, and viral levels are just as high in asymptomatic or presymptomatic patients, and occur predominantly in the URT (46, 47). Asymptomatic people seem to account for approximately 40 to 45% of SARS-CoV-2 infections (48). An analysis of SARS-CoV-2 viral load by patient age showed that viral loads of SARS-CoV-2 in children are similar to adults (49). Another paper showed no significant difference in saliva loads between mildly symptomatic and asymptomatic children. These findings support the contention that everyone, adults and children, should wear masks (50).
A consequence of these disease characteristics is that any successful policy intervention must properly address transmission due to infectious patients that display few or no symptoms and may not realize that they are infected. Because people with symptoms, including coughing and sneezing, are generally expected to stay home, our focus will be on other transmission vectors: speaking, breathing, and contact.
This topic has been subject to added confusion due to debates about whether these particles should be referred to as droplets or aerosols, with implications about their ability to remain suspended in air over time (51, 52). Inconsistent use of terminology about respiratory particles that can transmit this disease has led to confusion for scientists, the public health community, and the general public. For this paper, we adopt the definition by Milton (52) that incorporates findings from modern aerosol physics which suggest that particles much larger than the 5-μm boundary (a number that is sometimes cited by public health authorities as a droplet/aerosol cutoff) can remain suspended in air for many minutes or more, can waft around, and, of significant consequence for public health implications for this pandemic, accumulate depending on currents of air and ventilation status of the environment (52). We will thus refer to these respiratory emissions as “respiratory particles” with the understanding that these include particles that are transmitted through the air in a manner beyond the “ballistic trajectories” traditionally assumed of respiratory droplets and thus include aerosols that can remain suspended in the air (52). While determining an exact number is not necessary for purposes of this review, according to latest research informed by modern aerosol physics, 100 μm is considered the boundary between aerosols and droplets (52).
Normal speaking produces thousands of oral fluid particles (aerosols and droplets) between 1 μm and 500 μm (53), which can harbor respiratory pathogens, including SARS-CoV-2 (54). Many of these emissions will then evaporate and turn into aerosolized particles that are threefold to fivefold smaller, and can float for 10 min or more in the air (54⇓–56). Speech is known to emit up to an order of magnitude more particles than breathing (51, 57, 58).
A recent analysis has found that transmission through talking may be a key vector (59), with louder speech creating increasing quantities and sizes of particles, and a small fraction of individuals behaving as “speech superemitters,” releasing an order of magnitude more aerosols than their peers (53). Vuorinen et al. (60) concluded, with a high level of certainty, that a major part of particles of respiratory origin stay airborne for a long enough time for them to be inhaled. They noted that the number of particles produced by speaking is significant, especially as it is normally done continuously over a longer period (60). Prather et al. (61) stated that aerosol transmission of viruses must be acknowledged as a key factor leading to the spread of infectious respiratory diseases, and that SARS-CoV-2 is silently spreading in aerosols exhaled by highly contagious infected individuals with no symptoms. They noted that masks provide a critical barrier. The site of inhalation is also affected by the size of these particles, with the smallest particles (≤5μ≤5μm) able to reach into the respiratory bronchioles and alveoli in the lungs and medium-sized ones (up to 10 μm to 15 μm) able to deposit in the “the trachea and large intrathoracic airways” (52).
Aerosolized transmission dynamics are pathogen specific, due to pathogen-specific peak shedding and inactivation rates (62, 63). Studies suggest that vibration of the vocal folds contributes more to particle atomization and the production of particles that carry microorganisms (62). SARS-CoV-2 is present in exhaled breath (64), but it is not known to what degree this route is responsible for transmission. A study of influenza suggests that vocalization might be critical for creation of infection breath particles (65).
The ability of masks to filter particles depends on the particle size and trajectory, with smaller floating aerosols more challenging to filter than larger particles with momentum (66). Because speech produces more particles containing the SARS-CoV-2 virus, and because transmission of SARS-CoV-2 without symptoms is associated with URT shedding, where particles formed through vocalization are likely to contain the virus, we should be particularly cognizant of the role of speech particles in transmission (59). Speech particles lose their momentum and become much smaller shortly after ejection, which is likely to make them easier to filter by source control (as egress at the wearer) than by PPE (at ingress to an susceptible person). We will look at source control and PPE efficacy in turn.

Source Control​

In this section, we study whether a face mask (particularly cloth or other unfitted masks) is likely to decrease the number of people infected by an infectious mask wearer. The use of mask wearing by potentially infectious people is known as “source control.”
There are two main ways to physically test a mask: 1) have someone wearing it vocalize, such as breathe, talk or cough, or 2) synthetically simulate these actions using a spray mechanism, such as a nebulizer. Because human actions are complex and hard to simulate correctly, the first approach is preferred where possible. There are, in turn, two ways to analyze the results of this approach: 1) directly or indirectly measure the amount of respiratory particles of differing sizes, or 2) measure the amount of infectious particles.

Human Studies: Infectious Particles.​

There are currently no studies that measure the impact of any kind of mask on the amount of infectious SARS-CoV-2 particles from human actions. Other infections, however, have been studied. One of the most relevant papers (67) is one that compares the efficacy of surgical masks for source control for seasonal coronaviruses (NL63, OC43, 229E, and HKU1), influenza, and rhinovirus. With 10 participants, the masks were effective at blocking coronavirus particles of all sizes for every subject. However, masks were far less effective at blocking rhinovirus particles of any size, or of blocking small influenza particles. The results suggest that masks may have a significant role in source control for the current coronavirus outbreak. The study did not use COVID-19 patients, and it is not yet known whether SARS-CoV-2 behaves the same as these seasonal coronaviruses, which are of the same family.
In a pair of studies from 1962 to 1975, a portable isolation box was attached to an Andersen Sampler and used to measure orally expelled bacterial contaminants before and after masking. In one study, during talking, unmasked subjects expelled more than 5,000 contaminants per 5 cubic feet; 7.2% of the contaminants were associated with particles less than 4 μm in diameter (68). Cloth-masked subjects expelled an average of 19 contaminants per 5 cubic feet; 63% were less than 4 μm in diameter. So overall, over 99% of contaminants were filtered. The second study used the same experimental setup, but studied a wider range of mask designs, including a four-ply cotton mask. For each mask design, over 97% contaminant filtration was observed (69).
Johnson et al. (70) found that no influenza could be detected by RT-PCR on sample plates at 20 cm distance from coughing patients wearing masks, while it was detectable without mask for seven of the nine patients. Milton et al. (71) found surgical masks produced a 3.4-fold (95% CI: 1.8 to 6.3) reduction in viral copies in exhaled breath by 37 influenza patients. Vanden Driessche et al. (72) used an improved sampling method based on a controlled human aerosol model. By sampling a homogeneous mix of all of the air around the patient, the authors could also detect any aerosol that might leak around the edges of the mask. Among their six cystic fibrosis patients producing infected aerosol particles while coughing, the airborne Pseudomonas aeruginosa load was reduced by 88% when wearing a surgical mask compared with no mask. Wood et al. (73) found, for their 14 cystic fibrosis patients with high viable aerosol production during coughing, a reduction in aerosol P. aeruginosa concentration at 2 m from the source by using an N95 mask (94% reduction, P < 0.001), or surgical mask (94%, P < 0.001). Stockwell et al. (74) confirmed, in a similar P. aeruginosa aerosol cough study, that surgical masks are effective as source control. One study (75) found surgical masks to decrease transmission of tuberculosis by 56% when used as source control and measuring differences in guinea pig tuberculosis infections, and another found similar results for SARS-CoV-2 infections in hamsters, using a “mask curtain” (76).
Multiple simulation studies show the filtration effects of cloth masks relative to surgical masks. Generally available household materials had between a 58% and 94% filtration rate for 1-μm bacteria particles, whereas surgical masks filtered 96% of those particles (77). A tea cloth mask was found to filter 60% of particles between 0.02 μm and 1 μm, where surgical masks filtered 75% (78). Simulation studies generally use a 30 L/min or higher challenge aerosol, which is around about 3 to 6 times the ventilation of a human at rest or doing light work (77). As a result, simulation studies may underestimate the efficacy of the use of unfitted masks in the community in practice.

Human Studies: Aerosol and Droplet Filtration.​

Anfinrud et al. (59) used laser light scattering to sensitively detect the emission of particles of various sizes (including aerosols) while speaking. Their analysis showed that visible particles “expelled” in a forward direction with a homemade mask consisting of a washcloth attached with two rubber bands around the head remained very close to background levels in a laser scattering chamber, while significant levels were expelled when speaking without a mask.
There are no studies that have directly measured the filtration of smaller or lateral particles in this setting, although, using Schlieren imaging, it has been shown that all kinds of masks greatly limit the spread of the emission cloud (79), consistent with a fluid dynamic simulation that estimated this filtration level at 90% (80). Another study used a manikin and visible smoke to simulate coughing, and found that a stitched cloth mask was the most effective of the tested designs at source control, reducing the jet distance in all directions from 8 feet (with no mask) to 2.5 inches (81).
One possible benefit of masks for source control is that they can reduce surface transmission, by avoiding droplets settling on surfaces that may be touched by a susceptible person. However, contact through surfaces is not believed to be the main way SARS-CoV-2 spreads (82), and the risk of transmission through surfaces may be small (83).
In summary, there is laboratory-based evidence that household masks have filtration capacity in the relevant particle size range, as well as efficacy in blocking aerosols and droplets from the wearer (67). That is, these masks help people keep their emissions to themselves. A consideration is that face masks with valves do not capture respiratory particles as efficiently, bypassing the filtration mechanism, and therefore offer less source control (84).

PPE​

In this section, we study whether a face mask is likely to decrease the chance of a potentially susceptible mask wearer becoming infected. The use of mask wearing by potentially susceptible people is known as “PPE.” Protection of the wearer is more challenging than source control, since the particles of interest are smaller. It is also much harder to directly test mask efficacy for PPE using a human subject, so simulations must be used instead. Masks can be made of different materials and designs (66) which influence their filtering capability.
There are two considerations when looking at efficacy: 1) the filtration of the material and 2) the fit of the design. There are many standards around the world for both of these issues, such as the US National Institute for Occupational Safety and Health (NIOSH) N95 classification. The “95” designation means that, when subjected to testing, the respirator blocks at least 95% of very small (0.3 μm) test particles. NIOSH tests at flow rates of 85 L/min, simulating a high work rate, which is an order of magnitude higher than rest or low-intensity breathing. These are designed to be tests of the worst case (i.e., it produces maximum filter penetration), because the test conditions are the most severe that are likely to be encountered in a work environment (85). These tests use particles that are much smaller than virus-carrying emissions, at much higher flow rates than normally seen in community settings, which means that masks that do not meet this standard may be effective as PPE in the community. The machines used for these studies are specifically designed for looking at respirators that hold their shape, which are glued or attached with beeswax firmly to the testing plate. Flexible masks such as cloth and surgical masks can get pulled into the hole in the testing plate, which makes it a less suitable testing method for these designs.
A study of filtration using the NIOSH approach (86), but with 78-nm particles, was used as the basis for a table in World Health Organization’s “Advice on the use of masks in the context of COVID-19” (87). There was over 90% penetration for all cotton masks and handkerchiefs, and 50 to 60% penetration for surgical masks and nonwoven nonmedical masks. Zhao et al. (88) used a similar approach, but at a lower 32 L/min (which is still 3 to 6 times higher than human ventilation during light work). They also tested materials after creating a triboelectric effect by rubbing the material with a latex glove for 30 s, finding that polyester achieved a quality factor (Q) of 40 kP/a, nearly 10 times higher than a surgical mask. Without triboelectric charging, it achieved a Q of 6.8, which was similar to a cotton t-shirt. They concluded that cotton, polyester, and polypropylene multilayered structures can meet or even exceed the efficiency of materials used in some medical face masks. However, it depends on the details of the material and treatment.
One recent study looked at the aerosol filtration efficiency of common fabrics used in respiratory cloth masks, finding that efficacy varied widely, from 12 to 99.9%, at flow rates lower than at-rest respiration (89). Many materials had ≥96% filtration efficacy for particles of >0.3 μm, including 600 threads per inch cotton, cotton quilt, and cotton layered with chiffon, silk, or flannel. A combination of materials was more effective than the materials on their own. These findings support studies reported in 1926 by Wu Lien Teh (4), which described that a silk face covering with flannel added over the mouth and nose was highly effective against pneumonic plague.
There are many designs of cloth masks, with widely varying levels of fit. There have been few tests of different designs. A simple mask cut from a t-shirt achieved a fit score of 67, offering substantial protection from the challenge aerosol and showing good fit with minimal leakage (90). One study looked at unfitted surgical masks, and used three rubber bands and a paper clip to improve their fit (91). All 11 subjects in the test passed the N95 fit test using this approach. Wu Lien Teh noted that a rubber support could provide good fit, although he recommended that a silk covering for the whole head (and flannel sewed over nose and mouth areas), with holes for the eyes, tucked into the shirt, is a more comfortable approach that can provide good protection for a whole day (4).
Research focused on aerosol exposure has found all types of masks are at least somewhat effective at protecting the wearer. Van der Sande et al. (78) found that “all types of masks reduced aerosol exposure, relatively stable over time, unaffected by duration of wear or type of activity,” and concluded that “any type of general mask use is likely to decrease viral exposure and infection risk on a population level, despite imperfect fit and imperfect adherence.”
The review from Chu et al. (11) included three observational studies of face mask use for SARS-CoV-2 in health care environments, all showing a risk ratio of 0.03 to 0.04. However, these studies were given a much lower weight in the review than studies of Middle East respiratory syndrome and SARS, and the overall risk ratio for mask use in health care was estimated at 0.30.
One of the most frequently mentioned, but misinterpreted, papers evaluating cloth masks as PPE for health care workers is one from MacIntyre et al. (25). The study compared a “surgical mask” group, which received two new masks per day, to a “cloth mask” group that received five masks for the entire 4-wk period and were required to wear the masks all day, to a “control group,” which used masks in compliance with existing hospital protocols, which the authors describe as a “very high level of mask use.” There was not a “no mask” control group because it was deemed “unethical.” The study does not inform policy pertaining to public mask wearing as compared to the absence of masks in a community setting. They found that the group with a regular supply of new surgical masks each day had significantly lower infection of rhinovirus than the group that wore a limited supply of cloth masks, consistent with other studies that show surgical masks provide poor filtration for rhinovirus, compared to seasonal coronaviruses (67).
Most of the research on masks as health worker PPE focuses on influenza, though it is not yet known to what extent findings from influenza studies apply to COVID-19 filtration. Wilkes et al. (92) found that “filtration performance of pleated hydrophobic membrane filters was demonstrated to be markedly greater than that of electrostatic filters.” A metaanalysis of N95 respirators compared to surgical masks (93) found “the use of N95 respirators compared with surgical masks is not associated with a lower risk of laboratory-confirmed influenza.” Radonovich et al. (94) found, in an outpatient setting, that “use of N95 respirators, compared with medical masks in the outpatient setting resulted in no significant difference in the rates of laboratory-confirmed influenza.”
One possible additional benefit of masks as PPE is that they do not allow hands to directly touch the nose and mouth, which may be a transmission vector. The lipid barrier that protects viruses is destroyed within 5 min of touching the hands (95), and wearing a mask during that period could be protective. However, there are no case reports or laboratory evidence to suggest that touching the mask can cause infection.
Overall, it appears that cloth face covers can provide good fit and filtration for PPE in some community contexts, but results will vary depending on material and design, the way they are used, and the setting in which they are used.

Sociological Considerations​

Some of the concerns about public mask wearing have not been around primary evidence for the efficacy of source control, but concerns about how they will be used.

Risk Compensation Behavior.​

One concern around public health messaging promoting the use of face covering has been that members of the public may use risk compensation behavior. This involves fear that the public would neglect other measures like physical distancing and hand hygiene, based on overvaluing the protection a mask may offer due to an exaggerated or false sense of security (96). Similar arguments have previously been made for HIV prevention strategies (97, 98), motorcycle helmet laws (99), seat belts (100), and alpine skiing helmets (101). However, contrary to predictions, risk compensation behaviors have not been significant at a population level, being outweighed by increased safety in each case (100, 102⇓⇓–105). These findings strongly suggest that, instead of withholding a preventative tool, accompanying it with accurate messaging that combines different preventative measures would display trust in the general public’s ability to act responsibly and empower citizens. Polling and observational data from the COVID-19 pandemic have shown mask wearing to be positively correlated with other preventative measures, including hand hygiene (106, 107), physical distancing (106, 107), and reduced face touching (108). Three preprint papers reporting observational data suggest that masks may be a cue for others to keep a wider physical distance. (109⇓–111).

Managing the Stigma Associated with Wearing a Mask.​

Stigma is a powerful force in human societies, and many illnesses come with stigma for the sick as well as fear of them. Managing the stigma is an important part of the process of controlling epidemics (112). Tuberculosis is an example of an illness where masks are used as source control but became a public label associated with the disease. Many sick people are reluctant to wear a mask if it identifies them as sick, in an effort to avoid the stigma of illness (113, 114). Some health authorities have recommended wearing masks for COVID-19 only if people are sick; however, reports of people wearing masks being attacked, shunned, and stigmatized have also been observed (115). In many countries, minorities suffer additional stigma and assumptions of criminality (116). Black people in the United States have reportedly been reluctant to wear masks in public during this pandemic for fear of being mistaken for criminals (117, 118). Thus, it may not even be possible to have sick people alone wear masks, due to stigma, employer restrictions, or simple lack of knowledge of one’s status, without mask wearing becoming universal policy.

Creating New Symbolism around Wearing a Mask.​

Ritual and solidarity are important in human societies and can combine with visible signals to shape new societal behaviors (119, 120). Universal mask wearing could serve as a visible signal and reminder of the pandemic. Signaling participation in health behaviors by wearing a mask as well as visible enforcement can increase compliance with public mask wearing, but also other important preventative behaviors (121). Historically, epidemics are a time of fear, confusion, and helplessness (122, 123). Mask wearing, and even mask making or distribution, can provide feelings of empowerment and self-efficacy (124). Health is a form of public good in that everyone else’s health behaviors improve the health odds of everyone else (125, 126). This can make masks symbols of altruism and solidarity (127). Viewing masks as a social practice, governed by sociocultural norms, instead of a medical intervention, has also been proposed to enhance longer-term uptake (128).

Implementation Considerations​

Globally, health authorities have followed different trajectories in recommendations around the use of face masks by the public. In China, Taiwan, Japan, and South Korea, face masks were utilized from the start of the pandemic (2). Other countries, like Czechia and Thailand, were early adopters in a global shift toward recommending cloth masks. We present considerations for the translation of evidence about public mask wearing to diverse countries across the globe, outside of the parameters of a controlled research setting.

Supply Chain Management of N95 Respirators and Surgical Masks.​

There has been a global shortage of protective equipment for health workers, with health workers falling ill and dying of COVID-19 (129). N95 respirators are recommended for health workers conducting aerosol-generating procedures during clinical care of COVID-19 patients, while surgical masks are recommended otherwise (130). Strategies to manage the shortage of PPE have included sterilization and reuse of respirators, and appeals to the public to reduce their use of medical masks (131). There were early concerns that public messaging encouraging mask use will deplete critical supplies. Some regions, like South Korea and Taiwan, have combined recommendations for the public to use surgical masks with rapidly increasing production of surgical masks, while, in other regions, cloth masks are promoted as alternative to surgical masks as source control. Cloth masks offer additional sustainability benefits through reuse, thus limiting costs and reducing environmental waste.
There is some literature suggesting that face shields could provide additional eye protection along with better visibility of facial expressions and fewer obstacles for communities, such as people who rely on lip reading for communication (132). However, face shields alone have a large escape through brow and downjets (79), which may make them less effective for source control, and this remains an open research question.

Mandatory Mask Wearing.​

Ensuring compliance with nonpharmaceutical interventions can be challenging, but likely rapidly increases during a pandemic (133). Perceptions of risk play an important role in mask use (14). Telephone surveys during the SARS-CoV-2 outbreak in Hong Kong reported enhanced adherence to public mask wearing as the pandemic progressed over 3 wk, with 74.5% self-reported mask wearing when going out increasing to 97.5%, without mandatory requirements (5). Similar surveys reported face mask use in Hong Kong during the SARS outbreak in 2003 as 79% (134), and approximately 10% during the influenza A (H1N1) pandemic in 2009 (135). This suggests that the public have enhanced awareness of their risk, and that they display higher adherence levels to prevention strategies than during other epidemics. During the COVID-19 pandemic, many countries have utilized mask mandates as implementation strategy. In Germany, implementing a mask mandate led to well-documented, widespread uptake in the use of masks. (106) A preregistered experiment (n = 925) further showed that “a voluntary policy would likely lead to insufficient compliance, would be perceived as less fair, and could intensify stigmatization. A mandatory policy appears to be an effective, fair, and socially responsible solution to curb transmissions of airborne viruses.” Although the use of mandates has been a polarizing measure, it appears to be highly effective in shaping new societal norms.
Modeling suggests (38, 39) that population-level compliance with public mask wearing of 70% combined with contact tracing would be critical to halt epidemic growth. Population-level uptake of an intervention to benefit the whole population is similar to vaccinations. A common policy response to this conundrum is to ensure compliance by using laws and regulations, such as widespread state laws in the United States which require that students have vaccinations to attend school. Research shows that the strength of the mandate to vaccinate greatly influences compliance rates for vaccines and that policies that set a higher bar for vaccine exemptions result in higher vaccination rates (136). The same approach is now being used in many jurisdictions to increase mask wearing compliance, by mandating mask use in a variety of settings (such as public transportation or grocery stores or even at all times outside the home). Population analysis suggests that these laws are effective at increasing compliance and slowing the spread of COVID-19 (29, 31, 32).

Further Research​

There are many important issues that need to be addressed. In this section, we suggest further research directions.
There is a need to understand how masks can be used throughout the day, by both children (at school) (50) and adults (at work). In a study of the effect of mask use on household transmission of SARS-CoV-2, masks were found to be highly effective, including for children, and the secondary attack rate for children was found to be only half that of adults. However, the impact of masks on children was not compared to adults (10). Some researchers have proposed that face shields may be appropriate in some environments (132), but it has not been well studied. Research on the efficacy of face shields, including in combination with masks, is needed, along with research into the efficacy of masks with transparent windows for the mouth.
The impact of using masks to control transmission in the workplace has not been well studied. One issue that impacts both school and work usage is that, over a full day’s use, masks may become wet, or dirty. A study of mask use in health care settings found that “respiratory pathogens on the outer surface of the used medical masks may result in self-contamination,” and noted that “the risk is higher with longer duration of mask use (>6h) and with higher rates of clinical contact” (137). Further research is needed to clarify these issues. In the meantime, most health bodies recommend replacing dirty or wet masks with clean ones.
Overall, our understanding of the relative merits of different cloth mask designs and materials is still limited. The silk head covering with cotton sewn over mouth and nose used 100 y ago by Wu Lien Teh (4) aligns with recent findings on the use of silk-cotton combinations (89) and approaches to avoid lateral and brow jets (79, 81). Wu also noted the potential of improving fit by using a rubber overlay, which has also been rediscovered recently (91). However, there are no modern studies of the efficacy of a full range of mask designs and material combinations, using the most relevant flow rates (at rest or low exertion rate of 15 L/min), and contexts (exhalation from a real person, or simulation using a manikin). Novel approaches to materials, such as using two enveloped layers of paper towel aligned at right angles (138), paper towel combined with a face shield (139), and polyvinylidene difluoride nanofibers (140) have not been well studied in the English language literature.

Conclusion​

Our review of the literature offers evidence in favor of widespread mask use as source control to reduce community transmission: Nonmedical masks use materials that obstruct particles of the necessary size; people are most infectious in the initial period postinfection, where it is common to have few or no symptoms (45, 46, 141); nonmedical masks have been effective in reducing transmission of respiratory viruses; and places and time periods where mask usage is required or widespread have shown substantially lower community transmission.
The available evidence suggests that near-universal adoption of nonmedical masks when out in public, in combination with complementary public health measures, could successfully reduce ReRe to below 1, thereby reducing community spread if such measures are sustained. Economic analysis suggests that mask wearing mandates could add 1 trillion dollars to the US GDP (32, 34).
Models suggest that public mask wearing is most effective at reducing spread of the virus when compliance is high (39). We recommend that mask use requirements are implemented by governments, or, when governments do not, by organizations that provide public-facing services. Such mandates must be accompanied by measures to ensure access to masks, possibly including distribution and rationing mechanisms so that they do not become discriminatory. Given the value of the source control principle, especially for presymptomatic people, it is not sufficient for only employees to wear masks; customers must wear masks as well.
It is also important for health authorities to provide clear guidelines for the production, use, and sanitization or reuse of face masks, and consider their distribution as shortages allow. Clear and implementable guidelines can help increase compliance, and bring communities closer to the goal of reducing and ultimately stopping the spread of COVID-19.
When used in conjunction with widespread testing, contact tracing, quarantining of anyone that may be infected, hand washing, and physical distancing, face masks are a valuable tool to reduce community transmission. All of these measures, through their effect on ReRe, have the potential to reduce the number of infections. As governments exit lockdowns, keeping transmissions low enough to preserve health care capacity will be critical until a vaccine can be developed.