What Is Ocular Monkeypox? CDC Reports 5 Cases Of The Eye-Related Infection

[SBFNews]

What Is Ocular Monkeypox? CDC Reports 5 Cases Of The Eye-Related Infection​

Oct 19, 2022 05:38 AM
By Athena Chan

www.medicaldaily.com

Authorities have reported five cases of ocular monkeypox in the U.S. amid the 2022 outbreak. People who get monkeypox may get this eye-related complication, which can even lead to vision impairment.

The U.S. Centers for Disease Control and Prevention (CDC) reported the cases in its Morbidity and Mortality Weekly Report (MMWR) Monday. The five cases of ocular monkeypox were logged from July to September this year. Among them, two had HIV-associated immunocompromise.

According to the CDC, ocular monkeypox is defined as the "presence of new ocular disease compatible with Orthopoxvirus (OPXV) infection in a patient with probable or confirmed monkeypox," and there is no other explanation for the ocular condition.

A monkeypox virus infection may affect "vulnerable" parts of the body, including the eyes, the agency explained. This can happen if the virus is introduced to the eye, which can then be "debilitating" for a patient with a monkeypox infection.

Resulting problems may range from mild to severe and cause conditions such as corneal ulcer, keratitis, conjunctivitis, corneal scarring, or, albeit "rarely," vision loss.
"Corneal scarring and vision loss are potential severe consequences of ocular involvement of Monkeypox virus infection," the CDC noted. "Bacterial superinfection of corneal ulcerations can cause severe complications."

In a 2014 study of monkeypox infections in the Democratic Republic of Congo, for instance, 23% of the patients reportedly had conjunctivitis, according to the CDC. In the current outbreak, however, it has been rather "uncommon," with only less than 1% of the cases showing eye-related symptoms.

That said, the agency is urging healthcare providers to be aware of this potential manifestation of monkeypox infection, calling it a "sight-threatening condition."

For instance, one of the patients, described only as Patient A, presented a "progressive rash" and symptoms on the left eye such as swelling, itching and photosensitivity. Days later, the patient was admitted to the hospital because of "worsening ocular symptoms," with the left eye having conjunctivitis. At the time, the patient's visual acuity was at 20/40, which is still quite close to the "standard" 20/20 vision.

The patient was discharged after five days but was readmitted weeks later because of new lesions and worsening vision in the left eye, which at the time already had an acuity of 20/300. He also had keratitis, conjunctivitis and conjunctival ulcer.

As of the posting of the CDC report, the patient was still at the hospital with "waxing and waning" pain in the left eye. The most recent visual acuity measurement was at 20/800, which the CDC described as a "profound visual impairment." In the U.S., visual acuity of 20/200 can be considered "legally blind."

"All five patients with ocular monkeypox described in this report suffered prolonged illness, four were hospitalized, and one experienced significant vision impairment," the CDC noted.

The agency is advising healthcare providers to consider "urgent ophthalmic evaluation" and treatment if a patient with monkeypox presents ocular symptoms so as to prevent poor outcomes for their eyesight.

As for the patients themselves, they are being advised to practice good hand hygiene and avoid touching their eyes. It would also be best to stop using contact lenses for the time being.

"Public health officials should be promptly notified of cases of ocular monkeypox," the CDC said. "Increased clinician awareness of ocular monkeypox and of approaches to prevention, diagnosis, and treatment might reduce associated morbidity."

 

[SBFNews]

https://www.aao.org/eye-health/tips-prevention/monkeypox-eyes-conjunctivitis-pinkeye

Monkeypox and Pink Eye (Conjunctivitis): When to Call a Doctor​

By Anni Delfaro
Reviewed By Steven Yeh MD, Christopher E Starr MD, Jessica G Shantha, MD

Aug. 26, 2022

Monkeypox cases swept the globe in 2022, spilling out of historically endemic areas in West and Central Africa. By July, cases had been confirmed on every continent except Antarctica and the World Health Organization declared the outbreak a Public Health Emergency of International Concern.

Past reports warn that monkeypox may cause eye problems ranging from pink eye (conjunctivitis) to vision loss from corneal scarring. But how common are these complications and what should patients watch for?

Ophthalmologists offer advice on monkeypox eye symptoms, home remedies and when to call a doctor.

What is monkeypox?​

Monkeypox is a virus that is closely related to smallpox, but far less deadly and contagious.

This virus is not new. Monkeypox was first identified in 1958 in monkeys transported to Denmark for scientific research, but scientists suspect it’s been circulating for thousands of years. Interestingly, it has only once been identified in a wild monkey; it’s far more common in rodents.

The first human case of monkeypox was reported in 1970 and, until now, most human cases have occurred in West and Central Africa.

General symptoms of monkeypox​

Most people with monkeypox develop symptoms 1 to 3 weeks after close contact with an infected person. In general, these may include:

• A painful or itchy rash. Blisters or pimples may erupt on the face, genitals, chest, hands or feet. This rash can take a few weeks to disappear.
• Flu-like symptoms, such as a fever, headache or congestion.

If you develop these symptoms, ask your doctor about testing and treatment for the virus.

“While the monkeypox rash can have a characteristic appearance, it shares some similarities with other infections such as syphilis, herpes simplex and varicella zoster virus (the cause of shingles and chickenpox) and may require additional lab testing,” says Steven Yeh, MD, an ophthalmologist and expert in ocular infectious disease.

How does monkeypox get into the eyes?​

It’s very common for people with monkeypox to develop a rash on the face. This increases the risk of eye problems.

“Watch for lesions around the skin of the eye,” advises Dr. Yeh, whose clinic cares for patients referred from the United States as well as several countries in sub-Saharan Africa, including Sierra Leone and the Democratic Republic of Congo.

Avoid touching your face or rubbing your eyes – especially if you have blisters on or near your eyelids. Doing so can increase your risk of pink eye (conjunctivitis) or other monkeypox-related eye problems.

Monkeypox can cause pink eye, or conjunctivitis​

Most of what we know about monkeypox-related eye problems comes from studies of past outbreaks in Africa. Those reports warned that as many as 30% of people with monkeypox experience pink eye, or conjunctivitis.

But pink eye has been far less common in the 2022 outbreak. A recent study of 528 people infected with monkeypox between May and June 2022 found that only 3 developed conjunctivitis.

It’s possible that symptoms may differ – or new ones may emerge – during the current outbreak, since it has expanded to new places and populations. “We are seeing a spectrum of disease that was not reported or detailed in prior outbreaks,” says Dr. Yeh.

So far, people infected during the 2022 monkeypox outbreak have developed eye problems such as:

• Eye redness or crusting
• Swelling or puffiness of the eyelids
• Blisters on or near the eyelids
• Light sensitivity (photophobia)
• Eye pain
• Blurred vision

Infected people who have been vaccinated against smallpox or monkeypox have a relatively low risk of developing these eye problems.

Can monkeypox cause blindness?​

The virus rarely causes serious vision-threatening problems, says Academy member and ophthalmologist Christopher Starr, MD, who practices at the Weill Cornell Medical Center on the Upper East Side of Manhattan in New York City, a monkeypox hot spot.

“While monkeypox cases are rising rapidly in the city, serious ocular manifestations are thankfully very rare,” says Dr. Starr. He and his colleagues have treated several patients with monkeypox, but so far none have developed problems in the eyes.

Ophthalmologists in the San Francisco Bay Area, another monkeypox hot spot, agree that eye complications have been rare in the current outbreak. "I have yet not heard about or seen any cases of moneypox-associated conjunctivitis," says ophthalmologist and Academy member Jessica Shantha, MD, who treats patients at the University of California at San Francisco.

According to a new entry in the Academy’s EyeWiki, serious eye complications can include an infection of the cornea that could lead to vision loss. Most reports of vision-threatening eye complications occurred during previous outbreaks in Africa.

“My sense is that ocular manifestations are not common, and when present are generally mild and not sight threatening,” Dr. Starr says. “While permanent blindness has been reported, this is an extremely rare complication.”

Should you treat monkeypox-related pink eye and other eye symptoms at home?​

If you develop eye pain or decreased vision, contact an ophthalmologist as soon as possible. The FDA has not approved any eye medications specific to monkeypox, but doctors may use antiviral medications, antibiotics or anti-inflammatory drugs to treat serious eye problems.

If you have mild eye symptoms without pain or blurred vision, try these home remedies:

• Over-the-counter lubricating eye drops, also called artificial tears, may help alleviate some of the eye irritation and redness caused by monkeypox. Refrigerating the drops may further soothe the eyes.
• If you have eyelid swelling, try applying cold compresses to the closed eye. Be sure to disinfect the compress after use so that it will not spread the infection to other people in your household.
• Avoid wearing contact lenses. Use a new pair once you have fully recovered.
• Stop wearing eye makeup until your eyes have healed.
• Try these additional home remedies for pink eye.

 

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