It will Also be the end of Lebanon.
Right now, except for border with Jordan and Egypt where the gomen remains in charge, Israel borders with what I would define as broken states where gomen have no control over the insurgents or private militias. Entire northern Israeli border is exposed to this threat.
Assuming Israel uses nukes, it would be the start of a nuclear war with Pakistan providing the warhead.
Unless, with US which had just deposed of a elected prime minister of pakistan, can successfully control it's new military regime.