Small pharma Receives U.S. Patent for Lung Treatment Using ATYR1923

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https://www.tipranks.com/news/atyr-receives-u-s-patent-for-lung-treatment-using-atyr1923/

aTyr Receives U.S. Patent for Lung Treatment Using ATYR1923​

Jul 30, 2021, 09:00 PM
AA

 

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Shares of aTyr Pharma (LIFE) rose almost 4% in Thursday’s extended trading session after receiving a patent from the U.S. Patent and Trademark Office (USPTO).

aTyr Pharma is a biotherapeutics company focused on the research and development of innovative medicines based on novel biological pathways

The patent covers the company’s processes for the use of histidyl-tRNA synthetase Fc fusion proteins in reducing inflammatory responses in the lung. Notably, the patent covers the use of the company’s lead therapeutic product, ATYR1923.

ATYR1923 is an Fc fusion protein based on the N terminal fragment of histidyl-tRNA synthetase. It is currently undergoing clinical trials for the treatment of pulmonary sarcoidosis and is being evaluated in other inflammatory lung diseases, the company said.

Reacting positively to the news, aTyr CEO Sanjay S. Shukla said, “We are pleased with the USPTO grant of this patent covering the use of ATYR1923 to treat inflammatory response in the lung, which builds upon our growing intellectual property estate on this lead molecule series.” (See aTyr stock charts on TipRanks)

 

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Last month, Laidlaw analyst Yale Jenhosted a KOL call with the Pulmonary Medicine Chairperson from the Cleveland Clinic. During the call, the need for the treatment of pulmonary sarcoidosis (PS) and how the disease progresses, were highlighted. According to the expert, the cumulative risk of metabolic complications due to the long-term use of glucocorticosteroids stands as the major unmet need. Therefore, the analyst stated that “aTyr has a therapy, ATYR1923, in PS with Phase II trial data on-track for 3Q21.”

According to Jen, besides an accurate safety profile, if ATYR1923 is successful in reducing steroid usage versus the placebo group, along with managing symptoms, including shortness of breath or coughing, it would be a catalyst for aTyr.

The analyst maintained a Buy rating and a price target of $18 (293% upside potential) on the stock “to reflect the potential success of the two first-in-class novel cancer therapeutics.”

“With multiple major catalysts within the next 12 months,” he believes “LIFE shares remain undervalued.”

Consensus among analysts is a Strong Buy based on 4 unanimous Buys. The average aTyr price targetstands at $14 and implies upside potential of 205.7% to current levels. Shares have gained 12.8% over the past year.

 

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Investors should always be aware of the risks involved in any stock. According to the new TipRanks’ Risk Factors tool, LIFE stock is at risk mainly from two factors: Tech & Innovation, and Finance and Corporate, which contribute 41% and 24%, respectively to the total risk for the stock. Within the Tech & Innovation risk category, aTyr has identified 27 individual risks.

 

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ATYR1923 is an Fc fusion protein based on the N terminal fragment of histidyl-tRNA synthetase. It is currently undergoing clinical trials for the treatment of pulmonary sarcoidosis and is being evaluated in other inflammatory lung diseases, the company said

What is pulmonary sarcoidosis?​

Sarcoidosis is a rare disease caused by inflammation. It usually occurs in the lungs and lymph nodes, but it can occur in almost any organ.

Sarcoidosis in the lungs is called pulmonary sarcoidosis. It causes small lumps of inflammatory cells in the lungs. These lumps are called granulomas and can affect how the lungs work. The granulomas generally heal and disappear on their own. But, if they don’t heal, the lung tissue can remain inflamed and become scarred and stiff. This is called pulmonary fibrosis. It changes the structure of the lungs and can affect your breathing. Bronchiectasis can also occur. This is when pockets form in the air tubes of the lung and become infected. But, these problems are not common.

https://www.hopkinsmedicine.org/health/conditions-and-diseases/pulmonary-sarcoidosis

 

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What is pulmonary sarcoidosis?​

Sarcoidosis is a rare disease caused by inflammation. It usually occurs in the lungs and lymph nodes, but it can occur in almost any organ.

Sarcoidosis in the lungs is called pulmonary sarcoidosis. It causes small lumps of inflammatory cells in the lungs. These lumps are called granulomas and can affect how the lungs work. The granulomas generally heal and disappear on their own. But, if they don’t heal, the lung tissue can remain inflamed and become scarred and stiff. This is called pulmonary fibrosis. It changes the structure of the lungs and can affect your breathing. Bronchiectasis can also occur. This is when pockets form in the air tubes of the lung and become infected. But, these problems are not common.

https://www.hopkinsmedicine.org/health/conditions-and-diseases/pulmonary-sarcoidosis

Key points about pulmonary sarcoidosis​

• Sarcoidosis is caused by inflammation. Most cases of sarcoidosis are found in the lungs and lymph nodes, but it can occur in almost any organ.
• Sarcoidosis in the lungs is called pulmonary sarcoidosis. It causes small lumps of inflammatory cells, called granulomas, in the lungs. They can affect how the lungs work.
• The cause of pulmonary sarcoidosis is unknown.
• The most common symptoms of pulmonary sarcoidosis are shortness of breath, which often gets worse with activity; dry cough that will not go away; chest pain; and wheezing.
• Treatment is generally done to control symptoms or to improve the function of organs affected by the disease. Steroids are often used.

 

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What causes pulmonary sarcoidosis?​

The cause of pulmonary sarcoidosis is unknown. Experts think that bacteria, viruses, or chemicals might trigger the disease. It may also be genetic. This means a person is more likely to develop sarcoidosis if someone his or her close family has it. This is an active area of research.

 

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What are the symptoms of pulmonary sarcoidosis?​

Most people with sarcoidosis do not have symptoms and probably don't know they have the disease. It can affect many organs, causing a variety of symptoms. Pulmonary sarcoidosis can reduce the amount of air the lungs can hold and cause lung stiffness.

The following are the most common symptoms of pulmonary sarcoidosis. However, each person may experience symptoms differently. Symptoms may include:

• Shortness of breath, which often gets worse with activity
• Dry cough that will not go away
• Chest pain
• Wheezing

Sarcoidosis can also cause symptoms not directly related to the lungs, such as:

• Extreme tiredness
• Fever
• Inflammation of the eyes and pain, burning, blurred vision, and light sensitivity
• Night sweats
• Pain in the joints and bones
• Skin rashes, lumps, and color changes on face, arms, or shins
• Swollen lymph nodes
• Weight loss

The symptoms of pulmonary sarcoidosis may look like other conditions or medical problems. Talk with your healthcare provider for a diagnosis.

 

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How is pulmonary sarcoidosis diagnosed?​

In addition to a complete medical history and physical exam, tests used may include:

• Chest X-ray. A type of imaging test used to assess the lungs, as well as the heart. Chest X-rays may show important information about the size, shape, and location of the lungs, bronchi (large breathing tubes), and mediastinum (area in the middle of the chest separating the lungs).
• CT scan. An imaging test that uses X-rays and computer technology to produce horizontal, or axial, images or slices of the body. A CT scan shows detailed images of any part of the body, including the lungs. CT scans are more detailed than regular X-rays. They can be used to diagnose lung diseases, monitor disease progression, and evaluate response to treatment.
• Pulmonary function tests. These are tests that help to measure the lungs' ability to move air in and out of the lungs. The tests are usually done with special machines into which the person must breathe.
• Blood tests. These can be used to check the amount of carbon dioxide and oxygen in the blood, evaluate liver and kidney function, and look for infection and other diseases.
• Bronchoscopy. A long, thin, flexible tube with a light at the end is put down the throat and into the lungs. This lets the doctor to view the bronchi, the main airways of the lungs. It is done to help evaluate and diagnose lung problems. Lung tissue samples (biopsies) and lung washings (lavage) that remove cells from the lungs can be done through the bronchoscope.
• Bronchoalveolar lavage. This is a procedure in which a sterile saline solution is put into the lungs through a bronchoscope and then suctioned out. The saline carries out cells from the lower respiratory tract, which can be checked under a microscope to help identify inflammation and infection. It can help rule out certain causes.
• Lung biopsy. A test in which a small piece of tissue, cells, or fluid from the lungs is taken out and checked under a microscope.

Sarcoidosis is usually diagnosed when other lung disorders are ruled out.

 

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How is pulmonary sarcoidosis treated?​

Treatment is generally done to control symptoms and improve the function of organs affected by the disease. Steroid medicine, such as prednisone, may help reduce inflammation. It can be taken by mouth or inhaled. Other medicines, such as methotrexate, may be used in severe cases or if steroids don’t work.

In many cases, no treatment is needed for pulmonary sarcoidosis. Different treatments work better for different people. Sometimes more than one treatment is used. Most medicines used to treat sarcoidosis suppress the immune system.

You may also join a rehab program that includes education, exercise, and support. In severe cases, which are not common, oxygen therapy and even lung transplant may be needed.

 

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Next steps​

Tips to help you get the most from a visit to your healthcare provider:

• Know the reason for your visit and what you want to happen.
• Before your visit, write down questions you want answered.
• Bring someone with you to help you ask questions and remember what your healthcare provider tells you.
• At the visit, write down the name of a new diagnosis, and any new medicines, treatments, or tests. Also write down any new instructions your healthcare provider gives you.
• Know why a new medicine or treatment is prescribed, and how it will help you. Also know what the side effects are.
• Ask if your condition can be treated in other ways.
• Know why a test or procedure is recommended and what the results could mean.
• Know what to expect if you do not take the medicine or have the test or procedure.
• If you have a follow-up appointment, write down the date, time, and purpose for that visit.
• Know how you can contact your healthcare provider if you have questions.

 

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The patent covers the company’s processes for the use of histidyl-tRNA synthetase Fc fusion proteins in reducing inflammatory responses in the lung.

What is Histidyl tRNA synthetase?


Histidyl-tRNA synthetase (HisRS) is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. This amino acid has uniquely moderate basic properties and is an important group in many catalytic functions of enzymes.

Histidyl-tRNA synthetase - PubMed​

 

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Fc-fusion Proteins​

Fc-fusion proteins are composed of the Fc domain of IgG linked to a peptide or protein of interest. These include, but are not limited too:

• The extracellular domain of a pattern recognition receptors (PRRs)
• Ligands activated upon cell-surface receptor binding
• Signaling molecules (e.g. cytokines)

Fc-fusion proteins can be used for a number of applications including flow cytometry (FC) and protein binding assays. For these in vitroapplications, the Fc domain provides support to the attached protein of interest which retains its native biological activity. Furthermore, the Fc domain can improve the solubility and stability of some binding partners.

https://www.invivogen.com/fc-fusion-proteins

 

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What is the function of Fc fusion proteins?


Fc-fusion proteins are bioengineered polypeptides that join the crystallizable fragment (Fc) domain of an antibody with another biologically active protein domain or peptide to generate a molecule with unique structure–function properties and significant therapeutic potential.16 Oct 2014

Design and Manufacture of therapeutic Fc-fusion ...​

 

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Are fusion proteins antibodies?

Antibody Fusion Proteins are constructs that combine an antibody targeted to a specific antigen, typically a tumor-related antigen, with a protein that is able to amplify the immune response or induce direct damage to the cancer cell.

Antibody Fusion Proteins - Roche​

 

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What is recombinant fusion protein?


A recombinant fusion protein is a protein created through genetic engineering of a fusion gene. ... That DNA sequence will then be expressed by a cell as a single protein. The protein can be engineered to include the full sequence of both original proteins, or only a portion of either.

Fusion protein - Wikipedia​

https://en.wikipedia.org › wiki › Fusion_

 

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Siao cheebye monologue again, who the fuck is interested in your shit topic.

If so free go kitchen take knife and fuck yourself in the cheebye! Serrated bread knife is the best, can scratch your cheebye before slicing it off! Fuck it in and give it a few turns to scratch your tunnel!

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The patent covers the company’s processes for the use of histidyl-tRNA synthetase Fc fusion proteins in reducing inflammatory responses in the lung.

So tRNA is for disease treatment