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SINGAPORE: Scientists from Singapore and Germany have discovered that mutations in a certain gene cause premature ageing in a condition called "wrinkly skin syndrome".
Their findings, published on Tuesday in "Nature Genetics", give insight on how the PYCR1 gene on chromosome 17 could possibly reverse the process of ageing.
A*STAR said Dr Bruno Reversade from its Institute of Medical Biology analysed rare DNA samples from patients all over the world who had signs of ageing at a young age.
They found that the PYCR1 gene was defective in these patients and they had specific mutations normally seen in elderly patients, causing loose skin, bone density loss and cataract.
The research project, which involved 15 hospitals and research centres in 13 countries, found that developing therapies that could increase the activity of PYCR1 might be able to reverse ageing in these affected people or slow it down in normal people.
- CNA/
SINGAPORE: Scientists from Singapore and Germany have discovered that mutations in a certain gene cause premature ageing in a condition called "wrinkly skin syndrome".
Their findings, published on Tuesday in "Nature Genetics", give insight on how the PYCR1 gene on chromosome 17 could possibly reverse the process of ageing.
A*STAR said Dr Bruno Reversade from its Institute of Medical Biology analysed rare DNA samples from patients all over the world who had signs of ageing at a young age.
They found that the PYCR1 gene was defective in these patients and they had specific mutations normally seen in elderly patients, causing loose skin, bone density loss and cataract.
The research project, which involved 15 hospitals and research centres in 13 countries, found that developing therapies that could increase the activity of PYCR1 might be able to reverse ageing in these affected people or slow it down in normal people.
- CNA/
