rare genetic diseases are sextremely difficult to diagnose and pinpoint. for sexample, alström, kennedy, and wolman diseases. the rarest is ribose-5-phosphate isomerase deficiency. how to diagnose and prescribe treatments when there are sextremely few cases? gp's won't be able to figure out and need to refer to specialists. even specialists in sg have a hard time figuring out the underlying and root causes if there is hardly any precedent on record in sg clinics and hospitals. will need to crowdsource with the international medical community. some medical lightbulbs are lit with some of the best doctors in the world cumming together for deep dives in very focused conferences. and these docs have the blessings and funding of their hospitals and labs to allow them to do "breakthrough" research on sample patients. currently, ucsf and stanford hospitals in sillycon valley are competing head to head to attract patients with some of the rarest genetic diseases and disorders.